Neurocognitive Effects of Methamphetamine: A Critical Review and Meta-analysis

Scott, J. Cobb; Woods, Steven Paul; Matt, Georg E.; Meyer, Rachel; Heaton, Robert K.; Atkinson, J. Hampton; Grant, Igor

doi:10.1007/s11065-007-9031-0

Cited by 587 publications

(564 citation statements)

References 190 publications

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“…Although a similar trend was observed in the impairment rates for executive functions, this pattern of results suggests that the domain of learning may be more sensitive to both HIV and the combination of HIV and methamphetamine than the domain of executive functions. A previous meta-analysis of human studies found that the domain of learning is the most sensitive to methamphetamine-induced cognitive impairments (Scott et al, 2007). Consistent with these findings, we observed subtle effects in the domain of learning, but not on executive functions.…”

Section: Hiv Disease and Methamphetamine Dependence In Humanssupporting

confidence: 91%

Methamphetamine Exposure Combined with HIV-1 Disease or gp120 Expression: Comparison of Learning and Executive Functions in Humans and Mice

Kesby

Heaton

Young

et al. 2015

Neuropsychopharmacol

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Methamphetamine dependence is a common comorbid condition among people living with HIV, and may exacerbate HIV-associated neurocognitive disorders. Animal models of neuroAIDS suggest that the gp120 protein may also cause cognitive impairment. The present work evaluated the separate and combined effects of HIV/gp120 and methamphetamine on learning and executive functions in both humans and transgenic mice. Human participants were grouped by HIV serostatus (HIV+ or HIV − ) and lifetime methamphetamine dependence (METH+ or METH − ). A neurocognitive test battery included domain-specific assessments of learning and executive functions. Mice (gp120+ and gp120 − ) were exposed to either a methamphetamine binge (METH+) or saline (METH − ), then tested in the attentional-set-shifting task to assess learning and executive functions. In humans, HIV status was associated with significant impairments in learning, but less so for executive functions. The frequency of learning impairments varied between groups, with the greatest impairment observed in the HIV+/METH+ group. In mice, gp120 expression was associated with impairments in learning but not reversal learning (executive component). The greatest proportion of mice that failed to complete the task was observed in the gp120 +/METH+ group, suggesting greater learning impairments. Our cross-species study demonstrated that HIV in humans and gp120 in mice impaired learning, and that a history of methamphetamine exposure increased the susceptibility to HIV-associated neurocognitive deficits in both species. Finally, the similar pattern of results in both species suggest that the gp120 protein may contribute to HIV-associated learning deficits in humans.

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Section: Hiv Disease and Methamphetamine Dependence In Humanssupporting

confidence: 91%

Methamphetamine Exposure Combined with HIV-1 Disease or gp120 Expression: Comparison of Learning and Executive Functions in Humans and Mice

Kesby

Heaton

Young

et al. 2015

Neuropsychopharmacol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Behavioral treatments, such as cognitive behavioral therapy, are the principal therapeutic strategy used for MA dependence, but they have only achieved modest success (Lee and Rawson, 2008). One reason for the limited efficacy of such therapeutic interventions may be the cognitive impairments associated with chronic MA abuse (eg, London et al, 2005;Monterosso et al, 2005;Salo et al, 2005;Scott et al, 2007;Simon et al, 2010). These impairments may interfere with behavioral treatment, leading to poor treatment retention and outcome (Vocci, 2008).…”

Section: Introductionmentioning

confidence: 99%

Effect of Modafinil on Learning and Task-Related Brain Activity in Methamphetamine-Dependent and Healthy Individuals

Ghahremani

Tabibnia

Monterosso

et al. 2011

Neuropsychopharmacol

109

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Methamphetamine (MA)-dependent individuals exhibit deficits in cognition and prefrontal cortical function. Therefore, medications that improve cognition in these subjects may improve the success of therapy for their addiction, especially when cognitive behavioral therapies are used. Modafinil has been shown to improve cognitive performance in neuropsychiatric patients and healthy volunteers. We therefore conducted a randomized, double-blind, placebo-controlled, cross-over study, using functional magnetic resonance imaging, to examine the effects of modafinil on learning and neural activity related to cognitive function in abstinent, MA-dependent, and healthy control participants. Modafinil (200 mg) and placebo were administered orally (one single dose each), in counterbalanced fashion, 2 h before each of two testing sessions. Under placebo conditions, MA-dependent participants showed worse learning performance than control participants. Modafinil boosted learning in MA-dependent participants, bringing them to the same performance level as control subjects; the control group did not show changes in performance with modafinil. After controlling for performance differences, MAdependent participants showed a greater effect of modafinil on brain activation in bilateral insula/ventrolateral prefrontal cortex and anterior cingulate cortices than control participants. The findings suggest that modafinil improves learning in MA-dependent participants, possibly by enhancing neural function in regions important for learning and cognitive control. These results suggest that modafinil may be a suitable pharmacological adjunct for enhancing the efficiency of cognitive-based therapies for MA dependence. Neuropsychopharmacology (2011) 36, 950-959;

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“…Amphetamine use has been associated with impulsive, aggressive, antisocial, and, in cases, homicidal behaviour in some studies (Qu'est-ce que le captagon, la drogue des djihadistes 2015; Alabdalla 2005; Sekine et al 2006;Scott et al 2007;Freese et al 2002), especially when used in higher dosages and with longer use (Anglin et al 2000). A study of 1016 amphetamine users reported high levels of psychiatric symptoms, particularly depression and attempted suicide, but also anxiety and psychotic symptoms (Lineberry & Bostwick 2006).…”

Section: In Memoriam: the Victims Of The Paris Attacks Of November 13mentioning

confidence: 99%

Pharmacoterrorism: the potential role of psychoactive drugs in the Paris and Tunisian attacks

Fond

Howes

2016

Psychopharmacology

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Neurocognitive Effects of Methamphetamine: A Critical Review and Meta-analysis

Cited by 587 publications

References 190 publications

Methamphetamine Exposure Combined with HIV-1 Disease or gp120 Expression: Comparison of Learning and Executive Functions in Humans and Mice

Methamphetamine Exposure Combined with HIV-1 Disease or gp120 Expression: Comparison of Learning and Executive Functions in Humans and Mice

Effect of Modafinil on Learning and Task-Related Brain Activity in Methamphetamine-Dependent and Healthy Individuals

Pharmacoterrorism: the potential role of psychoactive drugs in the Paris and Tunisian attacks

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