Intracortical recordings of early pain-related CO2-laser evoked potentials in the human second somatosensory (SII) area

Frot, Maud; Rambaud, Loı̈c; Guénot, Marc; Mauguı̀ere, François

doi:10.1016/s0168-5597(98)00054-9

Cited by 168 publications

(79 citation statements)

References 41 publications

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“…Nonetheless our data suggest the participation of the posterior insula in this ventral somatosensory cortical network, The involvement of the posterior insular cortex in the procewing of somatosensory inputs also is suggested by the fact that nociceptive responses were evoked, which, to our knowledge, had not been hitherto reported. Whereas it has long been accepted that the cerebral cortex is not directly involved in the elaboration of pain sensation, a growing number of studies based on functional neuroimaging or electrophysiology indicate that SIT and part of the insular cortex are involved in pain sensation (20,21). Our data also suggest that painful symptoms during seizures may sometimes reflect the propagation of the epileptic discharge to the insular cortex.…”

Section: Discussionmentioning

confidence: 52%

Functional Mapping of the Insular Cortex: Clinical Implication in Temporal Lobe Epilepsy

et al. 2000

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Summary: Purpose:We report the results of 75 intracortical electrical stimulations of the insular cortex performed in 14 patients during stereo-electroencephalography (SEEG) investigation of drug-resistant partial epilepsy. The insular cortex was investigated on electroclinical arguments suggesting the possibility of a perisylvian spread or a rapid multilobar diffusion of the discharges during video EEG.Methods: In these 14 patients, 27 stereotactically implanted transopercular electrodes reached the insular cortex (1 1 the right insula, 16 the left insula). Square pulses of current were applied between the two deepest adjacent contacts of each transopercular electrode using low (1 Hz) or high-frequency (50 Hz) stimulation. Only symptoms evoked in the absence of afterdischarges were analyzed.Results: Clinical responses were evoked in 10 of the 14 patients (in 20 of the 27 insular sites) and showed a clear topographic specificity inside the insular cortex. Viscerosensitive and visceromotor responses, similar to those evoked by temporomesial stimulation, were evoked by anterior insular stimulation and somesthetic sensation, similar to those evoked by opercular cortex stimulation, by posterior insular stimulation.Conclusions: The topographic organization of the induced responses within the insular cortex suggest that two different cortical networks, a visceral network extending to the temporomesial structures and a somesthetic network reaching the opercular cortex, are disturbed with stimulation of the anterior or the posterior insula, respectively. Thus ictal symptoms associated with the spread of the epileptic discharges to the insular cortex might be difficult to distinguish from those usually reported during temporomesial or opercular discharges. Key Words: Insula of Reil-Temporal lobe-Epilepsy-Stereoelectroencephalography-Stimulation.Lesional and functional data available in humans suggest that the paralimbic insular cortex is involved in visceromotor, viscerosensitive, and somesthetic functions as well as in motor, pain, and speech functions (1). The insular cortex has rarely been investigated using depth electrodes because of its anatomic location, burried under the frontal, temporal, and parietal opercular cortices and separated from them by a dense wall of arteries running in the sylvian fissure. Three previous studies are available in the literature concerning direct stimulation of the human insular cortex. Penfield and Faulk, 1955 (2), reported evoked visceromotor, viscerosensitive, gustatory, and somesthetic responses after stimulation of the inferior part of the insular cortex during intrasurgical procedures. Using stereo-electroencephalography (SEEG), Wieser, 1983 (3), concluded that 5140% of Accepted January 19, 2000. Address correspondence and reprint requests to Dr. K. Ostrowsky at Functional Neurology and Epileptology Department, H8pital Neurologique, 59 Boulevard Pinel, 69300 Lyon, France. insular cortex stimulations evoke visceral sensations. Oppenheimer et al. 1992 (4), focused on cardiac rhy...

