Intragastric Duodenal Lipids in the Absence of a Pyloric Sphincter: Quantitation, Physical State, and Injurious Potential in the Fasting and Postprandial States

Duane, William; Wiegand, Dorothy M.; Gilberstadt, Mark L.

doi:10.1016/s0016-5085(19)30505-0

Cited by 21 publications

(2 citation statements)

References 21 publications

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“…Postprandial Ten healthy volunteers (aged [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] years) were studied in the supine position. Six of these subjects were also examined in the upright position.…”

Section: Subjects Studied a Healthy Volunteersmentioning

confidence: 99%

Novel approach to quantify duodenogastric reflux in healthy volunteers and in patients with type I gastric ulcer.

Müller-Lissner¹,

Fimmel²,

Sonnenberg³

et al. 1983

Gut

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SUMMARY A new method is described which allows simultaneous measurement of gastric emptying and duodenogastric reflux and avoids transpyloric intubation. After intragastric instillation of a liquid lipid meal in six healthy volunteers the fractional gastric emptying rate was 2.9±0.3 in the upright and 2.5±0 6 SEM x1T2/min in the supine position, respectively (p>0.5). The duodenogastric reflux rate (expressed as fraction of the intraduodenal amount of duodenal marker) was 0.30 (range 0.03-081) and 0.22 (0.01-0.55) x102/min, respectively (p>0.2). Atropine (40 ,g/kg) decreased the supine gastric emptying rate to 1.1 ±02 (p<005) and increased the supine duodenogastric reflux rate to 2.74 (0.04-9.80) x 102/min (p<005). Fasting duodenogastric reflux rate was similar in the supine and upright position, 0.49 (0.04-0.89) and 0.42 (0.06-0.97) x 102/min, respectively (p>0.5). Fractional gastric emptying rate was similar in 10 volunteers and 17 patients with type I gastric ulcer (21±04 vs 1.7±0.2 SEM x 10-2/min, p>0O2). Their duodenogastric reflux rates were also similar, 0-65 (0.01-5.24) vs 1.10 (0.01-10.83)x102/min (p>05). We conclude therefore that (1) gastric emptying and both fasting and postprandial duodenogastric reflux are independent of the posture; (2) fasting and postprandial reflux are of similar magnitude; (3) atropine shows gastric emptying and increases duodenogastric reflux; and (4)

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Section: Subjects Studied a Healthy Volunteersmentioning

confidence: 99%

Novel approach to quantify duodenogastric reflux in healthy volunteers and in patients with type I gastric ulcer.

Müller-Lissner¹,

Fimmel²,

Sonnenberg³

et al. 1983

Gut

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“…Наиболее часто встречающийся компонент рефлюкса -желчь, а именно соли желчных кислот, лизолецитин, лецитин, обладающие канцерогенным потенциалом. При ДГР происходит повреждение слизистой оболочки желудка за счет влияния желчных кислот, лизолецитина, жирных кислот и лецитина [31]. Доказано, что у послеоперационных больных тяжесть гастрита коррелировала с концентрацией желчных кислот, а при изучении состава секрета чаще всего встречалась литохолевая кислота.…”

Section: компоненты дуоденогастрального рефлюксаunclassified

Duodenogastral Reflux and Cholelithiasis: Pathogenetic, Clinical and Morphological Relationships

Насыров¹,

Фоминых²,

Кизимова³

et al. 2023

University Therapeutic Journal

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В этой статье подробно обсуждается понятие о дуоденогастральном рефлюксе, эпидемиологические данные и патогенетические аспекты подобного состояния, включая роль изменений нейрогуморальной регуляции, молекул клеточной адгезии, а также влияние Helicobacter pylori. Приведена информация о компонентах дуоденального рефлюксата, а также особенности их влияния на слизистую оболочку желудка. Кроме того, в статье описываются алгоритмы диагностики химического гастрита, особенности гистопатологических изменений при химическом гастрите, применение расчетных индексов при гистологическом исследовании и возможные подходы к терапии. This article discusses in detail the concept of duodenogastric reflux, epidemiological data and pathogenetic aspects of this condition, including the role of changes in neurohumoral regulation, cell adhesion molecules, and the influence of Helicobacter pylori. The data on the components of duodenal refluxate, as well as their features of their effect on the gastric mucosa are presented. In addition, the article describes the algorithms for diagnosing chemical gastritis, the features of histopathological changes in chemical gastritis, the use of calculated indices in histological examination, and possible approaches to therapy.

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Nutritional Problems Following Gastric and Small-Bowel Surgery

Floch

1981

Nutrition and Diet Therapy in Gastrointestinal Disease

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Intragastric Duodenal Lipids in the Absence of a Pyloric Sphincter: Quantitation, Physical State, and Injurious Potential in the Fasting and Postprandial States

Cited by 21 publications

References 21 publications

Novel approach to quantify duodenogastric reflux in healthy volunteers and in patients with type I gastric ulcer.

Novel approach to quantify duodenogastric reflux in healthy volunteers and in patients with type I gastric ulcer.

Duodenogastral Reflux and Cholelithiasis: Pathogenetic, Clinical and Morphological Relationships

Nutritional Problems Following Gastric and Small-Bowel Surgery

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