Intracranial adenoid cystic carcinoma: Case report and review of the literature

Alleyne, Cargill H.; Bakay, Roy A.E.; Costigan, Donal; Thomas, Bill; Joseph, Greg J.

doi:10.1016/0090-3019(95)00235-9

Cited by 45 publications

(67 citation statements)

References 29 publications

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“…1,[3][4][5][6] Perineural invasion was found in 52.6% of primary resection specimens with local invasion, perineural extension, and a tendency toward local recurrence and distant metastasis. 1,6) The present case showed similar characteristics. The tumor contained cribriform patterns, although the solid pattern of ACC seems to have the worst prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…The most common route is via contiguous perineural invasion. [1][2][3]6) In addition, three routes have been reported for the intracranial invasion of salivary gland ACCs: the eustachian tube (in the peritubal space), 1,[5][6][7] the mandibular and maxillary nerves, and the internal carotid artery. 3,5) In the present case, the tumor was located in the right Meckel's cave and cavernous sinus with invasion of the foramen rotundum, foramen ovale, and superior orbital fissure.…”

Section: Discussionmentioning

confidence: 99%

“…The tumor contained cribriform patterns, although the solid pattern of ACC seems to have the worst prognosis. [1][2][3]5) The optimum treatment for ACC is radical surgical resection. 1,3,5,7) However, total resection is almost impossible because of the invasive character, 5) and most ACCs (42%) recur within the first 3 years.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][5][6][7] ACCs account for 11% 5) or 25-30% 4) of epithelial neoplasms in the lacrimal gland. The incidence of intracranial invasion varies from 4% [1][2][3]5,6) to 22%. 7) Most reported intracranial ACCs are located at the base of the skull.…”

Section: Introductionmentioning

confidence: 99%

“…1,6) Most ACCs arise in the major and minor salivary glands, nasopharynx, and lacrimal glands, but also arise from the upper respiratory tract, the lungs, the mammary gland, the skin, the mastoid air cell, and the genital tract. [1][2][3][5][6][7] ACCs account for 11% 5) or 25-30% 4) of epithelial neoplasms in the lacrimal gland. The incidence of intracranial invasion varies from 4% [1][2][3]5,6) to 22%.…”

Section: Introductionmentioning

confidence: 99%

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Adenoid Cystic Carcinoma of the Cavernous Region-Case Report-

Adachi

Yoshida

Ueda

et al. 2006

Neurol. Med. Chir.(Tokyo)

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A 62-year-old Japanese male patient presented with right oculomotor, abducens, and trigeminal nerve disturbances. Neuroimaging revealed a right middle cranial fossa mass lesion with the characteristics of trigeminal schwannoma. The patient underwent a right temporal craniotomy for gross total resection. Histological examination confirmed a metastasis of adenoid cystic carcinoma (ACC). After the operation, no evidence of the primary lesion could be found. The patient was treated with radiation therapy. ACC can be difficult to identify before histological confirmation. The incidence of intracranial invasion of ACC is 4-22%, but in this case no evidence of the primary lesion was found.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Adenoid Cystic Carcinoma of the Cavernous Region-Case Report-

Adachi

Yoshida

Ueda

et al. 2006

Neurol. Med. Chir.(Tokyo)

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Adenoid Cystic Carcinoma of the Cavernous Sinus – Otolaryngological Sequelae of Therapy: Case Report

Dzięciołowska-Baran

Gawlikowska-Sroka

2017

Advances in Experimental Medicine and Biology

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A 60-year-old woman, otherwise in a good health condition, was first admitted to the hospital with a year-long tingling sensations of the right half of the face, which gradually turned into severe neuralgia corresponding to maxillary (V2) and mandibular (V3) branches of the right trigeminal nerve. MRI scans of the head revealed an unusual hyperplastic or inflammatory changes along the brain base, cavernous sinus extending toward the pterygopalatine fossa, and lateral pterygoid on the right side. Meningioma was suspected and neuralgia was treated conservatively. About 2 years later, due to severe facial and eye pain, the patient underwent decompression of trigeminal nerve roots - Janetta's surgery. The following MRI scans revealed a tumor of cavernous sinus, arousing suspicion of malignancy. Histological specimens obtained after a biopsy and then partial transnasal tumor resection yielded a diagnosis of adenoid cystic carcinoma. The patient was treated with proton radiation therapy. The therapy caused burns in the oropharyngeal soft tissues extending from the oral cavity to the throat and esophagus. The additional adverse effect of the therapy was hypoacusis and a damage to the right cornea. A radiation-induced sinusitis appeared that required surgical intervention. The patient suffered a string of further complications, including pneumonia and a transient kidney failure. In the end, the patient survived. The adenoid carcinoma in the currently 64-year-old woman is visibly reduced, but she still suffers from the trigeminal neuralgia. The patient remains under constant laryngological outpatient care as she requires a periodic cleansing of nasal cavities and hypoacusis monitoring.

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