Intracerebral haematoma in an infant with haemophilia A

Abstract

A nine-weeks-old infant with haemophilia A developed an intracerebral haematoma. Intracranial operation and removal of the haematoma were performed safely under the cover of highly potent AHF cryoprecipitate. Computerized tomography of the brain is very useful for neurosurgical care of the haemophiliac patients as a noninvasive and atraumatic method of examination. The literature of intracranial operations in infants with haemophilia A under the age of one year is reviewed.

Spontaneous Intracerebral Hemorrhage in Pediatric Patients with Hemophilia A: Case Report and Review of Perioperative Management of Clotting Factor Concentrates

“…To avoid hypervolemia and brain edema, Carrea, et al developed FIOta (tannic acid precipitate of Blombäck's FI-O fraction), a factor VIII preparation ten times more concentrated than human plasma [15]. Cryoprecipitate later emerged as the mainstay of treatment, demonstrating efficacy in elevating Factor VIII activity levels perioperatively for neurosurgical intervention in ICH with safe evacuation of hematomas [16,17]. Cryoprecipitate, however, had varying levels of Factor VIII depending on its preparation [16].…”

Spontaneous intracranial haemorrhage as initial presentation of haemophilia in infants and children: A case report and systematic literature review

“…However, an intracranial haemorrhage (ICH) is the most severe event, which results in significant morbidity and can even be life-threatening. [1][2][3] However, little is known about spontaneous ICH in children older than 1 month of age and certainly about ICH as a first presentation. We performed a systematic literature review of spontaneous ICH in haemophilia children beyond the neonatal period and without inhibitor, supplemented with an additional case.…”