Estimation of the prevalence of asymptomatic pancreatic cysts in the population of San Marino

Zanini, Nicola; Giordano, Marco; Smerieri, Elia; d'Abruzzo, Giulio Cipolla; Guidi, Marilyn; Pazzaglini, Giorgio; Luca, Fiorella De; Chiaruzzi, Giorgia; Vitullo, Giovanni; Piva, Paolo; Lombardi, Raffaele; Jovine, Elio; Gatti, Marino; Landolfo, Giovanni

doi:10.1016/j.pan.2015.05.461

Cited by 43 publications

(27 citation statements)

References 30 publications

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“…Thus, these studies may not clearly reflect the true prevalence of incidental pancreatic cysts. The prevalence identified using MRI is higher than that using CT (2.6-5.4% for CT [ 20 , 21 ] vs. 2.4-19.6% for MRI [ 8 , 9 , 22 ]).…”

Section: Discussionmentioning

confidence: 96%

Prevalence of incidental pancreatic cyst on upper endoscopic ultrasound

Martínez

Aparicio

2017

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Background:This study aimed to determine the prevalence of incidental pancreatic cysts in patients undergoing upper endoscopic ultrasound without a known pancreatic abnormality.Methods:This prospective study was conducted in two hospitals in Spain and enrolled consecutive patients referred for upper endoscopic ultrasound for a condition unrelated to the pancreas. Patients with a previous pancreatic anomaly, history of acute or chronic pancreatitis, evidence of acute pancreatitis, previous upper gastrointestinal surgery, or chronic abdominal pain suggestive of pancreatic origin were excluded. Univariate logistic regression was performed to evaluate individual covariates and the incidental pancreatic cyst risk.Results:A total of 298 patients were included, of whom 64 had pancreatic cysts (21.5%; 16.9-26.6%). The mean size of the cysts was 6.3±3.7 (range 3-25) mm. Six cysts (2%) were >10 mm and 16 (5.4%) were compatible with branch duct intraductal papillary mucinous neoplasm. The pancreatic cyst prevalence was similar in the two hospitals and increased significantly with age.Conclusion:The prevalence of incidental pancreatic cysts during endoscopic ultrasound was very high in our study population.

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Section: Discussionmentioning

confidence: 96%

Prevalence of incidental pancreatic cyst on upper endoscopic ultrasound

Martínez

Aparicio

2017

aog

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“…ith widespread use of cross-sectional imaging and ever-increasing advances in both CT and MRI techniques, the incidental detection of pancreatic cystic neoplasms (PCNs) has increased, with a reported prevalence of 2.2% for upper abdominal CT examinations and 19.6% for MRI examinations (1)(2)(3)(4). Since a small percentage of PCNs progress to invasive cancers, the identification of PCNs is often a source of anxiety for patients and leads to challenging management decisions for involved physicians.…”

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confidence: 99%

Follow-up of Incidentally Detected Pancreatic Cystic Neoplasms: Do Baseline MRI and CT Features Predict Cyst Growth?

Pandey

Luo

et al. 2019

Radiology

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Background: Incidental detection of pancreatic cystic neoplasm (PCN) has increased. Since a small percentage of PCNs possess malignant potential, management is challenging. The recently revised American College of Radiology (ACR) recommendations define PCN measurement and growth for different categories based on baseline cyst size. However, no data are available regarding PCN growth rate under the ACR-defined size categories. Purpose: To assess growth of incidentally detected PCNs on long-term imaging follow-up using revised ACR recommendations and to evaluate the association between baseline imaging features and growth. Materials and Methods: This retrospective study included PCNs with baseline imaging performed between January 2002 and May 2017, with two or more cross-sectional imaging studies performed at least 12 months apart. PCN assessment was based on ACR 2017 recommendations. Cyst features, including location, septations, and mural nodules and multiplicity, were noted. Time to cyst progression (growth by ACR criteria) was examined by using baseline PCN size, among other factors. Results: A total of 646 cysts in 390 patients were followed up for a median of 50 months (range, 12-186 months). A total of 184 (28.5%) cysts increased in size, 52 (8.1%) decreased in size, and 410 (63.4%) remained stable. For groups in which baseline PCN size was smaller than 5 mm, 5-14 mm, 15-25 mm, and larger than 25 mm, growth was noted in seven (13.2%), 106 (28.9%), 49 (32.2%), and 22 (29.7%) cysts, respectively. ACR baseline size categories (subhazard ratio: 2.8 [5-14-mm PCN group], 3.4 [15-25-mm PCN group], and 2.7 [.25 mm group], as compared with the ,5 mm PCN group; P , .05 for each) demonstrated association with growth. Presence of mural nodules, septations, or lesion multiplicity failed to demonstrate association with growth. Among PCNs smaller than 5 mm at baseline, 100% of PCNs at 3-year follow-up and 94.2% of PCNs at 5-year follow-up were likely to remain stable. Conclusion: American College of Radiology baseline size category of 15-25-mm pancreatic cystic neoplasms (PCNs) demonstrated the highest (3.1 times) likelihood of growth, as compared with the category of PCNs smaller than 5 mm. PCNs smaller than 5 mm at baseline did not demonstrate growth at 3-year imaging follow-up.

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“…A number of population studies have investigated the rate of PCLs both in asymptomatic subjects and in liver transplanted patients. The former 3 , 4, 22, 23 are generally represented by retrospective database studies, showing a high heterogeneity in the prevalence of PCLs due to different radiological examinations and study design. In those studies, the prevalence of PCLs ranged from 4.2% to 44.7%.…”

Section: Discussionmentioning

confidence: 99%