Intraductal Papillary Cholangiocarcinoma Associated With von Meyenberg Complexes: A Case Report

Neto, Antonio Galvao; Dainiak, Chris; Qin, Lihui; Salem, Ronald R.; Jain, Dhanpat

doi:10.1007/s10620-007-9777-5

Cited by 16 publications

(2 citation statements)

References 11 publications

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“…These lesions are fairly common with prevalence of 5.6% in adults and 0.9% of children in one autopsy series, and are especially prevalent in patients with adult polycystic kidney disease or congenital hepatic fibrosis [40] . VMCs are generally considered benign, but several case reports suggest that these lesions are capable of transformation to cholangiocarcinoma, showing benign, hyperplastic and dysplastic epithelium with adjacent progression to invasive carcinoma, particularly in patients with multiple VMCs [8,38,39,[41][42][43] . This phenomenon has been corroborated with molecular evidence of mutations shared between cholangiocarcinoma and VMCs [44] .…”

Section: A B C Dmentioning

confidence: 99%

Clinical and biological significance of precursor lesions of intrahepatic cholangiocarcinoma

Ettel¹

2015

WJH

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Cholangiocarcinoma (CC) is primarily a malignant tumor of older adults most prevalent in Southeast Asia, where liver fluke infestation is high. However the etiology in western countries is unknown. Although the incidence of extrahepatic cholangiocarcinoma has remained constant, incidence of intrahepatic CC (ICC) which differs in morphology, pathogenesis, risk factors, treatment and prognosis is increasing. While this increase is associated with hepatitis C virus infection, chronic nonalcoholic liver disease, obesity, and smoking, the pathogenesis of ICC and molecular alterations underlying the carcinogenesis are not completely elucidated. Benign biliary lesions such as biliary intraepithelial neoplasia, intraductal papillary neoplasm of the bile duct, von Meyenburg complex or bile duct hamartoma, and bile duct adenoma have been associated with ICC. For each of these entities, evidence suggests or supports a role as premalignant lesions. This article summarized the important biological significance of the precursor lesions of ICC and the molecular mechanisms that may be involved in intrahepatic cholangiocarcinogenesis.

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Section: A B C Dmentioning

confidence: 99%

Clinical and biological significance of precursor lesions of intrahepatic cholangiocarcinoma

Ettel¹

2015

WJH

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“…[59][60][61] Zen et al 62 proposed the diagnostic term intraductal papillary neoplasm of bile duct (IPNB), which encompasses most histopathologic aspects of the intraductal neoplasm of the bile duct (Figure 2, A). Intraductal papillary neoplasm of bile duct shares similar features with pancreatic IPMN in terms of intraductal papillary growth pattern and 4 cell lineage types; however, it differs from pancreatic IPMN with lessfrequent mucin production and more-frequent invasive carcinoma.…”

Section: Biliary Intraductal Papillary Neoplasm Versusmentioning

confidence: 99%

Tumoral Versus Flat Intraepithelial Neoplasia of Pancreatobiliary Tract, Gallbladder, and Ampulla of Vater

Jang

Ahn

2016

Archives of Pathology &Amp; Laboratory Medicine

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Context.-The identification of a precursor lesion is important to understanding the histopathologic and genetic alterations in carcinogenesis. There are a plethora of terminologies that describe precursor lesions of the pancreatobiliary tract, ampulla of Vater, and gallbladder. The current terminologies for precursor lesions may make it difficult to understand the tumor biology. Here, we propose the concept of tumoral and flat intraepithelial neoplasia to improve our understanding of precursor lesions of many epithelial organs, including the pancreatobiliary tract, ampulla of Vater, and gallbladder.Objective.-To understand the dichotomous pattern of tumoral and flat intraepithelial neoplasia in carcinogenesis of pancreatobiliary tract, ampulla of Vater, and gallbladder.Data Sources.-Review of relevant literatures indexed in PubMed.Conclusions.-Tumoral intraepithelial neoplasia presents as an intraluminal or intraductal, mass-forming, polypoid lesion or a macroscopic, visible, cystic lesion without intracystic papillae. Microscopically, tumoral intraepithelial neoplasia shows various proportions of papillary and tubular architecture, often with a mixed pattern, such as papillary, tubular, and papillary-tubular. The malignant potential depends on the degree of dysplasia and the cell phenotype of the epithelium. Flat intraepithelial neoplasia presents as a flat or superficial, spreading, mucosal lesion that is frequently accompanied by an invasive carcinoma. Tumoral and flat intraepithelial neoplasias are not homogeneous entities and may exhibit histopathologic spectrum changes and different genetic profiles. Although intraepithelial neoplasia showed a dichotomous pattern in the tumoral versus flat types, they can coexist. Tumoral and flat intraepithelial neoplasia can be interpreted as part of a spectrum of changes in the carcinogenesis pathway of each organ. A denoma is the prototype precursor lesion in carcinogenesis. The adenoma-carcinoma sequence is one of the well-characterized models of the carcinogenesis pathway. Through the adenoma-carcinoma sequence, many histopathologic and genetic alterations have been characterized in colorectal carcinogenesis.1,2 Another prototype precursor lesion is uterine cervix dysplasia, which also progresses to invasive squamous cell carcinoma of the uterine cervix through multistep carcinogenesis. Both colon adenoma and uterine cervix dysplasia correspond to intraepithelial neoplasia (IN), which can lead to invasive carcinoma. Most colorectal adenomas present as a polypoid lesion, whereas uterine cervix dysplasia presents as a nonpolypoid, flat, mucosal lesion. We think colon adenoma and uterine cervix dysplasia represent a mass-forming tumoral IN and a nonmass-forming, flat IN, respectively. In general, tumoral IN corresponds to a macroscopic or mass-forming lesion, and flat IN presents as invisible or microscopic lesions. Flat adenomas have been reported in the colorectum, which is much closer to a flat IN, and papillary squamous cell carcinoma of the uterine cervix, which is...

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Pathology of Fibrocystic Diseases of the Liver

Truong

Yeh

2010

Fibrocystic Diseases of the Liver

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Intraductal Papillary Cholangiocarcinoma Associated With von Meyenberg Complexes: A Case Report

Cited by 16 publications

References 11 publications

Clinical and biological significance of precursor lesions of intrahepatic cholangiocarcinoma

Clinical and biological significance of precursor lesions of intrahepatic cholangiocarcinoma

Tumoral Versus Flat Intraepithelial Neoplasia of Pancreatobiliary Tract, Gallbladder, and Ampulla of Vater

Pathology of Fibrocystic Diseases of the Liver

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