Advancements in hydrogel-based drug delivery systems for the treatment of inflammatory bowel disease: a review

Liu, Ye; Huang, Jinjian; Li, Sicheng; Li, Ze; Chen, Canwen; Qu, Guiwen; Chen, Kang; Teng, Yitian; Ma, Rui; Wu, Xiuwen; Ren, Jianan

doi:10.1039/d3bm01645e

Cited by 9 publications

(2 citation statements)

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“…6,7 Another formulation used for colon drug delivery is suppositories, but administering this formulation is painful and lacks patient compliance. 8 Therefore, modifying oral formulations is crucial for developing successful colon-targeted drug delivery systems. These modifications aim to enhance drug delivery to the colon, improve formulation efficiency, reduce drug doses, and, importantly, minimize side effects.…”

Section: Introductionmentioning

confidence: 99%

“…The oral route is the most conventional and widely accepted route for colon drug delivery, offering advantages such as dose flexibility, noninvasiveness, patient acceptance, and self-administration . However, its disadvantages, such as lower drug absorption, drug degradation in the upper GIT, and nonspecific distribution, can limit the efficiency of formulations, resulting in reduced drug delivery to the colon and necessitating increased drug doses, leading to elevated side effects. , Another formulation used for colon drug delivery is suppositories, but administering this formulation is painful and lacks patient compliance . Therefore, modifying oral formulations is crucial for developing successful colon-targeted drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

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pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

Kumawat,

Karmakar,

Ghoroi

2024

ACS Appl. Nano Mater.

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In the realm of colon-based drug delivery, developing a pHresponsive nanocarrier that exhibits significant intrinsic reactive oxygen species (ROS) scavenging activity holds great promise. To address this, a nanogel (NG) is synthesized using itaconic acid (IAc) and acrylamide (AAm) monomers in a molar ratio of 1:4 via free radical polymerization. The spherical NG of size 190 ± 15 nm is confirmed by using field emission scanning electron microscopy (FESEM). Dynamic light scattering (DLS) characterization reveals a hydrodynamic diameter and zeta potential of 271 ± 23 nm and −6.9 ± 2.3 mV, respectively. FTIR, XPS, and NMR analyses confirm the presence of multiple functionalities on the NG. Significant improvement in swelling (10 times) at colonic pH (pH 7.4) in contrast to gastric pH (pH 1.2) ensures the pH-responsive behavior of a NG along with five times higher ROS scavenging activity compared to control. As a model drug, doxorubicin (DOX) is employed to investigate release properties and cellular uptake. The NG exhibited drug loading capacity and efficiency of 26 ± 1.2% and 90 ± 1.3%, respectively, with a three times higher DOX release at pH 7.4 than at pH 1.2. Rheology data reveal the superior structural integrity of the doxorubicin loaded nanogel (DNG) compared to the NG. The biocompatibility of the NG is confirmed through MTT, the hemolysis assay, and cell uptake assays on HCT-116 colon cancer cells. The cellular uptake studies have indicated NG-mediated drug release in the colon microenvironment with subsequent passive diffusion of DOX into cells. These findings underscore the capability of the synthesized NG as a vehicle for oral drug delivery to the colon.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

Kumawat,

Karmakar,

Ghoroi

2024

ACS Appl. Nano Mater.

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Multifaceted Hydrogel Scaffolds: Bridging the Gap between Biomedical Needs and Environmental Sustainability

Mamidi,

De Silva,

Vacas

et al. 2024

Adv Healthcare Materials

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Hydrogels are dynamically evolving 3D networks composed of hydrophilic polymer scaffolds with significant applications in the healthcare and environmental sectors. Notably, protein‐based hydrogels mimic the extracellular matrix, promoting cell adhesion. Further enhancing cell proliferation within these scaffolds are matrix‐metalloproteinase‐triggered amino acid motifs. Integration of cell‐friendly modules like peptides and proteins expands hydrogel functionality. These exceptional properties position hydrogels for diverse applications, including biomedicine, biosensors, environmental remediation, and the food industry. Despite significant progress, there is ongoing research to optimize hydrogels for biomedical and environmental applications further. Engineering novel hydrogels with favorable characteristics are crucial for regulating tissue architecture and facilitating ecological remediation. This review explores the synthesis, physicochemical properties, and biological implications of various hydrogel types and their extensive applications in biomedicine and environmental sectors. It elaborates on their potential applications, bridging the gap between advancements in the healthcare sector and solutions for environmental issues.This article is protected by copyright. All rights reserved

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Matrix metalloproteinase-responsive hydrogels with tunable retention for on-demand therapy of inflammatory bowel disease

Xie,

Wang,

Deng

et al. 2024

Acta Biomaterialia

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Advancements in hydrogel-based drug delivery systems for the treatment of inflammatory bowel disease: a review

Abstract: Inflammatory bowel disease (IBD) is a chronic disorder that affects millions of individuals worldwide. However, current drug therapies for IBD are plagued by significant side effects, low efficacy, and poor...

Cited by 9 publications

References 261 publications

pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

pH-Responsive, Reactive Oxygen Species Scavenging and Highly Swellable Nanogel for Colon-Targeted Oral Drug Delivery

Multifaceted Hydrogel Scaffolds: Bridging the Gap between Biomedical Needs and Environmental Sustainability

Matrix metalloproteinase-responsive hydrogels with tunable retention for on-demand therapy of inflammatory bowel disease

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