1998
DOI: 10.1177/10454411980090010301
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Intracellular Transport and Secretion of Salivary Proteins

Abstract: Intracellular transport and secretion of salivary proteins are major activities of salivary acinar cells. While the major intracellular pathway followed by salivary proteins following their synthesis has been described previously, there is only limited understanding of how this process is regulated at the molecular level. Studies of salivary proteins, especially proline-rich proteins, expressed in an endocrine cell line have begun to provide insight regarding intermolecular interactions during transport and th… Show more

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Cited by 109 publications
(87 citation statements)
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References 98 publications
(113 reference statements)
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“…Normally, hGH is secreted from somatotrophs in the anterior pituitary via the regulated pathway, which leads to secretion into the bloodstream. However, as noted above, regulated pathway secretion from salivary glands leads to secretion into saliva (Castle and Castle, 1998). Indeed, although both Goldfine et al (1997) and He et al (1998) showed the presence of hGH in serum after gene transfer, we later reported (Baum et al, 1999) that at the adenoviral vector doses used by He et al (5 Â 10 9 plaque forming units) the amount of hGH secreted into saliva after gene transfer was about nine times the amount found in the bloodstream.…”
Section: Endocrine Sectreion Of Transgene Encoded Proteinsmentioning
confidence: 84%
See 1 more Smart Citation
“…Normally, hGH is secreted from somatotrophs in the anterior pituitary via the regulated pathway, which leads to secretion into the bloodstream. However, as noted above, regulated pathway secretion from salivary glands leads to secretion into saliva (Castle and Castle, 1998). Indeed, although both Goldfine et al (1997) and He et al (1998) showed the presence of hGH in serum after gene transfer, we later reported (Baum et al, 1999) that at the adenoviral vector doses used by He et al (5 Â 10 9 plaque forming units) the amount of hGH secreted into saliva after gene transfer was about nine times the amount found in the bloodstream.…”
Section: Endocrine Sectreion Of Transgene Encoded Proteinsmentioning
confidence: 84%
“…In mammalian salivary glands, there exist multiple pathways for protein secretion including both classical constitutive (across the basolateral membranes towards the interstitium and bloodstream) and regulated (across the apical membrane into the forming saliva) secretory pathways, as well as additional variants (Castle and Castle, 1998). It has been suggested that sorting mechanisms in exocrine cells, like those found in salivary glands, are more promiscuous than in neuroendocrine cells (Gorr et al, 2001).…”
Section: Pathways For Protein Secretionmentioning
confidence: 99%
“…Several distinct protein secretion pathways have been identified in salivary gland cells, within the general constitutive and RSP categories, including both major and minor regulated pathways, apical and basolateral constitutive pathways, and a constitutive-like pathway [9,15]. These lead to specific sorting routes for transgenic secretory proteins in an endocrine and exocrine manner [16].…”
Section: Introductionmentioning
confidence: 99%
“…Clearly, in rats hPTH sorted primarily toward the apical membrane and on immunofluorescent staining hPTH was found in the apical region of salivary epithelial cells. The exact pathways used to achieve this apical secretion of hPTH remain to be elucidated, and could involve the major regulated secretory pathway (dense-core granules) (Castle and Castle, 1998), as well as the minor regulated and constitutive-like secretory pathways, both of which originate in immature secretory granules (Castle and Castle, 1996). Given the amount of hPTH produced by the transduced rat submandibular glands, the hPTH secretion found in serum may in part result from a spillover effect due to saturation of the apical pathway (Marmorstein et al, 2000).…”
Section: Figmentioning
confidence: 99%
“…This regimen is expensive and is not physiologically ideal, providing a strong rationale for a more effective delivery system. We propose to take advantage of the efficient protein-producing capacity of the salivary glands (Castle and Castle, 1998). Salivary glands are an attractive target tissue for gene transfer .…”
mentioning
confidence: 99%