Intracellular Enzyme-Responsive Profluorophore and Prodrug Nanoparticles for Tumor-Specific Imaging and Precise Chemotherapy

Pei, Qing; Lu, Shaojin; Zhou, Junli; Jiang, Bowen; Li, Chaonan; Xie, Zhigang; Jing, Xiabin

doi:10.1021/acsami.1c19058

Cited by 14 publications

(8 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Enzymes have been used extensively as prodrug release triggers for stimulus-sensitive materials due to their high selectivity toward tumor cells ( Pei et al, 2021 ; Zeng et al, 2021 ). For example, cathepsin B is overexpressed in the cells of various types of tumors, which acts as a lysosomal cysteine protease and can cleave proteins containing an oligopeptide glycylphenylalanylleucylglycine (Gly-Phe-Leu-Gly, GFLG) linker ( Cheng et al, 2020 ; Jin et al, 2020 ).…”

Section: Enzyme-sensitive Polymer-ptx Prodrugmentioning

confidence: 99%

Recent Advances in Stimuli-Sensitive Amphiphilic Polymer-Paclitaxel Prodrugs

Zhou

Wen

Wang

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Paclitaxel (PTX) is a broad-spectrum chemotherapy drug employed in the treatment of a variety of tumors. However, the clinical applications of PTX are limited by its poor water solubility. Adjuvants are widely used to overcome this issue. However, these adjuvants often have side effects and poor biodistribution. The smart drug delivery system is a promising strategy for the improvement of solubility, permeability, and stability of drugs, and can promote sustained controlled release, increasing therapeutic efficacy and reducing side effects. Polymeric prodrugs show great advantages for drug delivery due to their high drug loading and stability. There has been some groundbreaking work in the development of PTX-based stimulus-sensitive polymeric prodrug micelles, which is summarized in this study. We consider these in terms of the four main types of stimulus (pH, reduction, enzyme, and reactive oxygen species (ROS)). The design, synthesis, and biomedical applications of stimulus-responsive polymeric prodrugs of PTX are reviewed, and the current research results and future directions of the field are summarized.

show abstract

Section: Enzyme-sensitive Polymer-ptx Prodrugmentioning

confidence: 99%

Recent Advances in Stimuli-Sensitive Amphiphilic Polymer-Paclitaxel Prodrugs

Zhou

Wen

Wang

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Hypoxia comes from the inadequate supply of oxygen in tissues and is implicated in some cancers that disturb the microcirculation, such as the unbalanced redox-stress and the slightly acidic tumor microenvironment (pH 6.5–7.0), , and it is closely related to various enzymes expression level in tumors. , An urgent demand that can potentially identify the characteristics of tumors, such as the degree of hypoxia, slightly acidic microenvironments, or the abnormal expression of hypoxia-related enzymes, is critical in cancer detection, prediction, and, particularly, treatment. Among these, considerable attention has been given to NTR, which is a flavin enzyme overexpression in hypoxia tumor cells, , as well as its related fluorescent probes.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Host–Guest Strategy for the Accelerating Detection of Nitroreductase

Zhang

Jiao

Yang

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Identifying nitroreductase (NTR) with fluorescent techniques has become a research hotspot, due to its good sensitivity and selectivity toward the early-stage cancer diagnosis and monitoring. Herein, a host−guest reporter (NAQA⊂Zn-MPPB) is successfully achieved by encapsulating the NTR probe NAQA into a new NADH-functioned metal−organic cage Zn-MPPB, which makes the reporter for ultrafast detection of NTR within dozens of seconds in solution. The host−guest strategy fuses the Zn-MPPB and NAQA to form a pseudomolecule material, which changes the reaction process of NTR and NAQA from a double substrates mechanism to a single substrate one, and accelerates the reduction efficiency of NAQA. This advantage make the new host−guest reporter exhibit a linear relationship between emission changes and NTR concentration, and it shows better sensitively toward NTR than that of NAQA. Additionally, the positively charged water-soluble metal−organic cage can encapsulate NAQA in the cavity, promote it to dissolve in an aqueous environment, and facilitate their accumulation into tumor cells. As expected, such host−guest reporter displays a fast and high efficiently imaging capability toward NTR in tumor cells and tumor-bearing mice, and flow cytometry assay is conducted to corroborate the capability as well, implying the considerably potential of host−guest strategy for early tumor diagnosis and treatment.

show abstract

“…Implanting tumor microenvironment responsive repertoire is an effective strategy to realize precise treatment and simultaneously alleviate off‐target toxicity. [ 14 ] Our group has reported a series of redox‐, [ 5c,15 ] hypoxia‐, [ 16 ] and enzyme [ 17 ] ‐activatable PTX prodrug for improved chemotherapy. The construction of a PTX prodrug nanoparticle with the help of ICG would improve the drug delivery efficacy, chemotherapy selectivity, and NIR imaging of cancer.…”

Section: Introductionmentioning

confidence: 99%

Indocyanine green potentiated paclitaxel nanoprodrugs for imaging and chemotherapy

Xiang

Feng

et al. 2022

Exploration

Self Cite

View full text Add to dashboard Cite

Self-assembled prodrug nanoparticles with tumor-responsive capacity have great potential in tumor visualization and treatment. However, the nanoparticle formulas usually contain multiple components, especially polymeric materials, which result in various potential issues. Herein, we report an indocyanine green (ICG)-driven assembly of paclitaxel prodrugs integrating near-infrared fluorescence imaging and tumor-specific chemotherapy. By feat of the hydrophilic merit of ICG, paclitaxel dimer could form more uniformly monodispersed nanoparticles. This two-in-one strategy reinforces the complementary advantages, resulting in superior assembly behavior, robust colloidal stability, enhanced tumor accumulation as well as desirable near-infrared imaging and in vivo feedback of chemotherapy. The in vivo experiments validated the prodrug activation at tumor sites as evidenced by enhanced fluorescence intensity, potent tumor growth suppression, and reduced systemic toxicity compared with commercial Taxol. The universality of ICG potentiated strategy toward photosensitizers and fluorescence dyes was confirmed. This presentation provides deep insight into the feasibility of constructing clinical-close alternatives for improving antitumor efficacy.

show abstract

Intracellular Enzyme-Responsive Profluorophore and Prodrug Nanoparticles for Tumor-Specific Imaging and Precise Chemotherapy

Cited by 14 publications

References 65 publications

Recent Advances in Stimuli-Sensitive Amphiphilic Polymer-Paclitaxel Prodrugs

Recent Advances in Stimuli-Sensitive Amphiphilic Polymer-Paclitaxel Prodrugs

Supramolecular Host–Guest Strategy for the Accelerating Detection of Nitroreductase

Indocyanine green potentiated paclitaxel nanoprodrugs for imaging and chemotherapy

Contact Info

Product

Resources

About