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Section: Discussionmentioning

confidence: 52%

Functional Mapping of the Insular Cortex: Clinical Implication in Temporal Lobe Epilepsy

et al. 2000

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“…First, the early, lateralized N1 potential, maximal over contralateral temporal electrodes, and originating from operculoinsular cortex (Garcia-Larrea et al, 2003), possibly including secondary somatosensory cortex (Spiegel et al, 1996;Frot et al, 1999). Second, the bipolar vertex N2/P2 complex.…”

Section: Methodsmentioning

confidence: 99%

Visually Induced Analgesia: Seeing the Body Reduces Pain

Longo¹,

Betti²,

Aglioti³

et al. 2009

J. Neurosci.

230

272

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Given previous reports of strong interactions between vision and somatic senses, we investigated whether vision of the body modulates pain perception. Participants looked into a mirror aligned with their body midline at either the reflection of their own left hand (creating the illusion that they were looking directly at their own right hand) or the reflection of a neutral object. We induced pain using an infrared laser and recorded nociceptive laser-evoked potentials (LEPs). We also collected subjective ratings of pain intensity and unpleasantness. Vision of the body produced clear analgesic effects on both subjective ratings of pain and the N2/P2 complex of LEPs. Similar results were found during direct vision of the hand, without the mirror. Furthermore, these effects were specific to vision of one's own hand and were absent when viewing another person's hand. These results demonstrate a novel analgesic effect of non-informative vision of the body.

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“…Indeed, if one considers the possibility that LEPs and AEPs reflect, at least in part, neural activity originating from distinct cortical generators (e.g., nociceptive-specific activity possibly originating from operculo-insular cortices or auditoryspecific activity possibly originating from auditory cortex; Yvert, Fischer, Bertrand, & Pernier, 2005;Frot & Mauguiere, 2003;Godey, Schwartz, de Graaf, Chauvel, & LiegeoisChauvel, 2001;Frot, Rambaud, Guenot, & Mauguiere, 1999;Giard et al, 1994), then the observed results could be explained by refractoriness of these cortical generators.…”

Section: Bottom-up Effect Of Introducing a Change In Sensory Modalitymentioning

confidence: 99%

Dishabituation of Laser-evoked EEG Responses: Dissecting the Effect of Certain and Uncertain Changes in Stimulus Modality

Valentini

Torta

Mouraux

et al. 2011

Journal of Cognitive Neuroscience

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Abstract■ The repetition of nociceptive stimuli of identical modality, intensity, and location at short and constant interstimulus intervals (ISIs) determines a strong habituation of the corresponding EEG responses, without affecting the subjective perception of pain. To understand what determines this response habituation, we (i) examined the effect of introducing a change in the modality of the repeated stimulus, and (ii) dissected the relative contribution of bottom-up, stimulus-driven changes in modality and top-down, cognitive expectations of such a change, on both laser-evoked and auditory-evoked EEG responses. Multichannel EEG was recorded while participants received trains of three stimuli (S1-S2-S3, a triplet) delivered to the hand dorsum at 1-sec ISI. S3 belonged either to the same modality as S1 and S2 or to the other modality. In addition, participants were either explicitly informed or not informed of the modality of S3. We found that introducing a change in stimulus modality produced a significant dishabituation of the laser-evoked N1, N2, and P2 waves; the auditory N1 and P2 waves; and the laser-and auditory-induced event-related synchronization and desynchronization. In contrast, the lack of explicit knowledge of a possible change in the sensory modality of the stimulus (i.e., uncertainty) only increased the ascending portion of the laser-evoked and auditory-evoked P2 wave. Altogether, these results indicate that bottom-up novelty resulting from the change of stimulus modality, and not topdown cognitive expectations, plays a major role in determining the habituation of these brain responses. ■

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Intracortical recordings of early pain-related CO2-laser evoked potentials in the human second somatosensory (SII) area

Cited by 168 publications

References 41 publications

Functional Mapping of the Insular Cortex: Clinical Implication in Temporal Lobe Epilepsy

Functional Mapping of the Insular Cortex: Clinical Implication in Temporal Lobe Epilepsy

Visually Induced Analgesia: Seeing the Body Reduces Pain

Dishabituation of Laser-evoked EEG Responses: Dissecting the Effect of Certain and Uncertain Changes in Stimulus Modality

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