Intracranial metastases from carcinoma cervix and review of literature

Kumar, Lalit; Tanwar, Rajendra Kumar; Singh, Stadinder Pal

doi:10.1016/0090-8258(92)90239-f

Cited by 42 publications

(40 citation statements)

References 12 publications

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“…Les mé tastases cé ré brales se font gé né -ralement à partir de carcinomes du col uté rin peu diffé rencié s [7]. Les sous types histologiques sont par ordre de fré quence dé croissant : le carcinome é pidermoïde, l'adé nocarcinome, les tumeurs carcinoïdes et le carcinome adé nosquameux [12,15,19]. Ce n'est pas le cas de notre patiente qui avait un carcinome é pidermoïde bien diffé rencié .…”

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Métastase cérébrale à partir d’un carcinome du col utérin: à propos d’un cas

et al. 2009

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The occurrence of brain metastasis from a cervix carcinoma is extremely rare. It accounts only for 0.5 to 1.2% of the cases in earlier literature. Its prognosis is poor. We report the clinical history of a 45-year-old woman diagnosed with squamous cell carcinoma of the cervix and who developed an isolated right frontal lobe metastasis after one year of treatment of the primary disease. Intracranial hypertension was the predominant clinical symptom. The patient underwent surgical excision of the cerebral metastasis completed by adjuvant radiotherapy. The disease course was marked by the death of the patient six months later.Ré sumé : La survenue d'une mé tastase cé ré brale à partir d'un carcinome du col uté rin est extrê -mement rare et ne repré sente que 0,5 à 1,2 % dans les diffé rentes sé ries rapporté es. Son pronostic reste pauvre. Nous rapportons l'observation clinique d'une jeune patiente de 45 ans, opé ré e pour un carcinome é pidermoïde du col uté rin et qui pré sente une anné e plus tard une mé tastase cé ré brale frontale droite. La symptomatologie clinique é tait dominé e par le syndrome d'hypertension intracrâ -nienne. Notre patiente a bé né ficié d'une ré section chirurgicale complé té e par une radiothé rapie. L'é volution a é té marqué e par le dé cè s de la patiente aprè s une duré e de six mois.

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Section: Discussionunclassified

“…Elles sont gé né ralement uniques et siè gent fré quemment au niveau du lobe frontal [6,15,16]. Cependant, des localisations multiples et sous-tentorielles ont é té é galement rapporté es [4,9].…”

Section: Discussionunclassified

Métastase cérébrale à partir d’un carcinome du col utérin: à propos d’un cas

et al. 2009

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“…Reported survival rates beyond 12 months are rare [17], although study results vary according to the specific treatment regimen employed [2, 4, 13, 19]. For example, studies have reported that surgery and irradiation is more effective than irradiation alone (8.3 months vs. 3.8 months median survival) [12].…”

Section: Discussionmentioning

confidence: 99%

Rapid Manifestation of CNS Metastatic Disease in a Cervical Carcinoma Patient: A Case Report

Brown

Epstein²,

Kim

et al. 2007

Oncology

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Objectives: Brain metastases originating from primary cervical carcinoma are very rare. Despite surgery and adjuvant therapy, patient prognosis is extremely unfavorable. Prior studies have reported that the median time from the primary disease’s diagnosis to development of CNS metastases is approximately 18 months. Case Report: A 60-year-old woman was initially diagnosed and treated for FIGO clinical stage IB2 cervical carcinoma in March 2007. She underwent a radical hysterectomy, bilateral salpingo-oophorectomy and peri-aortic lymphadenectomy. Two weeks later, the patient presented with dysmetria and homonymous hemianopsia, which was related to a large right occipital CNS metastasis. The patient had surgery to resect the brain tumor and then received Gamma Knife stereotactic radiosurgery and chemotherapy. The neurological deficits were resolved and the patient’s disease status has since remained stable, with five months of follow-up. Conclusion: The incidence of brain metastases originating from primary cervical carcinoma is very rare. Furthermore, the occurrence of CNS metastatic disease manifesting itself within a couple weeks following diagnosis of the primary disease is even more unusual. Since the presenting symptoms of CNS metastatic disease are not well characterized and patient prognosis is very poor, oncology physicians should anticipate the presence of this condition in order to provide prompt and comprehensive treatment.

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“…6,9Y12 Metastases from CC to the CNS (CNSm) are more frequently found in patients with small cell neuroendocrine carcinoma of the cervix. 13,14 Before 1992, only 41 cases had been reported, 15 and for 2006, only 80 cases of CC patients with CNSm, including all histological subtypes were reported. 16 …”

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confidence: 99%