Intracranial extension of inflammatory pseudotumor of the orbit

Kaye, Andrew H.; Hahn, Joseph F.; Craciun, Atanase; Hanson, Maurice; Berlin, A. Jan; Tubbs, Raymond R.

doi:10.3171/jns.1984.60.3.0625

Cited by 66 publications

(33 citation statements)

References 22 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The inflammatory process within the orbital fat may be localized, and this process can simulate a tumor or may be diffuse within the fatty tissue. The involvement of the lacrimal gland and muscle cone is particularly common (4, 6). …”

Section: Discussionmentioning

confidence: 99%

MR Imaging of Orbital Inflammatory Pseudotumors with Extraorbital Extension

et al. 2005

View full text Add to dashboard Cite

ObjectiveTo demonstrate a variety of MR imaging findings of orbital inflammatory pseudotumors with extraorbital extension.Materials and MethodsWe retrospectively reviewed the MR features of five patients, who were diagnosed clinically and radiologically as having an orbital inflammatory pseudotumor with extraorbital extension.ResultsThe types of orbital pseudotumors were a mass in the orbital apex (n = 3), diffuse form (n = 2), and myositis (n = 1). The extraorbital extension of the orbital pseudotumor passed through the superior orbital fissure in all cases, through the inferior orbital fissure in two cases, and through the optic canal in one case. The orbital lesions extended into the following areas: the cavernous sinus (n = 4), the middle cranial fossa (n = 4), Meckel's cave (n = 2), the petrous apex (n = 2), the clivus (n = 2), the pterygopalatine fossa and infratemporal fossa (n = 2), the foramen rotundum (n = 1), the paranasal sinus (n = 1), and the infraorbital foramen (n = 1). On MR imaging, the lesions appeared as an isosignal intensity with gray matter on the T1-weighted images, as a low signal intensity on the T2-weighted images and showed a marked enhancement on the post-gadolinium-diethylene triamine pentaacetic acid (post-Gd-DTPA) T1-sequences. The symptoms of all of the patients improved when they were given high doses of steroids. Three of the five patients experienced a recurrence.ConclusionMR imaging is useful for demonstrating the presence of a variety of extraorbital extensions of orbital inflammatory pseudotumors.

show abstract

Section: Discussionmentioning

confidence: 99%

MR Imaging of Orbital Inflammatory Pseudotumors with Extraorbital Extension

et al. 2005

View full text Add to dashboard Cite

show abstract

“…11 Another factor that distinguishes ISOI from NSOI is the tendency in some patients to develop aggressive disease. [12][13][14][15][16][17] We had 4 patients with extension of the inflammatory mass into the infratemporal fossa, 3 of whom also had involvement of the pterygopalatine fossa. Another patient had intracranial disease, another showed bone thinning, and another had anterior spread onto the cheek.…”

Section: Commentmentioning

confidence: 99%

Idiopathic Sclerosing Orbital Inflammation

Hsuan

Selva²,

McNab³

et al. 2006

Arch Ophthalmol

View full text Add to dashboard Cite

Objective: To perform a multicenter review of the clinical features and treatment of 31 patients with idiopathic sclerosing orbital inflammation. Methods:We included all patients with histologically confirmed idiopathic sclerosing orbital inflammation from 5 regional orbital centers. We reviewed the case notes to determine the clinical presentation, diagnostic features, and response to treatment. The main outcome measures were duration and nature of symptoms, anatomical location of disease, histopathological findings, treatment modalities, treatment efficacy and adverse effects, and final clinical status.Results: We included 13 male and 18 female patients ranging in age from 7 to 83 years. The average duration of symptoms at presentation was 13.4 months. There was a predilection for the lateral and superior quadrants. Thir-teen patients had apical disease, and 4 had extraorbital involvement. Histopathological findings invariably showed sclerosis associated with a sparse mixed cellular infiltrate. Twenty-seven patients were treated with oral prednisolone, response to which was good in 9 patients, partial in 11, and poor in 7. Six patients were treated with a second-line immunosuppressive agent, and 6 received radiotherapy. The response to radiotherapy was generally poor.Conclusions: Idiopathic sclerosing orbital inflammation is a rare condition that can be difficult to diagnose and manage. Early intervention with immunosuppression in the form of corticosteroids combined with secondline agents can result in control and even regression of the disease.

show abstract

“…Typically, there is a temporal sequence of events that demonstrates that the inflammatory process initiates within the orbit and then spills over adjacent structures. Kaye et al 7 and Borruat et al 12 adequately document in their case study that inflammation was originally confined to the orbital contents and extended with time beyond the orbit. In the cases reported by Frohman et al 2 and De Jesús et al, 13 the authors suggested that when more extensive orbital disease was seen compared with the extraorbital inflammation, its origin was probably within the orbit.…”

Section: Discussionmentioning

confidence: 95%

“…4 -7 To date, up to 15 patients with IOI have been reported with intracranial involvement (Table 1). 2,3,[5][6][7][8][9][10][11][12][13] In the vast majority of patients with idiopathic orbital and extraorbital inflammation, the cranial cavity or sinuses are usually involved (Table 1).…”

Section: Discussionmentioning

confidence: 99%