Dishabituation of Laser-evoked EEG Responses: Dissecting the Effect of Certain and Uncertain Changes in Stimulus Modality

Valentini, Elia; Torta, Diana; Mouraux, André; Iannetti, Gian Domenico

doi:10.1162/jocn.2011.21609

Cited by 62 publications

(85 citation statements)

References 60 publications

(69 reference statements)

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“…Indeed, a recent study suggests that the population response to expected and unexpected events may best be explained by a combination of prediction-and prediction-error-related responses (Egner et al, 2010). Generally, our findings are well in line with earlier work that has shown that probability can have large effects on early cortical processing in the auditory cortex, both in nonhuman (Ulanovsky et al, 2003) and human (Haenschel et al, 2000(Haenschel et al, , 2005Weiland et al, 2008;Valentini et al, 2011) primates.…”

Section: Discussionsupporting

confidence: 91%

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Prior Expectation Mediates Neural Adaptation to Repeated Sounds in the Auditory Cortex: An MEG Study

Todorović

Ede²,

Maris³

et al. 2011

Journal of Neuroscience

370

349

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Repetition suppression, the phenomenon that the second presentation of a stimulus attenuates neural activity, is typically viewed as an automatic consequence of repeated stimulus presentation. However, a recent neuroimaging study has suggested that repetition suppression may be driven by top-down expectations. Here we examined whether and when repetition suppression can be modulated by top-down expectation. Participants listened to auditory stimuli in blocks where tone repetitions were either expected or unexpected, while we recorded ongoing neural activity using magnetoencephalography. We found robust repetition suppression in the auditory cortex for repeated tones. Interestingly, this reduction was significantly larger for expected than unexpected repetitions, both in terms of evoked activity and gamma-band synchrony. These findings indicate a role of top-down expectation in generating repetition suppression and are in line with predictive coding models of perception, in which the difference between expected and actual input is propagated from lower to higher cortical areas.

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Section: Discussionsupporting

confidence: 91%

“…In this sense, the gammaband activity we observed may signal a "prediction error" response. This response should therefore not be confused with the expectancy state itself, which is expressed in the temporal structure of activity patterns before the appearance of stimuli (Engel et al, 2001;van Ede et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Prior Expectation Mediates Neural Adaptation to Repeated Sounds in the Auditory Cortex: An MEG Study

Todorović

Ede²,

Maris³

et al. 2011

Journal of Neuroscience

370

349

View full text Add to dashboard Cite

show abstract

“…However, we were unable to determine which of these stimulus attributes are determinant in causing response habituation. In two subsequent experiments we showed that introducing a selective change in the sensory modality of the stimulus produced a significant dishabituation of the ERPs (Valentini et al 2011), whereas introducing a selective change in its spatial location did not (Torta et al 2012). These findings suggest that different attributes defining a stimulus are not equally effective in inducing a dishabituation of the ERP response.…”

Section: Leps: Saliency Vs Noveltymentioning

confidence: 87%

“…However, by exploring the LEP dishabituation triggered by introducing selective changes of stimulus location or modality (i.e., two of the four basic attributes defining a sensory stimulus) we showed that LEPs are highly sensitive to bottom-up, stimulus-driven factors such as novelty (Torta et al 2012;Valentini et al 2011). Importantly, the design of these previous experiments did not allow differentiating between the respective effects of novelty and saliency in determining LEP dishabituation.…”

mentioning

confidence: 90%

Novelty is not enough: laser-evoked potentials are determined by stimulus saliency, not absolute novelty

