Intracranial Fetus In Fetu—a Pediatric Rarity

Surana, Apurva; Aggarwal, Ankita; Krishnan, Venkatram; Malik, Amita; Misra, Ritu

doi:10.1016/j.wneu.2020.03.156

Cited by 4 publications

(6 citation statements)

References 7 publications

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“…In the 19th Century, Meecker first described FIF as a rare phenomenon in which a fetus of deformed twins was parasitized in the abdominal cavity of its healthy partner (1). FIF is relatively rare in clinical practice, with most reports thus far being single case reports (9,(12)(13)(14)16). Most FIF are obstructed in their organ development and thus manifest with anencephaly and/or asthenia.…”

Section: Discussionmentioning

confidence: 99%

“…Cartilage or teeth, single or multiple cysts can be seen on the cut surface, and the cysts may contain sebum or mucus. The majority of FIF are located in the retroperitoneal space of the abdomen; FIFs in other parts are rare ( 9 ). FIF are covered with skin and hair, have a clear source of blood supply similar to the structure of the umbilical cord, and are located in the amniotic sac, which can stop growing due to insufficient blood supply.…”

Section: Discussionmentioning

confidence: 99%

“…FIF often show characteristic human development with presence of organs, tissues, and/or hair. They are mostly found in the retroperitoneum, but can also be found in the abdominal cavity, cranial cavity, sacrum, mediastinum, scrotum, oral cavity, kidneys, and even as cryptorchidism (1,(9)(10)(11). Clinically, it typically manifests as abdominal distension and a painless mass in the abdomen.…”

Section: Introductionmentioning

confidence: 99%

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Rare Fetus-in-Fetu: Experience From a Large Tertiary Pediatric Referral Center

Mao

Lingxi²,

Song³

et al. 2021

Front. Pediatr.

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Objective: Fetus-in-fetu (FIF) is an extremely rare disease, and most prior publications are single case reports. Here, we describe the clinical characteristics, imaging manifestations, and the treatment and related complications of FIF from a large tertiary pediatric referral center.Materials: After institutional review board approval, patients with a diagnosis of FIF between January 2010 and November 2019 were further selected and reexamined. We analyzed the general clinical characteristics, imaging manifestations, treatment, and prognosis of the patients.Results: A total of seven (four male and three female) patients with FIF were included in the study. All patients were diagnosed with FIF during the antenatal ultrasound examination along with an abnormal increase in alpha fetoprotein, and it was confirmed by subsequent pathological examination. The median gestation period when FIF was first diagnosed was 25 (range: 22–32) weeks. Ultrasound, computed tomography, and magnetic resonance imaging were the main pre-operative diagnostic techniques used. All patients underwent FIF resection within 1 month after birth: four patients had open surgery and three had laparoscopic surgeries (one case was converted to open surgery); only one patient developed ascites after surgery. All patients are growing up healthy and without tumor recurrence at the last follow-up. The level of alpha fetoprotein decreased to normal within 1 year (range 3-10 months) after surgery performed.Conclusion: As the size of the FIF increases, it can be found and diagnosed in antenatal ultrasound examination. Surgery is an important curative treatment for FIF and generally results in excellent long-term quality of life.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rare Fetus-in-Fetu: Experience From a Large Tertiary Pediatric Referral Center

Mao

Lingxi²,

Song³

et al. 2021

Front. Pediatr.

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“…Thyroid, parathyroid, pancreas, spleen, kidney, adrenal, testis, ovaries, urinary bladder, tongue, salivary glands, lymph nodes, trachea, and teeth tissues were also reported. Surana et al [ 8 ] showed that most FIF report have spinal column (over 90%) and limbs (over 80%), and all were anencephalic. Most site was retroperitoneal with abdomen, scrotum, cranium, kidneys, adrenals, mediastinum, and lymph nodes being cited.…”

Section: ⧉ Discussionmentioning

confidence: 99%

“…The most common site for FIF is retroperitoneum, but they have in found in cranial cavity [ 7 , 8 ], oral cavity [ 9 ], neck, thorax [ 10 ], liver [ 11 ], spleen, adrenal gland and sacrococcygeal regions [ 12 ]. Normally, most cases are reported in infants, but several cases have been reported in adults.…”

Section: ⧉ Introductionmentioning

confidence: 99%

A rare case of intrathoracic fetus in fetu / mature teratoma – pathological and imagistic aspects

Demetrian

Nemes²,

Macovei³

et al. 2022

Rom J Morphol Embryol

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Fetus in fetu (FIF) is a rare entity, with a difficult preoperative diagnosis, frequently being an intraoperative surprise. In recent literature, theories pertaining to its development either assimilate the tumor with a monochorionic twin that halted its evolution, or with a highly differentiated mature teratoma. We present the case of a 27-year-old patient, with a cystic tumor in the anterior mediastinum, which intraoperatively proved to be a rare case of intrathoracic FIF. The clinical presentation lacked any specific clues that would infer such a diagnosis; imaging was partially useful as it shown the possible existence of bone structures, heterogeneously mixed with fatty inclusions and other types of tissue. Upon surgery, the nature of said tumor was clear, and pathology confirmed the FIF diagnosis, showing different types of epithelia and tissue of several organ-like structures that halted in evolution at an early stage. Concluding our presentation, we can say that the presence of an axial skeleton as well as differentiated tissue types of several organs could confirm our case of FIF.

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A cohort of five cases with asymmetric conjoined twining and literature review

Zhi

Zhao

et al. 2021

Pediatr Surg Int

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Intracranial Fetus In Fetu—a Pediatric Rarity

Cited by 4 publications

References 7 publications

Rare Fetus-in-Fetu: Experience From a Large Tertiary Pediatric Referral Center

Rare Fetus-in-Fetu: Experience From a Large Tertiary Pediatric Referral Center

A rare case of intrathoracic fetus in fetu / mature teratoma – pathological and imagistic aspects

A cohort of five cases with asymmetric conjoined twining and literature review

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