Intracranial hemorrhage with amphetamine abuse

Delaney, Peyton; Estes, M. D.

doi:10.1212/wnl.30.10.1125

Cited by 129 publications

(38 citation statements)

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“…In the literature, amphetamine and MArelated CVAs are predominantly hemorrhagic strokes. 5,[7][8][9][10][11][12] Paradoxically, hemorrhagic strokes account for less than one fourth of CVAs in the general population. 13 MA-related ICHs have been reported in all cerebral lobes, with the majority involving the frontal lobe, as seen in our case.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Intracerebral Hemorrhage Related to Methamphetamine Abuse

McGee¹,

McGee²,

McGee³

2004

American Journal of Forensic Medicine &Amp; Pathology

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A healthy 31-year-old male abstinent from drug abuse during his recent incarceration developed slurred speech, a severe headache, and left-sided hemiparesis prior to his eventual death 9.5 hours after inhalation of methamphetamine. On postmortem examination, inspection of the brain revealed bilateral subarachnoid hemorrhage, with a prominent intralobar hemorrhage centered within the right frontal cerebral hemisphere. No evidence of vasculitis, infarction, intraventricular hemorrhage, or ruptured aneurysm could be observed. While this is not the first report of a methamphetamine-related stroke, this report describes the autopsy findings of an intracerebral hemorrhage secondary to methamphetamine abuse on autopsy and compares the findings and antemortem history to previously reported methamphetamine cerebral vascular deaths.

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Section: Discussionmentioning

confidence: 99%

Spontaneous Intracerebral Hemorrhage Related to Methamphetamine Abuse

McGee¹,

McGee²,

McGee³

2004

American Journal of Forensic Medicine &Amp; Pathology

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“…In addition, a number of other detrimental physical and mental health consequences can occur, including nutritional deficiencies, sleep deprivation, and rapid tooth decay, known as "meth mouth" (ADA Division of Communications 2005; National Institute on Drug Abuse 2006). A number of cases of MA-related mortality have been reported, not only due to excessive use or overdosing, but also because of hypersensitivity to MA or the drug's prominent hypertensive effects (e.g., Delaney and Estes 1980;Hall et al 1973). In addition, MA abusers have significantly elevated infection rates for diseases such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV) as a result of both injection drug use (i.e., needle sharing) and risky sexual behavior (e.g., unprotected sex), especially among the population of men who have sex with men (Bluthenthal et al 2001;Gonzales et al 2006;Halkitis et al 2001;Shoptaw 2006).…”

Section: Effects Of Chronic Methamphetamine Usementioning

confidence: 99%

Neurocognitive Effects of Methamphetamine: A Critical Review and Meta-analysis

et al. 2007

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This review provides a critical analysis of the central nervous system effects of acute and chronic methamphetamine (MA) use, which is linked to numerous adverse psychosocial, neuropsychiatric, and medical problems. A meta-analysis of the neuropsychological effects of MA abuse/dependence revealed broadly medium effect sizes, showing deficits in episodic memory, executive functions, information processing speed, motor skills, language, and visuoconstructional abilities. The neuropsychological deficits associated with MA abuse/dependence are interpreted with regard to their possible neural mechanisms, most notably MA-associated frontostriatal neurotoxicity. In addition, potential explanatory factors are considered, including demographics (e.g., gender), MA use characteristics (e.g., duration of abstinence), and the influence of common psychiatric (e.g., other substance-related disorders) and neuromedical (e.g., HIV infection) comorbidities. Finally, these findings are discussed with respect to their potential contribution to the clinical management of persons with MA abuse/dependence.

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“…Angiographic evidence of spasm has also been seen acutely following the intracisternal injection of norepinephrine.' 3 Although extracerebral angiitis has been well demonstrated in drug abusers, 4 14 few attempts have been made to correlate cerebral arteriographic changes with histopathology. In 16 amphetamine-related haemorrhages reviewed by Delaney and Estes, 3 10 patients underwent angiography and beading was demonstrated in only 4.…”

mentioning

confidence: 99%

“…3 Although extracerebral angiitis has been well demonstrated in drug abusers, 4 14 few attempts have been made to correlate cerebral arteriographic changes with histopathology. In 16 amphetamine-related haemorrhages reviewed by Delaney and Estes, 3 10 patients underwent angiography and beading was demonstrated in only 4. Of these, pathological study was lacking in 3, and necrotizing cerebral angiitis was demonstrated in the remaining patient."…”

mentioning

confidence: 99%

Intracerebral haemorrhage and angiographic beading following ingestion of catecholaminergics.

Stoessl¹,

Young²,

Feasby³

1985

Stroke

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SUMMARY We report two cases of serious intracerebral haemorrhage occurring in young women following their first use of oral medications containing catecholaminergic agents (phenylpropanolamine in combination with ephedrine or pseudoephedrine). Both women were previously well, and there was no evidence for systemic vasculitis, coagulopathy, aneurysm or arteriovenous malformation. Angiography in both cases, performed approximately forty hours following drug ingestion, revealed the beading pattern typical of that seen in previously reported cases of presumed amphetamine-induced "vasculitis." We believe that this arteriographic abnormality is non-specific and should not be construed as necessarily indicative of arteritis.

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Intracranial hemorrhage with amphetamine abuse

Abstract: Intracranial hemorrhage (ICH) occurred in a drug abuser soon after self-administration of amphetamine. Other reported cases indicate a consistent clinical picture, sometimes fatal or causing permanent neurologic disability.

Cited by 129 publications

References 0 publications

Spontaneous Intracerebral Hemorrhage Related to Methamphetamine Abuse

Spontaneous Intracerebral Hemorrhage Related to Methamphetamine Abuse

Neurocognitive Effects of Methamphetamine: A Critical Review and Meta-analysis

Intracerebral haemorrhage and angiographic beading following ingestion of catecholaminergics.

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