Intracellular Messengers in Stimulus-Secretion Coupling of Pancreatic Acinar Cells

Schulz, Irene; Streb, Hanspeter; Bayerdörffer, Eckehard; Imamura, Kensaburo

doi:10.1097/00005344-198600088-00019

Cited by 5 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…InsP3 and InsP4 in turn regulate Ca2m obilization, both the release from intracellular stores and influx from the extracellular medium (Putney, 1988;Berridge, 1993). The elevated cytosolic Ca2+ and DG are associated with the activation of their respective protein kinases, calmodulin and protein kinase C, to phosphorylate zymogen granular membrane regulatory proteins, resulting in exocytosis and secretion (Burnham & Williams, 1982;Schulz et al 1986). In contrast, activation of membrane-bound adenylate cyclase results in an elevation of endogenous cyclic AMP, which in turn stimulates protein kinase A. Cyclic AMP-dependent protein kinase in turn phosphorylates zymogen granular membrane proteins, resulting in exocytosis and enzyme secretion (Jensen & Gardner, 1981;Burnham & Williams, 1982;Petersen, 1982).…”

Section: Discussionmentioning

confidence: 99%

Interaction between secretin and nerve‐mediated amylase secretion in the isolated exocrine rat pancreas

Wisdom¹,

Camello²,

Salido³

et al. 1994

Experimental Physiology

View full text Add to dashboard Cite

SUMMARYThis study investigates the effects of the gut peptide, secretin, on nerve-mediated and acetylcholine-evoked amylase secretion and calcium (Ca2") and magnesium (Mg2") mobilization in the in vitro rat pancreas. Both electrical field stimulation (EFS; 50 V, 20 Hz, 1 ms) and acetylcholine (ACh; 10-6 M) caused marked increases in amylase output in isolated pancreatic segments. These responses were inhibited by atropine (10-`M). Secretin (10-'°and 108 M) evoked only a small increase in amylase secretion, which was unaffected by atropine. Combining either EFS or ACh with secretin resulted in an attenuation in amylase output compared with the response obtained with either EFS or ACh alone. In a Mg2"-free medium, secretin failed to inhibit the amylase output evoked by EFS. When forskolin (10-5M) was combined with EFS there was a marked potentiation of amylase output. In fura-2-loaded acinar cells, ACh (10-6 M)

show abstract

Section: Discussionmentioning

confidence: 99%

Interaction between secretin and nerve‐mediated amylase secretion in the isolated exocrine rat pancreas

Wisdom¹,

Camello²,

Salido³

et al. 1994

Experimental Physiology

View full text Add to dashboard Cite

show abstract

“…The overall rise in intracellular calcium is finally associated with the activation of the calcium-dependent proteinkinase calmodulin which, the same as proteinkinase C, phosphorylates zymogen granular membrane proteins resulting in swelling of the granules, migration and docking, fusion with the luminal membrane, exocytosis and, subsequently, secretion of digestive enzymes (60,76). Going back to calcium, it is noteworthy that the increasing conviction that it plays a vital role as intracellular messenger has overshadowed the role of another divalent cation, magnesium.…”

Section: Adaptation To Dietary Fatmentioning

confidence: 99%

Adaptation of the exocrine pancreas to dietary fats

et al. 2000

View full text Add to dashboard Cite

This article reviews studies on the adaptation of the exocrine pancreas to dietary fat. We include all the latest information about the mechanisms that underlie the adaptation of the secretory mechanism of the exocrine pancreas to the amount and the type of dietary fat. We review the kinetics of pancreatic adaptation and the mediators of the adaptive response of the pancreas including cellular and molecular mechanisms (modulation of intracellular messengers and gene expression of the different enzymes and secretagogues involved in the adaptation process). At the same time we include our results in this field in dogs and humans.

show abstract

Neurohormonal Aspects of Gallbladder Contractility in Gallstone Disease: The Role of Cholecystokinin

et al. 1990

View full text Add to dashboard Cite

Intracellular Messengers in Stimulus-Secretion Coupling of Pancreatic Acinar Cells

Cited by 5 publications

References 0 publications

Interaction between secretin and nerve‐mediated amylase secretion in the isolated exocrine rat pancreas

Interaction between secretin and nerve‐mediated amylase secretion in the isolated exocrine rat pancreas

Adaptation of the exocrine pancreas to dietary fats

Neurohormonal Aspects of Gallbladder Contractility in Gallstone Disease: The Role of Cholecystokinin

Contact Info

Product

Resources

About