Intractable Bimaxillary Osteomyelitis in Osteopetrosis: Review of the Literature and Current Therapy

Öḡütcen-Toller, Melahat; Tek, Mustafa; Şener, İsmail; Bereket, Cihan; İnal, Samet; Özden, Bora

doi:10.1016/j.joms.2005.07.022

Cited by 25 publications

(12 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The dental changes reported to be associated with osteopetrosis include disturbance of tooth eruption, hypodontia, malformed teeth, multiple caries, enamel dysplasia, abnormal pulp chambers, and hypercementosis [12, 13]. The main complication in patients with autosomal dominant osteopetrosis type II is osteomyelitis, particularly affecting the mandible in association with dental caries and abscess [12].…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 40% of those affected are asymptomatic, and marrow failure is rare, and most of patients are diagnosed only when osteomyelitis occurs in the mandible. Other symptoms include bone pain, recurrent fractures, back pain, and degenerative arthritis [13]. Bollerslev and Andersen Jr. described two subtypes of benign autosomal dominant osteopetrosis (ADO) on the basis of radiological and clinical differences; these include ADO type I and ADO type II [8].…”

Section: Introductionmentioning

confidence: 99%

“…Radiographs reveal sclerosis of the skull, which mainly results in increased thickness of the cranial vault; however, the spine does not show much sclerosis. Cranial nerve compression is common in type I [13]. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and Radiological Findings of Autosomal Dominant Osteopetrosis Type II: A Case Report

Kant

Sharda

Bhowate³

2013

Case Reports in Dentistry

View full text Add to dashboard Cite

Osteopetrosis is a rare inherited genetic disease characterized by sclerosis of the skeleton caused by the absence or malfunction of osteoclasts. Three distinct forms of the disease have been recognized, autosomal dominant osteopetrosis being the most common. Autosomal dominant osteopetrosis exhibits a heterogeneous trait with milder symptoms, often at later childhood or adulthood. The aim of this case report is to present the clinical and radiographic features of a 35-year-old female patient with autosomal dominant osteopetrosis type II who exhibited features of chronic generalised periodontitis, and the radiographs revealed generalised osteosclerosis and hallmark radiographic features of ADO type II, that is, “bone-within-bone appearance” and “Erlenmeyer-flask deformity.”

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical and Radiological Findings of Autosomal Dominant Osteopetrosis Type II: A Case Report

Kant

Sharda

Bhowate³

2013

Case Reports in Dentistry

View full text Add to dashboard Cite

show abstract

“…In full-blown cases, there is necrosis of bone and deposition of calcium. Paget 's disease of bone and florid cemento-osseous dysplasia (FCOD) result in decreased vascularity of the affected bone, predisposing to the development of osteomyelitis [5, 6]. Cranial bones are infrequently involved.…”

Section: Discussionmentioning

confidence: 99%

Role of Nasal Endoscopy in Chronic Osteomyelitis of Maxilla and Zygoma: A Case Report

Arunkumar

Naik

Prasad

et al. 2011

Case Reports in Medicine

View full text Add to dashboard Cite

Osteomyelitis of the jaws was relatively common before the era of antibiotic therapy and preventive and restorative dentistry. Osteomyelitis is an acute or chronic inflammatory process that can involve cortical and trabecular aspects of bone or bone marrow. Cranial bones are infrequently involved, but spreading of inflammation with involvement of surrounding structures represents important risk, such as cerebral abscess, encephalitis, or meningitis. The mandible is more commonly involved than the maxilla. Dentogenic infections cause 38% of mandibular and 25% of maxillary involvement. Involvement of zygoma is very rare. Factors like viral fevers, malnutrition, malaria, anemia,tobacco chewing, immunodeficiency, osteopetrosis, Paget's disease of bone, and florid cemento-osseous dysplasia (FCOD) result in decreased vascularity of the affected bone, predisposing to the development of osteomyelitis. We present a case of osteomyelitis of left maxilla and zygoma with oroantral fistula in an immunocompetent adult male caused by dentogenic infection. The complete resolution of infection was gained with surgical treatment using nasal endoscope and antibiotic therapy. The aims of this paper are to illustrate diagnostic patterns, to report radiographic findings and surgical treatment using nasal endoscope in a case of osteomyelitis of maxilla and zygoma. The prognosis and cosmetic results are discussed.

show abstract

“…1 According to its severity it and can be asymptomatic to fatal 2 and it is often diagnosed by radiographic exams 3 , not being essential a bone biopsy. 4 It is usually subdivided into three types: benign autosomal dominant osteopetrosis; intermediate autosomal recessive osteopetrosis; and malignant autosomal recessive infantile osteopetrosis (MIOP), considered the most serious type. This is associated with a decreased life expectancy, with most children dying in the second decade of life with complications of bone marrow suppression.…”

Section: Introductionmentioning

confidence: 99%

Osteomyelitis of the maxilla in a patient with Malignant Infantile Osteopetrosis

Carvalhosa

Marinho

Castro

et al. 2016

Revista Española de Cirugía Oral y Maxilofacial

View full text Add to dashboard Cite

Available online xxxKeywords: Osteopetrosis Osteoclerosis fragilis Marble bone disease Splenomegaly Osteomyelitis a b s t r a c t Osteopetrosis is characterized by a considerable increase in bone density resulting in defective remodeling, caused by failure in the normal function of osteoclasts, and varies in severity. It is usually subdivided into three types: benign autosomal dominant osteopetrosis; intermediate autosomal recessive osteopetrosis; and malignant autosomal recessive infantile osteopetrosis, considered the most serious type. The authors describe a case of chronic osteomyelitis in the maxilla of a 6-year-old patient with Malignant Infantile Osteopetrosis. The treatment plan included pre-maxilla sequestrectomy and extraction of erupted upper teeth. No surgical procedure was shown to be the best to prevent the progression of oral infection. Taking into account the patient's general condition, if the patient develops severe symptomatic and refractory osteomyelitis surgery should be considered. The patient and his family are aware of the risks and benefits of surgery and its possible complications.

show abstract

Intractable Bimaxillary Osteomyelitis in Osteopetrosis: Review of the Literature and Current Therapy

Cited by 25 publications

References 27 publications

Clinical and Radiological Findings of Autosomal Dominant Osteopetrosis Type II: A Case Report

Clinical and Radiological Findings of Autosomal Dominant Osteopetrosis Type II: A Case Report

Role of Nasal Endoscopy in Chronic Osteomyelitis of Maxilla and Zygoma: A Case Report

Osteomyelitis of the maxilla in a patient with Malignant Infantile Osteopetrosis

Contact Info

Product

Resources

About