Ronga

Valentini

Mouraux

et al. 2013

Journal of Neurophysiology

108

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related potentials (ERPs) elicited by transient nociceptive stimuli in humans are largely sensitive to bottom-up novelty induced, for example, by changes in stimulus attributes (e.g., modality or spatial location) within a stream of repeated stimuli. Here we aimed 1) to test the contribution of a selective change of the intensity of a repeated stimulus in determining the magnitude of nociceptive ERPs, and 2) to dissect the effect of this change of intensity in terms of "novelty" and "saliency" (an increase of stimulus intensity is more salient than a decrease of stimulus intensity). Nociceptive ERPs were elicited by trains of three consecutive laser stimuli (S1-S2-S3) delivered to the hand dorsum at a constant 1-s interstimulus interval. Three, equally spaced intensities were used: low (L), medium (M), and high (H). While the intensities of S1 and S2 were always identical (L, M, or H), the intensity of S3 was either identical (e.g., HHH) or different (e.g., MMH) from the intensity of S1 and S2. Introducing a selective change in stimulus intensity elicited significantly larger N1 and N2 waves of the S3-ERP but only when the change consisted in an increase in stimulus intensity. This observation indicates that nociceptive ERPs do not simply reflect processes involved in the detection of novelty but, instead, are mainly determined by stimulus saliency. habituation; pain; electroencephalography; stimulus intensity BRIEF INFRARED LASER HEAT pulses selectively activate A␦ and C fiber skin nociceptors in the superficial skin layers (Bromm and Treede 1984). Such stimuli elicit transient event-related potentials [laser-evoked potentials (LEPs)], related to the activation of A␦ nociceptors. The largest LEP wave is a negative-positive complex maximal at the scalp vertex (N2-P2). This complex is preceded by a smaller negative wave (N1) maximal over the central-temporal region contralateral to the stimulated hand (Bromm and Treede 1984;Hu et al. 2010;Valentini et al. 2012). These waves reflect a combination of cortical activities originating from primary and secondary somatosensory cortices, the insula, and the anterior cingulate cortex (Garcia-Larrea et al. 2003;Valentini et al. 2012).Although widely used to investigate the function of nociceptive pathways in health and disease (Haanpaa et al. 2011), the physiological meaning of LEPs is still debated. Indeed, recent experimental evidence indicates that LEPs may reflect stimulus-triggered brain processes largely unspecific for nociception. Indeed, similar brain responses can be elicited by nonnociceptive sensory stimuli that are never perceived as painful, provided that they are salient (Legrain et al. 2011;Mouraux and Iannetti 2009). Furthermore, the well-known positive correlation between the intensity of perceived pain and the magnitude of LEPs can be disrupted in several experimental conditions, such as stimulus repetition at a short and constant interval Treede et al. 2003;Wang et al. 2010).Finally, there is a large amount of evidence that the main LEP waves can be modu...

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“…Mouraux et al 2011). Further evidence that the so-called pain-related brain responses are not specific for pain perception, but depend on presentation context and on stimulus predictability and novelty comes from the studies by Clark et al (2008), Iannetti et al (2008), Wang et al (2010) and Valentini et al (2011).…”

Section: 3mentioning

confidence: 99%

Linguistic synaesthesia, perceptual synaesthesia, and the interaction between multiple sensory modalities

Ronga

Bazzanella

Rossi

et al. 2012

P&C

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Recent studies on cortical processing of sensory information highlight the importance of multisensory integration, and define precise rules governing reciprocal influences between inputs of different sensory modalities. We propose that psychophysical interactions between different types of sensory stimuli and linguistic synaesthesia share common origins and mechanisms. To test this hypothesis, we compare neurophysiological findings with corpus-based analyses relating to linguistic synaesthesia. Namely, we present Williams' hypothesis and its recent developments about the hierarchy of synaesthetic pairings, and examine critical aspects of this theory concerning universality, directionality, sensory categories, and usage of corpora. These theoretical issues are verified against linguistic data derived from corpus-based analyses of Italian synaesthetic pairings related to auditory and tactile modalities. Our findings reveal a strong parallel between linguistic synaesthesia and neurophysiological interactions between different sensory stimuli, suggesting that linguistic synaesthesia is affected by tendencies similar to the rules underlying the perceptual association of distinct sensory modalities.

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Dishabituation of Laser-evoked EEG Responses: Dissecting the Effect of Certain and Uncertain Changes in Stimulus Modality

Cited by 62 publications

References 60 publications

Prior Expectation Mediates Neural Adaptation to Repeated Sounds in the Auditory Cortex: An MEG Study

Prior Expectation Mediates Neural Adaptation to Repeated Sounds in the Auditory Cortex: An MEG Study

Novelty is not enough: laser-evoked potentials are determined by stimulus saliency, not absolute novelty

Linguistic synaesthesia, perceptual synaesthesia, and the interaction between multiple sensory modalities

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