Indocyanine green potentiated paclitaxel nanoprodrugs for imaging and chemotherapy

Abstract

Self-assembled prodrug nanoparticles with tumor-responsive capacity have great potential in tumor visualization and treatment. However, the nanoparticle formulas usually contain multiple components, especially polymeric materials, which result in various potential issues. Herein, we report an indocyanine green (ICG)-driven assembly of paclitaxel prodrugs integrating near-infrared fluorescence imaging and tumor-specific chemotherapy. By feat of the hydrophilic merit of ICG, paclitaxel dimer could form more uniformly monodispersed nanoparticles. This two-in-one strategy reinforces the complementary advantages, resulting in superior assembly behavior, robust colloidal stability, enhanced tumor accumulation as well as desirable near-infrared imaging and in vivo feedback of chemotherapy. The in vivo experiments validated the prodrug activation at tumor sites as evidenced by enhanced fluorescence intensity, potent tumor growth suppression, and reduced systemic toxicity compared with commercial Taxol. The universality of ICG potentiated strategy toward photosensitizers and fluorescence dyes was confirmed. This presentation provides deep insight into the feasibility of constructing clinical-close alternatives for improving antitumor efficacy.

TME-triggered copper-coordinated engineered programmable nanogenerators for on-demand cascade-amplifying oxidative stress

“…Therefore, our results combined with previous studies have evidenced that ECH could be co-assembled by the sulfonic acid group in EB and carbonyl group in HND interacting with Cu II by dynamic coordination bonds. 37…”

“…Therefore, our results combined with previous studies have evidenced that ECH could be co-assembled by the sulfonic acid group in EB and carbonyl group in HND interacting with Cu II by dynamic coordination bonds. 37 The HRTEM image can obtain the lattice stripe image (reflecting the crystal plane spacing information) and SEAD image can distinguish between single crystals and polycrystals. Therefore, to further explore the structure of ECH, XRD, HRTEM, and SAED were also performed.…”

Recent Progress of Paclitaxel Delivery Systems: Covalent and Noncovalent Approaches

“…Based on the esterification of C2'-OH group, ROS-responsive PTX dimer were developed with alkyl mono-sulfide/selenide/telluride, [147,148] and disulfide/diselenide/ditelluride spacers. [149][150][151] Crosslinked PTX dimers form over 100 nm vesicles but additive molecules can further extend the stability and functionality, such as indocyanine green, [151] surfactant pluronic F-127, [152] DSPE-PEG, human serum albumin, [150] and 𝛽-CD. [153] Moreover, Xie group also employed special crosslinkers such as hypoxia and lightresponsive azobenzene, [152] or H 2 O 2 activated 17-fluorinated ethanol [154] to enrich PTX delivery systems.…”

Regulation of Interstitial Fluid Pressure for Improved Intratumor Drug Permeability and Nanozyme-Enhanced Chemocatalytic Therapy

“…In recent years, nanomedicines have been widely used in the treatment of tumors. − However, due to the low amount of drug accumulation in tumors, , it is difficult to completely remove the deep tumor cells, which is liable to induce tumor recurrence and metastasis . The research found that the continuous infusion of blood enters the tumor site, but because there is no lymphatic vessel to make the interstitial fluid return to the blood system, resulting in substantial interstitial fluid retention and the tumor interstitial fluid pressure (TIFP) abnormally increases.…”