Short Interval Infield Sarcoma Development following Resection of Glioblastoma and Adjuvant Radiotherapy and Temozolomide

Abstract

Background. The development of 2 unassociated brain cancers in the same patient is a rare occurrence. Secondary cancers are generally thought to develop as an oncogenic consequence of the radiation therapy delivered to treat the primary cancers, always requiring a significant time interval between radiation treatment and secondary cancer development. Case Description. We report the development of an undifferentiated myxoid sarcoma only 13 months following radiation therapy for a glioblastoma. Conclusion. This case represents the shortest time interval reported between radiation therapy and secondary brain cancer development.

Unique Case Report of a Meningeal Sarcoma Arising during Ongoing Treatment for Progressing Intraparenchymal Glioma

“…Reported 5-year survival rates are estimated at less than 30% [34]. Our literature review [2–4, 35, 37–43, 45, 46] confirmed that, whether treated by radiation, surgery, chemotherapy, or a combination, the 10-year survival rate was 17.4% (4/23 patients).…”

“…While there is no standard criteria for defining a sarcoma as radiation-induced, our case does not fit the popular description by Cahan et al [44], which specified that the sarcoma begin more than one year after radiation. One similar case, reported by Alotaibi and Petrecca, of a 47-year-old man treated with whole brain radiation therapy for a glioblastoma, had a latency of 13 months before the induction of the sarcoma [45]. This case was a single tumor that was resected surgically and subsequently treated with radiotherapy followed by doxorubicin chemotherapy and a positive outcome.…”

An Unusual Case of Sarcoma Developing in a Previously Diagnosed Ependymoma-Case Report

“…Amplification of MDM2 has been described in ependymomas and conventional gliosarcomas, in some instances in the sarcomatous component only or with co amplification of CDK4 [3]. Because sarcomatous transformation may be found in astrocytic as well as oligodendroglial and ependymal tumors, it suggests that this phenomenon might be analogous to sarcomatoid change in a variety of carcinomas occurring outside of the central nervous system [9][10][11].…”