Intracranial Fibrosarcoma Arising 5 Years after Chemotherapy Alone for Glioblastoma multiforme in a Child

Abstract

We present a child diagnosed with glioblastoma multiforme during infancy and successfully treated with the ‘eight-in-one’ chemotherapy regimen, who developed an intracranial fibrosarcoma 5 years later. After resection of the fibrosarcoma, she received cranial radiation therapy and high dose chemotherapy with bone marrow transplant. She remains alive and recurrence-free 7 years following the diagnosis of her second intracranial malignancy.

Short Interval Infield Sarcoma Development following Resection of Glioblastoma and Adjuvant Radiotherapy and Temozolomide

“…A 9-month-old with a GBM treated with surgery and chemotherapy, but not radiotherapy, developed an intracranial fibrosarcoma 5 years later [7]. The second, a 43-year-old with an intraparenchymal fibrosarcoma treated with surgery followed by fractionated conformal radiotherapy developed a recurrence 3 months later and was treated with stereotactic radiosurgery.…”

Secondary fibrosarcoma of the brain stem treated with cyclophosphamide and Imatinib

“…Sarcomas of the central nervous system are exceedingly rare tumors, accounting for only 1.5% of the total intracranial tumors [14, 15]. They can be classified in four categories.…”

“…However, none of the older chemotherapy regimens contained pathway-selective drugs. The drugs used had the potential for severe side-effects and impact on the patient quality of life [2, 9, 14]. …”