Intracranial metastasis from primary spinal primitive neuroectodermal tumor

Abstract

Primary spinal primitive neuroectodermal tumors (PNET) are rare tumors, with only 94 cases reported till date. Metastasis to brain from a spinal PNET is even rarer. In the present report, we evaluate the pathology and treatment of solitary intracranial metastasis from spinal PNET in a 22-year-old female who presented with headache and left hemiparesis and was diagnosed to have right parietal parasagittal tumor. She has been previously diagnosed to have cervicothoracic primary spinal PNET, and was treated by surgery, radiotherapy, and chemotherapy seven years back. The intracranial tumor has been removed and pathological examination confirmed as PNET. She received radiotherapy and chemotherapy with ifosfamide and etoposide, following surgery for the right parietal PNET. At 20 months follow-up, patient is stable and has no recurrence of the disease. Critical review of reported cases of primary spinal PNET metastsising to brain was done.

Primary spinal peripheral primitive neuroectodermal tumor with acute presentation: A case report and review of literature

“…Still these cases require urgent operative decompression as they present with rapidly progressive neurological deficits followed by adjuvant chemo and radiotherapy is given as suggested by literature by Ghanta RK et al in 2013. 11 Both of our cases underwent gross total excision of the tumor followed by adjuvant radiation therapy.…”

Primary dorsal spine primitive neuroectodermal tumor in an adult patient: Case report and literature review

“…psPNET or extraskeletal Ewing's sarcoma (ES) of the spine is a rare entity. [ 1 2 3 4 ] It generally occurs in children and young adults (<35 years) in the lumbosacral region. [ 1 ] Their incidence in patients >50 years of age is limited to a few case reports [ Table 1 ].…”

“…[ 1 2 ] Annual incidence of these tumors is around 0.2–0.4/100,000. [ 1 3 4 ] It is a highly malignant and invasive tumor with poor prognosis usually occurring in children and young adults. [ 1 2 3 4 ] Primary spinal PNETs (psPNET) are even rarer, limited to only a few case reports, especially in patients above 50 years of age.…”

“…[ 1 3 4 ] It is a highly malignant and invasive tumor with poor prognosis usually occurring in children and young adults. [ 1 2 3 4 ] Primary spinal PNETs (psPNET) are even rarer, limited to only a few case reports, especially in patients above 50 years of age. [ 1 ] We present a case of a 50-year-old female who presented to us with rapidly progressive paraparesis without bladder bowel involvement.…”

Primary spinal primitive neuroectodermal tumor on MR imaging

“…FDG/PET appears to be an effective imaging modality for the evaluation of suspected tumor recurrence. [ 11 13 14 ]…”