Intracellular hydrogelation of macrophage conjugated probiotics for hitchhiking delivery and combined treatment of colitis

Melanin Nanoparticle-Modified Probiotics for Targeted Synergistic Therapy of Ulcerative Colitis

“…Selective accumulation in inflammatory colonic tissue is critical for oral UC therapy. − NIR-II fluorescent imaging at different time points was used to evaluate the accumulation of Lf@MPB in the inflammatory colonic tissues. DSS-induced UC mouse model was established and administrated with Lf@MPB@IR820 and Lf@IR820.…”

Advancements in hydrogel-based drug delivery systems for the treatment of inflammatory bowel disease: a review

“…Oral administration is a conventional route for hydrogel-based DDSs, particularly in the treatment of chronic diseases. 173,174 The advantages of oral drug delivery include easy handling, high patient compliance, and potentially low cost. 175 As depicted in Fig.…”

Advanced Bioinspired Multifunctional Platforms Focusing on Gut Microbiota Regulation

“…This allowed for the maintenance of the intact membrane structure without any loss of membrane proteins or spatial disorder, resulting in improved cytokine neutralization efficiency. 37 Macrophage-derived EVs (MEVs) are a dependable substitute for MM while ensuring optimal biocompatibility and targeting ability. Yan Zhou developed a biomimetic nanoformulation (Pd@M) consisting of cubic palladium (Pd) as the core and MEVs as the shell by modulating the macrophage polarization state by inhibiting glycolysis to treat UC (Figure 7C).…”

“…Wrapping membranes or modifying targeting ligands on the surface of synthetic nanocarriers can create biomimetic nanoparticles. These nanoparticles combine the benefits of synthetic nanomaterials and natural components, allowing for precise and safe drug delivery with superior targeting and adhesion capabilities. , These advantages are typically beyond reach in conventional nano designs. The gut is a major site for food digestion and absorption.…”