Central Nervous System Metastases in Patients With Cervical Carcinoma

Abstract

The present study describes the largest series of patients with CNSm from CC; this rare complication should be suspected in patients with CC who present with headache, ataxia, cranial nerve palsy, visual disturbance, altered mental status, focal weakness, or other neurological symptom, without other plausible explanation.

Pathologically confirmed brain metastases from primary uterine cervical tumors: two cases and a literature review

“…It is worth noting that almost half of the patients (up to 40%) with intracranial metastasis from CC had advanced stage disease [7, 16]. In another report of 27 patients, 21 (77.8%) had stage IIB disease or more advanced stages of disease [29]. Most patients with brain metastasis also developed recurrence at extracranial sites, including in the lungs (39%), bones (16%), and abdomen/pelvis (16%) [7].…”

“…Records from 81 patients with uterine cancer metastasis to the brain in Japan showed a median OS of 7 months (95% CI 4–10) [48]. In another study, the mean survival was 8.2 months after central nervous system metastasis was discovered [29]. It has been suggested that the treatment modality, particularly combined therapies, is significantly related to OS [49].…”

Brain Metastases from Uterine Cervical and Endometrial Cancer

“…The interval between the primary diagnosis and BMs was available for 216 patients [11,[14][15][16]18,[20][21][22][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][43][44][45]47,[50][51][52][53][55][56][57][59][60][61][62]64,65,67,72,73,75,76,80,83], and ranged from −1 week to 386 months (median 24 months). A literature review published in 2012 reported that the median interval between the diagnosis of CC and BMs was 18 months [148].…”

“…The initial symptoms of BMs from CC may be nonspecific, and may include headaches (45.6%), syncope or seizures (14.0%), ataxia (11.8%), nausea/vomiting (11.0%), hemiparesis (10.3%), visual disturbance including diplopia (8.8%), generalized or extremity weakness (8.8%), altered mental status (6.6%), dizziness (5.1%), confusion (5.1%), speech impairment (5.1%), paresthesia, facial twitching, tinnitus, tremor and hemiballismus [11,14,18,20,21,[23][24][25][26]28,29,[31][32][33][34][35][37][38][39][42][43][44][45]47,[50][51][52][55][56][57][58]60,61,[63][64][65]76,80,81]. Intracranial edema resulted in papilledema due to the increased intracranial pressure, which is a common sign of a brain tumor [64,148]. These symptoms and signs are the same as those of other brain-occupying lesions.…”

“…Extracranial [11,14,16,18,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][42][43][44][45][46][47][50][51][52][53][54][55][56][57][58][59][60][61][62]64,65,[72][73][74][75][76]80,81,83]. The proportion of patients without extracran...…”