Simvastatin and CF680 dye encapsulated by stable nanodroplets has been developed for a drug delivery carrier. Simvastatin has previously been demonstrated as a potential degenerative disc disease (DDD) treatment drug. Multiple exposures of the nanodroplet to high-intensity focused ultrasound (HIFU) induced release of simvastatin. Each ultrasound exposure yielded a consistent concentration of the drug and dye released. B-mode ultrasound image analysis data and cavitation data clearly indicated the release mechanism is phase-transition of the liquid nanodroplets to gas bubbles. The nanodroplets were stably stored in ex vivo rabbit spine discs at least for 14 days and the contents responded to ultrasound exposure on demand. Lastly, nucleus pulpous cells harvested from rabbit spine discs and exposed to media with nanodroplets showed a decrease in cell viability (85%) relative to the cells only (96.7%) at 24 hr, but no difference at 48 hr. Thus, the system may be a potential DDD treatment.