Intraductal papillary mucinous neoplasm of the pancreas: Associated cancers, family history, genetic predisposition?

Observational Study of the Incidence of Pancreatic and Extrapancreatic Malignancies During Surveillance of Patients With Branch-duct Intraductal Papillary Mucinous Neoplasm

“…However, this concept relies on case-control studies assessing the prevalence of additional cancers that occurred before or that were concurrent with the diagnosis of IPMN. [12][13][14][15][16][17][18][27][28][29] The previously referenced study by Kawakubo et al found that the overall EPM incidence and the incidence of each of the malignancies was not greater than expected. 19 Our analysis of the incidence of EPMs was limited to 456 patients who were free of them at the time of IPMN diagnosis.…”

Estimation of the prevalence of asymptomatic pancreatic cysts in the population of San Marino

“…It is thought that at least some types of pancreatic cysts are associated with other extra-pancreatic diseases, such as in systemic syndromes (e.g., von Hippel-Lindau disease [24] and Peutz-Jeghers syndrome [25]) or because of a possible, currently not completely understood, common genetic predisposition [26]. The association between IPMNs and extrapancreatic malignancies has recently been investigated in the literature [26e29].…”

Intraductal neoplasms of the pancreas: an update

“…The etiology of IPMNs is not so clear, however, a previous history of diabetes, especially with insulin use, smoking, and a family history of pancreatic ductal adenocarcinoma are regarded as risk factors (10,19). Interestingly, the rate of extrapancreatic malignant tumors (colonic, gastric, bile duct, breast and prostate carcinoma) is reported to be higher in patients with IPMN than in those with pancreatic ductal adenocarcinoma (PDAC) (11,12,(20)(21)(22)(23)(24).…”