Intracranial Venous Thrombosis During the First Trimester of Pregnancy

Superior Sagittal Sinus Thrombosis

“…Thrombophlebitis was diag¬ nosed. Findings from coagulation studies were platelets, 300,000/cu mm; prothrombin time, 10.7 seconds (100%), thrombin time, 7.9 seconds (control, 8.3); and fibrinogen, 435 mg/100 ml. She was given heparin sodium, 5,000 units subcutaneously every eight hours, with improvement.…”

Intracranial venous thrombosis in the first trimester of pregnancy.

“…In pregnancy, Carroll et al (1966) found that 34% of cases presented with headache, presumed to be due to raised intracranial pressure, while 30% presented with seizures. The prognosis is variable with a mortality rate of between 33% (Fishman et al, 1957) and 56% (Huggenberg and Kesselring, 1958). Treatment is symptomatic; the role of anticoagulants and fibrinolytic therapy remains doubtful in view of the almost constant pathological finding of haemorrhagic infarction, as in our patient.…”

“…Only two were known to be multiparous (Eckerling et al, 1963;Kalbag and Woolf, 1967). Extensive cortical venous thrombosis with haemorrhagic infarction was found in all but two cases (Fishman et al, 1957;Christensen et al, 1969). In three cases there was a complication of pregnancy (Meinel, 1901;Fishman et al, 1957;Kalbag and Woolf, 1967).…”

“…There are only eight necropsy proven cases described in the literature, occurring during the first trimester of pregnancy (Meinel, 1901;Fishman et al, 1957;Hensell, 1961;Eckerling et al, 1963;Kalbag and Woolf, 1967;Christensen et al, 1969). These show an age range of 20 to 42 years.…”

A case of superior longitudinal sinus thrombosis in pregnancy

“…There are few recorded cases of spontaneous thrombosis of the superior sagittal sinus in pregnancy-Bristow, 1888; Biicklers, 1893; Stertz, 1909;Fishman, Cowen and Silberman, 1957. Thickotter (1891) vulsions and loss of consciousness in the first pregnancy recurring in the second pregnancy.…”