Intracellular redistribution of heme in rat liver under oxidative stress: the role of heme synthesis*

Kaliman, Pavel A.; Бараннік, Т. В.; Strel'chenko, E. V.; Inshina, Natalya; Sokol, O. A.

doi:10.1016/j.cellbi.2004.11.004

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…The stimulatory effect of phenylhydrazine was also seen on the heme oxygenase, which is in agreement with many other studies [9], [39]. The enzyme is a rate-limiting enzyme for heme degradation or bilirubin synthesis [7].…”

Section: Discussionsupporting

confidence: 92%

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Inhibitory Effects of Palm Tocotrienol-Rich Fraction Supplementation on Bilirubin-Metabolizing Enzymes in Hyperbilirubinemic Adult Rats

Kamisah

Lim

et al. 2014

PLoS ONE

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BackgroundPhenylhydrazine, a hemolytic agent, is widely used as a model of experimental hyperbilirubinemia. Palm tocotrienol-rich fraction (TRF) was shown to exert beneficial effects in hyperbilirubinemic rat neonates.AimTo investigate the effects of palm TRF supplementation on hepatic bilirubin-metabolizing enzymes and ocidative stress status in rats administered phenylhydrazine.MethodsTwenty-four male Wistar rats were divided into two groups; one group was intraperitoneally injected with palm TRF at the dose of 30 mg/kg/day, while another group was only given vehicle (control) (vitamin E-free palm oil) for 14 days. Twenty-four hours after the last dose, each group was further subdivided into another two groups. One group was administered phenylhydrazine (100 mg/kg, intraperitoneally) and another group was administered normal saline. Twenty-four hours later, blood and liver were collected for biochemical parameter measurements.ResultsPhenylhydrazine increased plasma total bilirubin level and oxidative stress in the erythrocytes as well as in the liver, which were reduced by the pretreatment of palm TRF. Palm TRF also prevented the increases in hepatic heme oxygenase, biliverdin reductase and UDP-glucuronyltransferase activities induced by phenylhydrazine.ConclusionPalm tocotrienol-rich fraction was able to afford protection against phenylhydrazine-induced hyperbilirubinemia, possibly by reducing oxidative stress and inhibiting bilirubin-metabolizing enzymes in the liver.

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Section: Discussionsupporting

confidence: 92%

“…No study so far had reported the effect of tocotrienol on the enzyme. α-Tocopherol on this other hand, failed to prevent the enzyme inhibition by CdCl 2 [39].…”

Section: Discussionmentioning

confidence: 89%

Inhibitory Effects of Palm Tocotrienol-Rich Fraction Supplementation on Bilirubin-Metabolizing Enzymes in Hyperbilirubinemic Adult Rats

Kamisah

Lim

et al. 2014

PLoS ONE

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“…The OxyR and SoxR regulators mainly control E. coli defense against oxidative stress. Interestingly, H 2 O 2 activate genes of both regulons: OxyR (about 30 genes) and SoxRS (about 17 genes) 18 . It was demonstrated that nitric oxide and its derivatives (NOs) as well as S -nitrosothiols (SNOs) may be involved in signaling in bacteria and may change properties of several bacterial proteins including OxyR, SoxR, NorR and Fur in Escherichia coli 19–22 , as well as ResDE in Bacillus subtilis 23 .…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Shiga toxin-converting bacteriophage development by novel antioxidant compounds

Bloch

Nejman-Faleńczyk

Pierzynowska

et al. 2018

Journal of Enzyme Inhibition and Medicinal Chemistry

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Oxidative stress may be the major cause of induction of Shiga toxin-converting (Stx) prophages from chromosomes of Shiga toxin-producing Escherichia coli (STEC) in human intestine. Thus, we aimed to test a series of novel antioxidant compounds for their activities against prophage induction, thus, preventing pathogenicity of STEC. Forty-six compounds (derivatives of carbazole, indazole, triazole, quinolone, ninhydrine, and indenoindole) were tested. Fifteen of them gave promising results and were further characterized. Eleven compounds had acceptable profiles in cytotoxicity tests with human HEK-293 and HDFa cell lines. Three of them (selected for molecular studies) prevent the prophage induction at the level of expression of specific phage genes. In bacterial cells treated with hydrogen peroxide, expression of genes involved in the oxidative stress response was significantly less efficient in the presence of the tested compounds. Therefore, they apparently reduce the oxidative stress, which prevents induction of Stx prophage in E. coli.

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Expression profiles of the genes associated with metabolism and transport of amino acids and their derivatives in rat liver regeneration

Chang

2007

Amino Acids

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Amino acids (AA) are components of protein and precursors of many important biological molecules. To address effects of the genes associated with metabolism and transport of AA and their derivatives during rat liver regeneration (LR), we firstly obtained the above genes by collecting databases data and retrieving related thesis, and then analyzed their expression profiles during LR using Rat Genome 230 2.0 array. The LR-associated genes were identified by comparing the gene expression difference between partial hepatectomy (PH) and sham-operation (SO) rat livers. It was approved that 134 genes associated with metabolism of AA and their derivatives and 26 genes involved in transport of them were LR-associated. The initially and totally expressing number of these genes occurring in initial phase of LR (0.5-4 h after PH), G0/G1 (4-6 h after PH), cell proliferation (6-66 h after PH), cell differentiation and structure-function reconstruction of liver tissue (72-168 h after PH) were respectively 76, 17, 79, 5 and 162, 89, 564, 195, illustrating that these LR-associated genes were initially expressed mainly in initial stage, and functioned in different phases. Frequencies of up-regulation and down-regulation of them being separately 564 and 357 demonstrated that genes up-regulated outnumbered those down-regulated. Categorization of their expression patterns into 22 types implied the diversity of cell physiological and biochemical activities. According to expression changes and patterns of the above-mentioned genes in LR, it was presumed that histidine biosynthesis in the metaphase and anaphase, valine metabolism in the anaphase, and metabolism of glutamate, glutamine, asparate, asparagine, methionine, alanine, leucine and aromatic amino acid almost were enhanced in the whole LR; as for amino acid derivatives, transport of neutral amino acids, urea, gamma-aminobutyric acid, betaine and taurine, metabolism of dopamine, heme, S-adenosylmethionine, thyroxine, and biosynthesis of hydroxyproline, nitric oxide, orinithine, polyamine, carnitine, selenocysteine were augmented during the entire liver restoration. Above results showed that metabolism and transport of AA and their derivates were necessary in liver regeneration.

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Intracellular redistribution of heme in rat liver under oxidative stress: the role of heme synthesis*

Cited by 6 publications

References 27 publications

Inhibitory Effects of Palm Tocotrienol-Rich Fraction Supplementation on Bilirubin-Metabolizing Enzymes in Hyperbilirubinemic Adult Rats

Inhibitory Effects of Palm Tocotrienol-Rich Fraction Supplementation on Bilirubin-Metabolizing Enzymes in Hyperbilirubinemic Adult Rats

Inhibition of Shiga toxin-converting bacteriophage development by novel antioxidant compounds

Expression profiles of the genes associated with metabolism and transport of amino acids and their derivatives in rat liver regeneration

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