Intracerebroventricular administration of colchicine produces cognitive impairment associated with oxidative stress in rats

Kumar, Mukesh; Gupta, Yogendra Kumar

doi:10.1016/s0091-3057(02)00838-9

Cited by 66 publications

(19 citation statements)

References 42 publications

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“…Central administration of colchicines caused increased in ROS generation, cognitive dysfunction, microtubule dysfunction and loss of cholinergic neurons in brain [316, 317]. In a recent study, the effect of curcumin against colchicines-induced cognitive and oxidative stress was determined in Wistars rats and compared with rivastigmine treatment.…”

Section: Neuroprotective Action Of Curcumin Against Admentioning

confidence: 99%

Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century

et al. 2013

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Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is widely used in Southeast Asia, China and India in food preparation and for medicinal purposes. Since the second half of the last century, this traditional medicine has attracted the attention of scientists from multiple disciplines to elucidate its pharmacological properties. Of significant interest is curcumin’s role to treat neurodegenerative diseases including Alzheimer’s disease (AD), and Parkinson’s disease (PD) and malignancy. These diseases all share an inflammatory basis, involving increased cellular reactive oxygen species (ROS) accumulation and oxidative damage to lipids, nucleic acids and proteins. The therapeutic benefits of curcumin for these neurodegenerative diseases appear multifactorial via regulation of transcription factors, cytokines and enzymes associated with (Nuclear factor kappa beta) NFκB activity. This review describes the historical use of curcumin in medicine, its chemistry, stability and biological activities, including curcumin's anti-cancer, anti-microbial, anti-oxidant, and anti-inflammatory properties. The review further discusses the pharmacology of curcumin and provides new perspectives on its therapeutic potential and limitations. Especially, the review focuses in detail on the effectiveness of curcumin and its mechanism of actions in treating neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases and brain malignancies.

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Section: Neuroprotective Action Of Curcumin Against Admentioning

confidence: 99%

Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century

et al. 2013

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“…Cut-off time was fixed as 300 seconds and in case a rat could not find the closed arm within this period, it was removed from the maze and rejected. Second trial (retention trial) was performed 24 hrs after the acquisition trial and retention transfer latency was noted (Sharma and Gupta, 2002;Veerendra Kumar and Gupta, 2002) similarly. The retention trial latency was expressed as percentage of initial trial latency.…”

Section: Elevated Plus Maze Testmentioning

confidence: 99%

“…Twenty-four hours later, retention trial was performed and retention latency (RL) to step into the dark compartment was noted (post-shock latency). Cut-off time was fixed at 300 seconds (Sharma and Gupta, 2002;Veerendra Kumar and Gupta, 2002). The retention trial latency was expressed as percentage of initial trial latency.…”

Section: Elevated Plus Maze Testmentioning

confidence: 99%

Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats

et al. 2005

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“…(3) The intracerebroventricular administration of colchicine in rats produces cognitive impairment and oxidative stress by disrupting the microtubule assembly and this method can be effectively used as an animal model for AD. (4–6) The most logical route toward therapeutic intervention for neurodegenerative diseases involves the identification of small molecules that have the ability to provide neuroprotection. For example, acetaminophen protects hippocampal neurons and PC12 cultures from Aβ peptide-induced oxidative stress through reduction of lipid peroxidation and by lowering cytoplasmic levels of peroxides.…”

Section: Introductionmentioning

confidence: 99%

Nootropic activity of acetaminophen against colchicine induced cognitive impairment in rats

Pitchaimani¹,

Arumugam²,

Thandavarayan³

et al. 2012

J. Clin. Biochem. Nutr.

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Alzheimer’s disease is a devastating neurodegenerative disorder, the most common among the dementing illnesses. Acetaminophen has gaining importance in neurodegenerative diseases by attenuating the dopaminergic neurodegeneration in Caenorhabditis elegans model, decreasing the chemokines and the cytokines and increasing the anti apoptotic protein such as Bcl-2 in neuronal cell culture. The low concentration acetaminophen improved the facilitation to find the hidden platform in Morris Water Maze Test. Also some data suggest that acetaminophen could contribute in neurodegeneration. The present study was aimed to evaluate the effect of acetaminophen against colchicine induced cognitive impairment and oxidative stress in wistar rats. The cognitive learning and memory behaviour was assessed using step through passive avoidance paradigm and acetylcholine esterase activity. The parameters of oxidative stress were assessed by measuring the malondialdehyde, reduced glutathione and catalase levels in the whole brain homogenates. There was a significant memory improvement in the rats received acetaminophen treatment and it has also decreased the acetylcholine esterase enzyme level, confirming its nootropic activity. Acetaminophen neither increases nor decreases the reduced glutathione and catalase in the whole brain homogenates, showing that acetaminophen is devoid of any adverse effect on brain antioxidant defense system.

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Intracerebroventricular administration of colchicine produces cognitive impairment associated with oxidative stress in rats

Cited by 66 publications

References 42 publications

Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century

Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century

Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats

Nootropic activity of acetaminophen against colchicine induced cognitive impairment in rats

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