Intracellular second messengers mediate stress inducible hormesis and Programmed Cell Death: A review

Zhou, David R.; Eid, Rawan; Miller, Katie A.; Boucher, Éric; Mandato, Craig A.; Greenwood, Michael T.

doi:10.1016/j.bbamcr.2019.01.016

Cited by 38 publications

(19 citation statements)

References 418 publications

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“…Increasing evidence indicate the role of ROS as secondary messengers in the initiation and amplification of cell signaling, which have key roles in cell proliferation, apoptosis, oxidative damage of cells, and inflammation. 106,107 More specifically, imbalances in ROS homeostasis may lead to oxidation-anti-oxidation imbalance, increase oxidative stress, and result in oxidative damage to biological macromolecules such as lipids, DNA, and proteins. 108 ROS have also been reported as key mediators of inflammation.…”

Section: Mechanisms and Pathways That Mediate The Antioxidant Anti-imentioning

confidence: 99%

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Xu¹,

Chen²

2020

JIR

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Nesfatin-1, a newly identified energy-regulating peptide, is widely expressed in the central and peripheral tissues, and has a variety of physiological activities. A large number of recent studies have shown that nesfatin-1 exhibits antioxidant, antiinflammatory, and anti-apoptotic properties and is involved in the occurrence and progression of various diseases. This review summarizes current data focusing on the therapeutic effects of nesfatin-1 under different pathophysiological conditions and the mechanisms underlying its antioxidant, anti-inflammatory, and anti-apoptotic activities.

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Section: Mechanisms and Pathways That Mediate The Antioxidant Anti-imentioning

confidence: 99%

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Xu¹,

Chen²

2020

JIR

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“…Two main signalling stress mediators, and eventual inducers of cell death and apoptosis, are represented by a sustained cytosolic Ca 2+ rise and reactive oxygen species (ROS) production [ 24 ]. The duration and intensity of these well-known stress signals are the key factors for an adequate cell response to dangers the cells are facing or, if too prolonged in time and/or too severe in its intensity, are the means to induce cell death, indicating the inability of the cells to overcome the challenge they are facing.…”

Section: Resultsmentioning

confidence: 99%

“…Since another important stress signal activating cell death pathways is intracellular ROS production, directly or indirectly stimulated by the extracellular stimulus/danger or by the Ca 2+ second messenger rise, respectively [ 24 , 27 ], also this parameter was investigated in L929 and RAW 264.7 cells by using the ROS sensitive dye 2′,7′-dichlorodihydrofluorescein diacetate (DCF) and fluorometric analysis ( Figure 7 E,F). The analysis was performed either in the presence or absence of extracellular Ca 2+ in the cell medium.…”

Section: Resultsmentioning

confidence: 99%

Identification, Purification and Molecular Characterization of Chondrosin, a New Protein with Anti-tumoral Activity from the Marine Sponge Chondrosia Reniformis Nardo 1847

et al. 2020

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Chondrosia reniformis is a common marine demosponge showing many peculiarities, lacking silica spicules and with a body entirely formed by a dense collagenous matrix. In this paper, we have described the identification of a new cytotoxic protein (chondrosin) with selective activity against specific tumor cell lines, from C. reniformis, collected from the Liguria Sea. Chondrosin was extracted and purified using a salting out approach and molecular weight size exclusion chromatography. The cytotoxic fractions were then characterized by two-dimensional gel electrophoresis and mass spectrometry analysis and matched the results with C. reniformis transcriptome database. The procedure allowed for identifying a full-length cDNA encoding for a 199-amino acids (aa) polypeptide, with a signal peptide of 21 amino acids. The mature protein has a theoretical molecular weight of 19611.12 and an IP of 5.11. Cell toxicity assays showed a selective action against some tumor cell lines (RAW 264.7 murine leukemia cells in particular). Cell death was determined by extracellular calcium intake, followed by cytoplasmic reactive oxygen species overproduction. The in silico modelling of chondrosin showed a high structural homology with the N-terminal region of the ryanodine receptor/channel and a short identity with defensin. The results are discussed suggesting a possible specific interaction of chondrosin with the Cav 1.3 ion voltage calcium channel expressed on the target cell membranes.

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“…In cells, metabolic processes physiologically produce ROS that cause oxidative damage to DNA (16), and this physiological production of ROS is associated with aging of the brain and neurodegeneration. Under physiological conditions, ROS may act as a second messenger in cells (17). ROS controls several physiological processes, such as the hypoxic response and inflammation, as well as the regulation of growth factor signaling (18).…”

Section: Role Of Ros In the Pathogenesis Of Dementiamentioning

confidence: 99%

Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review)

et al. 2020

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Dementia is a failure of cognitive ability characterized by severe neurodegeneration in select neural systems, and Alzheimer's disease (AD) is the most common type of neurodegenerative disease. Although numerous studies have provided insights into the pathogenesis of AD, the underlying signaling and molecular pathways mediating the progressive decline of cognitive function remain poorly understood. Recent progress in molecular biology has provided an improved understanding of the importance of molecular pathogenesis of AD, and has proposed an association between DNA repair mechanisms and AD. In particular, the fundamental roles of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) and breast cancer gene 1 (BRCA1) tumor suppressors have been shown to regulate the pathogenesis of neurodegeneration. Consequently, onset of neurodegenerative diseases may be deferred with the use of dietary neuroprotective agents which alter the signaling mediated by the aforementioned tumor suppressors. In a healthy neuron, homeostasis of key intracellular molecules is of great importance, and preventing neuronal apoptosis is one of the primary goals of treatments designed for dementia-associated diseases. In the present review, progress into the understanding of dietary regulation for preventing or limiting development of dementia is discussed with a focus on the modulatory roles of PTEN and BRCA1 signaling.

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Intracellular second messengers mediate stress inducible hormesis and Programmed Cell Death: A review

Cited by 38 publications

References 418 publications

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Identification, Purification and Molecular Characterization of Chondrosin, a New Protein with Anti-tumoral Activity from the Marine Sponge Chondrosia Reniformis Nardo 1847

Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review)

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