Intracranial vascular flow oscillations in Alzheimer’s disease from 4D flow MRI

Rivera‐Rivera, Leonardo A.; Cody, Karly Alex; Rutkowski, David; Cary, Paul; Eisenmenger, Laura; Rowley, Howard A.; Carlsson, Cynthia M.; Johnson, Sterling C.; Johnson, Kevin M.

doi:10.1016/j.nicl.2020.102379

Cited by 14 publications

(12 citation statements)

References 61 publications

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“…These results align with findings of decreased hippocampal LFOs in amnestic MCI 20 and altered LFOs in AD progression. 50 , 51 However, the observed LFOs may reflect a combination of neuronal activity, neurovascular coupling 21 , 22 and fluctuations of extracerebral origin, related to breathing- and cardiac-variability. 52 Importantly, after controlling for confounders (including HR and HRV), group differences in LFOs remained significant and borderline-significant for the parahippocampal gyrus and hippocampus, suggesting that the observed LFO differences ( Figure 3(d) ) partially reflect impaired microvascular function in the hippocampal complex.…”

Section: Discussionmentioning

confidence: 99%

Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults

Vikner

Eklund

Karalija

et al. 2021

J Cereb Blood Flow Metab

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Microvascular damage in the hippocampus is emerging as a central cause of cognitive decline and dementia in aging. This could be a consequence of age-related decreases in vascular elasticity, exposing hippocampal capillaries to excessive cardiac-related pulsatile flow that disrupts the blood-brain barrier and the neurovascular unit. Previous studies have found altered intracranial hemodynamics in cognitive impairment and dementia, as well as negative associations between pulsatility and hippocampal volume. However, evidence linking features of the cerebral arterial flow waveform to hippocampal function is lacking. We used a high-resolution 4D flow MRI approach to estimate global representations of the time-resolved flow waveform in distal cortical arteries and in proximal arteries feeding the brain in healthy older adults. Waveform-based clustering revealed a group of individuals featuring steep systolic onset and high amplitude that had poorer hippocampus-sensitive episodic memory (p = 0.003), lower whole-brain perfusion (p = 0.001), and weaker microvascular low-frequency oscillations in the hippocampus (p = 0.035) and parahippocampal gyrus (p = 0.005), potentially indicating compromised neurovascular unit integrity. Our findings suggest that aberrant hemodynamic forces contribute to cerebral microvascular and hippocampal dysfunction in aging.

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Section: Discussionmentioning

confidence: 99%

Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults

Vikner

Eklund

Karalija

et al. 2021

J Cereb Blood Flow Metab

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“…Whole brain, time‐resolved 4D flow MRI data were acquired using 3.0T systems (SIGNA Premier and MR750, GE Healthcare) and a 3D radially undersampled sequence 32 . Data were acquired with the following imaging parameters: Venc = 80 cm/s, imaging volume = 22 × 22 × 10 cm 3 , TR/TE = 7.4/2.7 ms, scan time ≈7 min, acquired spatial resolution = 0.7 mm isotropic, flip angle = 8°, bandwidth = 250 kHz, number of projections ≈11,000 25,32 . Cardiac triggers were collected for each subject from a photoplethysmogram on a pulse oximeter (GE Healthcare) worn on the subject's finger during the MRI exam.…”

Section: Methodsmentioning

confidence: 99%

Cerebrovascular stiffness and flow dynamics in the presence of amyloid and tau biomarkers

Rivera‐Rivera

Eisenmenger

Cody

et al. 2021

Alz & Dem Diag Ass & Dis Mo

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Introduction:This work investigated the relationship between cerebrovascular disease (CVD) markers and Alzheimer's disease (AD) biomarkers of amyloid beta deposition, and neurofibrillary tau tangles in subjects spanning the AD clinical spectrum. Methods: A total of 136 subjects participated in this study. Four groups were established based on AD biomarker positivity from positron emission tomography (amyloid [A] and tau [T]) and clinical diagnosis (cognitively normal [CN] and impaired [IM]). CVD markers were derived from structural and quantitative magnetic resonance imaging data.

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“…As 4D Flow MRI can provide comprehensive spatio-temporal velocity vector data closely related to vascular pathophysiology, it can contribute toward public health in terms of predicting and preventing not only vascular diseases but also many other diseases in the near future. 39,40…”

Section: Future Prospectsmentioning

confidence: 99%

Why 4D Flow MRI? Real Advantages

2022

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This special issue of Magnetic Resonance in Medical Sciences features the most recent reviews on 4D Flow MRI. These reviews deal with the current status of the emerging technique of 4D Flow MRI facilitated in various areas that are difficult to obtain with conventional flowmetry. MR signals inherently contain flow velocity information. In previous decades, in vivo blood flow measurement was traditionally performed by 2D methods, such as Doppler ultrasonography and 2D phase-contrast MRI, which have long been regarded as mature techniques in hemodynamic flowmetry. Although 2D velocimetries have many advantages over 4D Flow MRI in terms of cost and accessibility, and provide excellent temporal and in-plane spatial resolutions, they also have some disadvantages. The emerging technology of 4D Flow MRI can overcome the shortcomings of conventional 2D imaging. In recent years, hemodynamic analysis has witnessed significant progress that is primarily attributable to advances in 4D Flow MRI.

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Intracranial vascular flow oscillations in Alzheimer’s disease from 4D flow MRI

Abstract: Highlights High frame rate 4D flow allows quantitation of low frequency flow changes. Changes to Low frequency oscillations (LFOs) were quantifiable during a breath hold. LFOs were found to be altered in subjects with clinical Alzheimer’s disease.

Cited by 14 publications

References 61 publications

Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults

Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults

Cerebrovascular stiffness and flow dynamics in the presence of amyloid and tau biomarkers

Why 4D Flow MRI? Real Advantages

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