Multiple-Exposure Drug Release from Stable Nanodroplets by High-Intensity Focused Ultrasound for a Potential Degenerative Disc Disease Treatment

Nguyen, Khoi D.; Pan, Hsuan-Yeh; Haworth, Kevin J.; Mahoney, Eric; Mercado-Shekhar, Karla P.; Lin, Chien‐Chi; Zhang, Zhe; Park, Yoonjee C.

doi:10.1016/j.ultrasmedbio.2018.09.014

Cited by 9 publications

(8 citation statements)

References 31 publications

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“…Detailed characterization of the nanodroplets is described in our previous publications. , Briefly, the average size of the nanodroplets measured by optical images and by dynamic light scattering was ∼300–500 nm in diameter. To prove a double-emulsion structure of W1/O/W2 visually, we dissolved Rhodamine B dye in W1 phase with a drug.…”

Section: Resultsmentioning

confidence: 99%

Phase-Transition Temperature of Gold-Nanorod-Coated Nanodroplets to Microbubbles by Pulsed Laser

et al. 2019

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Previously, gold-nanorod-coated perfluorocarbon nanodroplets have been developed as light-activated on-demand drug delivery carriers. When gold nanorods on the perfluorocarbon nanodroplets resonate with a laser wavelength, plasmonic heat is generated and vaporizes the nanodroplets to gas bubbles. Optimal laser parameters such as pulse duration, pulse repetition frequency, and average power are critical to effectively trigger the phase transition of nanodroplets and allow for drug release. This study focused on determining the temperature of a goldnanorod-coated perfluorocarbon nanodroplet during phase transition to a gas bubble using a femtosecond laser. Two integrated experimental and theoretical methods were explored. First, the theoretical temperature was determined by the Arrhenius equation and the time it took for the phase transition to occur, assuming the phasetransition process followed a first-order kinetic model. The activation energy and Arrhenius constant of the phase-transition process were obtained via light transmittance through a nanodroplet suspension at different temperatures. The time required for phase transition by a femtosecond laser was measured using an optical microscope. The second approach used a classical heat diffusion model. When the pulse peak energy was considered in the model, the temperature predicted matched the experimental observation of phasetransition temperature threshold, while the total energy value failed to predict the temperature threshold. The results suggest that the phase-transition mechanism is triggered by the vaporization of the nanodroplets via photothermal heating, which is influenced by the peak energy of the laser. It also indicates that optimal laser parameters can be determined by a simple calculation using the classical heat diffusion model and peak energy to control phase transition.

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Section: Resultsmentioning

confidence: 99%

Phase-Transition Temperature of Gold-Nanorod-Coated Nanodroplets to Microbubbles by Pulsed Laser

et al. 2019

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“…(iv) Nanodroplets. A stable nanodroplet encapsulating simvastatin was developed that could release the drug upon exposure to high intensity, focused ultrasound [ 207 ]. Nanodroplets are widely used to load 10-hydroxycamptotheci, a lipophilic anticancer drug [ 208 ].…”

Section: Stimuli-responsive Polymeric Nanocarriers For Drug and Gmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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“…Micro/nanobubble-assisted ultrasound has been demonstrated in a number of new therapeutic areas, such as combination with insulin-like growth factor-1 to generate a better therapeutic response to noise-induced hearing loss [129] or association with transportation of corresponding genes or transposase to the liver of hemophilia B mice to enhance the expression level of factor IX in the liver, so as to achieve the purpose of adjuvant treatment of hemophilia [130]. US-induced delivery technology associated with superparamagnetic iron oxide (SPIO) nanoparticle-loaded gastro-retentive tablets to generate bubbles was also explored to enhance the gastric absorption of drugs and enable imaging Encapsulating statins and CF680 dyes with nano-sized droplets was explored to treat degenerative disc disease [132]. Furthermore, in dental diseases, ultrasound-induced cavitation effects have been shown to effectively enhance the penetration of submicron bubbles into dentinal tubules [133].…”

Section: Other Advanced Therapeutic Applicationsmentioning

confidence: 99%

“…Encapsulating statins and CF680 dyes with nano-sized droplets was explored to treat degenerative disc disease [ 132 ]. Furthermore, in dental diseases, ultrasound-induced cavitation effects have been shown to effectively enhance the penetration of submicron bubbles into dentinal tubules [ 133 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Mechanistic Insights and Therapeutic Delivery through Micro/Nanobubble-Assisted Ultrasound

Zhao

Deng

et al. 2022

Pharmaceutics

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Ultrasound with low frequency (20–100 kHz) assisted drug delivery has been widely investigated as a non-invasive method to enhance the permeability and retention effect of drugs. The functional micro/nanobubble loaded with drugs could provide an unprecedented opportunity for targeted delivery. Then, ultrasound with higher intensity would locally burst bubbles and release agents, thus avoiding side effects associated with systemic administration. Furthermore, ultrasound-mediated destruction of micro/nanobubbles can effectively increase the permeability of vascular membranes and cell membranes, thereby not only increasing the distribution concentration of drugs in the interstitial space of target tissues but also promoting the penetration of drugs through cell membranes into the cytoplasm. These advancements have transformed ultrasound from a purely diagnostic utility into a promising theragnostic tool. In this review, we first discuss the structure and generation of micro/nanobubbles. Second, ultrasound parameters and mechanisms of therapeutic delivery are discussed. Third, potential biomedical applications of micro/nanobubble-assisted ultrasound are summarized. Finally, we discuss the challenges and future directions of ultrasound combined with micro/nanobubbles.

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Multiple-Exposure Drug Release from Stable Nanodroplets by High-Intensity Focused Ultrasound for a Potential Degenerative Disc Disease Treatment

Cited by 9 publications

References 31 publications

Phase-Transition Temperature of Gold-Nanorod-Coated Nanodroplets to Microbubbles by Pulsed Laser

Phase-Transition Temperature of Gold-Nanorod-Coated Nanodroplets to Microbubbles by Pulsed Laser

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Mechanistic Insights and Therapeutic Delivery through Micro/Nanobubble-Assisted Ultrasound

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