Intracellular hyperthermia a biophysical approach to cancer treatment via intracellular temperature and biophysical alterations

Gordon, Ryan R.; Hines, JE; Gordon, David

doi:10.1016/0306-9877(79)90063-x

Cited by 279 publications

(158 citation statements)

References 7 publications

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“…The concept is based on the principle that a magnetic particle can generate heat by hysteresis loss when placed in a high-frequency ($1 MHz) magnetic field (Stauffer et al 1984). Intracellular hyperthermia using dextran nanoparticles dates from 1979 (Gordon et al 1979). The principle of heating with superparamagnetic particles (that show no magnetic hysteresis at low frequencies) by an AC field has been reviewed by Rosensweig (2002): the dissipation results from the orientational relaxation of the particles having thermal fluctuations in a viscous medium (Hergt et al 1998).…”

Section: Hyperthermiamentioning

confidence: 99%

Magnetic bead handling on-chip: new opportunities for analytical applications

Gijs

2004

Microfluid Nanofluid

491

555

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This review describes recent advances in the handling and manipulation of magnetic particles in microfluidic systems. Starting from the properties of magnetic nanoparticles and microparticles, their use in magnetic separation, immuno-assays, magnetic resonance imaging, drug delivery, and hyperthermia is discussed. We then focus on new developments in magnetic manipulation, separation, transport, and detection of magnetic microparticles and nanoparticles in microfluidic systems, pointing out the advantages and prospects of these concepts for future analysis applications.

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Section: Hyperthermiamentioning

confidence: 99%

Magnetic bead handling on-chip: new opportunities for analytical applications

Gijs

2004

Microfluid Nanofluid

491

555

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“…More than 20 years later, Gordon et al used a magnetic fluid ('dextran-magnetites' with a core size of up to 6 nm) for hyperthermia after systemic application [8]. Injection of micro-scaled ferromagnetic particles into renal carcinomas of rabbits and subsequent heating was reported by Rand et al in 1981 [9].…”

Section: Introductionmentioning

confidence: 99%

Clinical applications of magnetic nanoparticles for hyperthermia

Thiesen¹,

Jordan

2008

International Journal of Hyperthermia

719

556

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Magnetic fluids are increasingly used for clinical applications such as drug delivery, magnetic resonance imaging and magnetic fluid hyperthermia. The latter technique that has been developed as a cancer treatment for several decades comprises the injection of magnetic nanoparticles into tumors and their subsequent heating in an alternating magnetic field. Depending on the applied temperature and the duration of heating this treatment either results in direct tumor cell killing or makes the cells more susceptible to concomitant radio-or chemotherapy. Numerous groups are working in this field worldwide, but only one approach has been tested in clinical trials so far. Here, we summarize the clinical data gained in these studies on magnetic fluid induced hyperthermia.

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“…The authors heated up various damaged tissue samples with 20-100 nm size particles of -Fe 2 O 3 exposed to a 1.2 MHz magnetic field. Since then the scientists have been developing numerous methods and schemes using different types of magnetic materials, different field strengths and frequencies of encapsulation and delivery of the www.intechopen.com particles (Mosso et al, 1973, Rand et al, 1976, Gordon et al, 1979, Rand et al, 1981, Borrelli et al, 1984, Hase et al, 1990, Suzuki et al, 1990, Chan et al, 1993, Matsuki et al, 1994, Mitsumori et al, 1994, Suzuki et al, 1995, Moroz et al, 2001, Jones et al, 2002. The hyperthermia procedure involves the dispersion of the magnetic particles throughout the target tissue, followed by applying an AC magnetic field with specific parameters (frequency, strength); the magnetization of the particles is continuously reversed, which translates into a conversion from magnetic to thermal energy and causes the heating of particles.…”

Section: Oxidation Stabilitymentioning

confidence: 99%