Intracellular magnesium concentrations and acute anthracycline-induced cardiotoxicity

Sartori, Sergio; Nielsen, Ingolf; Tassinari, Davide; Maestri, A; Abbasciano, Vincenzo

doi:10.1038/bjc.1991.399

Cited by 5 publications

(2 citation statements)

References 12 publications

(9 reference statements)

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“…Decrease in myocardial Mg content has been shown in experimental heart failure induced by rapid ventricular pacing in dogs (Haigney et al 1998), as well as in the biopsies from heart failure patients (Ralston et al 1989). Regarding the anthracycline-induced cardiotoxicity, in a clinical study by Sartori et al (1991), intracellular Mg content decreases paralleled the severity of cardiac disturbances in patients receiving doxorubicin or epirubicin-containing chemotherapy. The mechanism causing this cardiac Mg loss is unknown.…”

Section: Discussionmentioning

confidence: 94%

Myocardial content of selected elements in experimental anthracycline-induced cardiomyopathy in rabbits

et al. 2005

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Cardiotoxicity represents the main drawback of clinical usefulness of anthracycline antineoplastic drugs. In this study, a content of selected elements (Ca, Mg, K, Se, Fe) in the post-mortem removed samples of the myocardial tissue was studied in three groups of rabbits: 1) control group (i.v. saline; n = 10); 2) daunorubicin-receiving animals (DAU; 3 mg/kg, i.v; n = 11); 3) animals receiving cardioprotective iron-chelating agent dexrazoxane (DEX; 60 mg/kg, i.p.; n = 5) prior to DAU. Drugs were administered once weekly for 10 weeks. 5-7 days after the last administration, cardiac left ventricular contractility (dP/dtmax) was significantly decreased in DAU-treated animals (745 +/- 69 versus 1245 +/- 86 kPa/s in the control group; P < 0.05), while in the DEX + DAU group it was insignificantly increased (1411 +/- 77 kPa/s). Of the myocardial elements' content studied, a significant increase in total Ca against control (16.2 +/- 2.4 versus 10.6 +/- 0.9 microg/g of dry tissue; P < 0.05) was determined in the DAU-group, which was accompanied with significant decreases in Mg and K. In the heart tissue of DEX-pretreated animals, no significant changes of elements' content were found as compared to controls, while the Ca content was in these animals significantly lower than in the DAU group (9.1 +/- 0.4 versus 16.2 +/- 2.4 microg/g; P < 0.05). Hence, in this study we show that systolic heart failure induced by chronic DAU administration is primarily accompanied by persistent calcium overload of cardiac tissue and the protective action of DEX is associated with the restoration of normal myocardial Ca content.

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Section: Discussionmentioning

confidence: 94%

Myocardial content of selected elements in experimental anthracycline-induced cardiomyopathy in rabbits

et al. 2005

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“…It seems to be contradictory, based on the fact that lower levels of Mg were associated to cardio toxicity. Nevertheless previous studies about the doxorubicin cardiotoxic effects also reported an increase of Mg levels after chemotherapy administration [41] [42]. Doxorubicin a widely chemo-therapeutic agent, used for BC, and other types of cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

Alterations in Low-Z Elements Distribution in Heart Tissue after Treatments to Breast Cancer Using LEXRF Technique

Mantuano¹,

Barroso²,

Nogueira³

et al. 2016

AJAC

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Data from Global Cancer Statistics show that breast cancer (BC) is the most common type of cancer among women, leading the number of deaths caused by cancer. The developments in diagnosis and treatment techniques for the BC, including chemotherapy and/or radiotherapy, increased the survival rates for this type of cancer. One late complication induced by BC treatment is the cardiotoxicity. This term comprises different cardiotoxic side effects, which include blood pressure alterations, myocardial ischemia, congestive heart failure and other damages. This study aimed to evaluate the cardiac alterations induced by radiotherapy and chemotherapy, simulating a treatment for BC in Wistar rats. It is, therefore, important to understand the mechanisms involved in the cardiotoxicity, in order to prevent women from this late effect, when they undergo BC treatments. The major interests in this work are in Low atomic weight elements as Sodium, because it is strongly related to cardiomyocyte contraction; Magnesium, because it is important in the cardiac metabolism; and Iron, because BC treatment induced cardiotoxicity can be associated to the oxidative stress. Changes that occur in unhealthy tissues in case to cardiovascular damages can be better understood when elemental compounds and structures of healthy tissues are known. Low Energy X-ray Fluorescence (LEXRF) technique was used to obtain elemental maps of low Z-elements providing a semi-quantitative analysis of the tissues evaluated under different conditions. Through the technique LEXRF we obtained elemental and absorption maps. The results showed more damages when associating chemotherapy and radiotherapy in comparison to myocardium healthy. Those images taken together with light microscopy, X-ray absorption and phase How to cite this paper: Mantuano, A., Barroso, R.C., Nogueira, L.P., Colaço, M.V., Mota, C.L., Pickler, A., Braz, D., Salata, C., Ferreira-Machado, S., de Almeida, C.E. and 755contrast images, satisfactorily characterize the cardiac tissue for the first time in the literature, from the structural and morphological points of view. LEXRF was carried out at TwinMic beamline in the ELETTRA Synchrotron Facility, at the beamline TwinMic, in Trieste, Italy.

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Magnesium and neoplasia: From carcinogenesis to tumor growth and progression or treatment

Wolf¹,

Maier²,

Nasulewicz³

et al. 2007

Archives of Biochemistry and Biophysics

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Intracellular magnesium concentrations and acute anthracycline-induced cardiotoxicity

Cited by 5 publications

References 12 publications

Myocardial content of selected elements in experimental anthracycline-induced cardiomyopathy in rabbits

Myocardial content of selected elements in experimental anthracycline-induced cardiomyopathy in rabbits

Alterations in Low-Z Elements Distribution in Heart Tissue after Treatments to Breast Cancer Using LEXRF Technique

Magnesium and neoplasia: From carcinogenesis to tumor growth and progression or treatment

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