Intracellular Mechanisms Underlying the Suppression of AMPA Responses by trans-ACPD in Cultured Chick Purkinje Neurons

Mori-Okamoto, Junko; Okamoto, Koichi; Tatsuno, Jiro

doi:10.1006/mcne.1993.1047

Cited by 47 publications

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“…Similarly, in multiple systems a developmental increase in neuronal sodium current density causes increasing dependency of action potentials on sodium as well as increasing action potential amplitudes. Simultaneously, developmental increases in the amplitudes of transient potassium currents narrow spike shape (O'Dowd et al ., ; McCobb et al ., ; Mori‐Okamoto et al ., ; Mercer & Hildebrand, ).…”

Section: Discussionmentioning

confidence: 99%

Sequential acquisition of cacophony calcium currents, sodium channels and voltage‐dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron

Ryglewski

Kilo

Duch

2014

Eur J of Neuroscience

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During metamorphosis the CNS undergoes profound changes to accommodate the switch from larval to adult behaviors. In Drosophila and other holometabolous insects, adult neurons differentiate either from respecified larval neurons, newly born neurons, or are born embryonically but remain developmentally arrested until differentiation during pupal life. This study addresses the latter in the identified Drosophila flight motoneuron 5. In situ patch-clamp recordings, intracellular dye fills and immunocytochemistry address the interplay between dendritic shape, excitability and ionic current development. During pupal life, changes in excitability and spike shape correspond to a stereotyped, progressive appearance of voltage-gated ion channels. High-voltage-activated calcium current is the first current to appear at pupal stage P4, prior to the onset of dendrite growth. This is followed by voltage-gated sodium as well as transient potassium channel expression, when first dendrites grow, and sodium-dependent action potentials can be evoked by somatic current injection. Sustained potassium current appears later than transient potassium current. During the early stages of rapid dendritic growth, sodium-dependent action potentials are broadened by a calcium component. Narrowing of spike shape coincides with sequential increases in transient and sustained potassium currents during stages when dendritic growth ceases. Targeted RNAi knockdown of pupal calcium current significantly reduces dendritic growth. These data indicate that the stereotyped sequential acquisition of different voltage-gated ion channels affects spike shape and excitability such that activity-dependent calcium influx serves as a partner of genetic programs during critical stages of motoneuron dendrite growth.

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Section: Discussionmentioning

confidence: 99%

Sequential acquisition of cacophony calcium currents, sodium channels and voltage‐dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron

Ryglewski

Kilo

Duch

2014

Eur J of Neuroscience

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“…However, this kinase was not required for the potentiation of AMPA receptor activity by a specific agonist of mGluR5, suggesting that when mGluR1 and 5 are activated simultaneously the signaling cascade activated by the former type of receptor predominates (73). In contrast with these effects, the group I and II mGluR agonists (1S,3R)-ACPD decreased AMPA responses in cultured chick cerebellar Purkinje neurons, and this effect was antagonized by protein kinase C inhibitors (78). Although the mechanism involved in the depression of AMPA receptor activity was not investigated, it may be related to the effect of group I mGluR in the hippocampus, where these receptors induce the internalization of AMPA receptors by a mechanism dependent on new protein synthesis (79,80).…”

Section: Regulation Of Ampa Receptors By Metabotropic Receptorsmentioning

confidence: 96%

Untitled

Gomes

Correia

Carvalho

et al. 2003

Neurochemical Research

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The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors for the neurotransmitter glutamate are oligomeric structures responsible for most fast excitatory responses in the central nervous system. The activity of AMPA receptors can be directly regulated by protein phosphorylation, which may also affect the interaction with intracellular proteins and, consequently, their recycling and localization to defined postsynaptic sites. This review focuses on recent advances in understanding the dynamic regulation of AMPA receptors, on a short- and long-term basis, and its implications in synaptic plasticity.

