Intracellular Binding and Transport of Hormones and Xenobiotics by Glutathiones-Transferases

Glutathione S-transferase expression in the human testis and testicular germ cell neoplasia

“…The function of GSTs in the Leydig cell has not been defined. They have a role in steroid transport and isomerisation (Listowsky et al, 1988) and this may also be of importance in the Sertoli cell. GST Alpha is present in the corresponding cell in human ovary, the enzymatically active stromal cell (EASC) (Rahilly et al, 1991).…”

Structure of human glutathione S-transferase class Mu genes

“…The soluble glutathione S-transferases (GSTs; EC 2.5.1.18) are a group of dimeric isoenzymes exhibiting catalytic activities that include the conjugation of GSH with genotoxic and cytotoxic electrophiles, the biosynthesis of physiologically active compounds such as leukotriene C4 and prostaglandin E2 and the binding of hydrophobic compounds such as steroid hormones (Ketterer et al, 1986;Listowsky et al, 1988). The subunits of mammalian GSTs fall into three classes, Alpha, Mu and Pi, according to their primary structures (Mannervik et al, 1985;Pickett, 1987), and their gene structure is conserved between rat (Telakowski-Hopkins et al, 1986) and mouse (Daniel et al, 1987) for Alpha class genes and between rat (Okuda et al, 1987) and human (Cowell et al, 1988;Morrow et al, 1989) for the Pi class genes.…”

Molecular docking of Anopheles gambiae and Aedes aegypti glutathione S-transferases epsilon 2 (GSTE2) against usnic acid: an evidence of glutathione conjugation

“…The GSTs displays multispecificity for substrate metabolism, involved in the catalysis of endogenous and xenobiotic compounds (Che-mendoza 2009). GSTs also function as non-enzymatic binding proteins (known as ligandins) participating in the intracellular transport (Listowsky et al 1988) and signaling processes (Adler et al 1999;Cho et al 2001). This diversity of enzymatic and nonenzymatic functions is explained by the genetic capacity to encode different GST isoforms by the organisms (Che-mendoza 2009).…”