Spontaneous intracranial haemorrhage as initial presentation of haemophilia in infants and children: A case report and systematic literature review

Rohaert, Celine; Labarque, Veerle

doi:10.1111/hae.14239

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…However, the risk was found to be higher in assisted delivery such as forceps and vacuum There is increased mortality and even more increased morbidity in hemophiliac patients with ICH. The long term neurological follow-up is mandatory in these patients (27,28). Our patients had serious morbidity and they are still being followed up in terms of neurological deficits.…”

Section: Discussionmentioning

confidence: 90%

Intracranial hemorrhage in children with hemophilia

Akyol¹,

GÖL²,

Yılmaz³

et al. 2022

J. Transl. Pract. Med.

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Aim: Hemophilias are inherited bleeding disorders, in which the patients generally present with clinical complaints of hemarthrosis. Intracranial hemorrhage (ICH) is one of the severe bleeding types with the highest mortality and morbidity throughout childhood, as well as in patients with a diagnosis of hemophilia. Herein, a single-center experience of intracranial hemorrhage in children with hemophilia is presented. Materials and Methods: The files and hospital records of the patients with the diagnosis of hemophilia who were followed up by the Pediatric Hematology and Oncology Department of Erciyes University between the years 1993-2022 were evaluated retrospectively. Results: A total of 81 patients with hemophilia were evaluated. Among them, 9 patients developed ICH. All patients had severe diseases. The mean age of incidence ICH was 2,6 months (4 days- 8,7 months). All the ICH episodes were observed within the first year of life. Four patients were diagnosed with the ICH episode initially. None of the patients had primary prophylaxis. The majority of them were admitted with neurological signs and symptoms. There was no ICH-related mortality in our study and all of the patients are being followed up in our department. Conclusion: Intracranial hemorrhage remains important in patients with congenital bleeding disorders, especially in hemophilia; with difficulties in diagnosis, management, and treatment.

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Section: Discussionmentioning

confidence: 90%