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“…Hippocampal slices ↑ LTD Zho et al, 2002; (Mori-Okamoto et al, 1993) mGluR1 Cultured Purkinje neurons ↑ LTD mGluR1 Cerebellar slices ↑ LTD (Aiba et al, 1994;Conquet et al, 1994;Hartell 1994) Dopamine D 1 receptors Dorsal striatum ↑ AMPAR EPSPs (Umemiya and Raymond 1997;Lin et al, 2003) (Yan et al, 1999) (Calabresi et al, 2000Kerr and Wickens 2001) ?Rundown of iontophoretic AMPAR currents ↑ LTP D 2 receptors Dorsal striatum ↓ AMPAR EPSPs ? LTP (Cepeda et al, 1993;Levine et al, 1996) (Trueblood et al, 1996) 2003) .…”

Section: Rat Spinal Dorsal Horn Neuronsmentioning

confidence: 99%

“…Immunohistochemistry experiments showed GluR1, GluR2, GluR2/3, and mGluR1 immunoreactivity in the synaptic zone of dendritic spines at the ganglion cell-Purkinje neuron synapses (Baude et al, , 1994Petralia et al, 1998). Initial studies performed in cultured chick Purkinje neurons and in slices from the rat cerebellum showed that mGluRs inhibit AMPA-mediated responses in Purkinje cells (Ito and Karachot, 1990;Mori-Okamoto et al, 1993). Subsequent studies showed that the induction of LTD at the PFs-Purkinje cell synapses requires activation of mGluR1 (Kano and Kato, 1987;Linden et al, 1991;Aiba et al, 1994;Conquet et al, 1994;Hartell, 1994;Shigemoto et al, 1994), Ca 2þ influx through voltage-gated Ca 2þ channels (Linden et al, 1991;Konnerth et al, 1992) and AMPA receptor activation (Linden et al, 1993).…”

Section: Cerebellar Purkinje Neuronsmentioning

confidence: 99%

Handbook of Neurochemistry and Molecular Neurobiology

2008

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Additionally, the whole set will be available upon completion under The electronic version of the whole set will be available under The print and electronic bundle of the whole set will be available under ISBN: 978-0-387-35478-1 ß 2008 Springer Science+Business Media, LLC.All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC., 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. springer.comPrinted on acid-free paper SPIN: 11416593 2109 -5 4 3 2 1 0 PrefaceThe brain is the organ that collects information from the environment, processes and stores the information, and generates behavior as and when needed. In essence, the brain makes us who we are. For this reason, understanding the biology of brain function is a great challenge and a major goal of modern science. The brain is one of the last great frontiers in science, and the unraveling of its mysteries is comparable in complexity to efforts in space exploration. Therefore, it was not a surprise that the U.S. Congress proclaimed the 1990s the ''Decade of the Brain,'' a movement also introduced by several other countries, thereby giving a chance for neuroscientists to focus on this topic and to have better conditions for their research.A fundamental goal of neuroscience is to understand how neurons generate behavior and the pathophysiology of different mental and neurological diseases. This requires, among other things, information about where these neurons are located, how they are connected, and how they communicate with each other in various physiological and pathophysiological conditions.At the end of the nineteenth century, the great neuroanatomist Santiago Ramon y Cajal recognized that neurons are the individual signaling elements of the brain. In this book, we focus on these nerve cells of the brain and the chemical molecules that allow them to talk to each other. The discovery of intercellular communication through endogenous molecules is a milestone in the history of science. It makes the brain a unique organ.Our aim is to describe recent discoveries about the basic operations of the brain and to provide an introduction to the adaptations for specific types of information processing. For example, at a chemical synapse, the presynaptic terminal liberates a transmitter substance that acts on the postsynaptic process. Thus, a synapse converts a presynaptic electrical signal into a chemical signal and back into a postsynaptic electrical signal.Cur...

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Intracellular Mechanisms Underlying the Suppression of AMPA Responses by trans-ACPD in Cultured Chick Purkinje Neurons

Cited by 47 publications

References 0 publications

Sequential acquisition of cacophony calcium currents, sodium channels and voltage‐dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron

Sequential acquisition of cacophony calcium currents, sodium channels and voltage‐dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron

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Handbook of Neurochemistry and Molecular Neurobiology

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