Intracellular Bacteria in the Pathogenesis of Escherichia coli Urinary Tract Infection in Children

Robino, Luciana; Scavone, Paola; Araújo, Lucía; Algorta, Gabriela; Zunino, Pablo; Pírez, María Catalina; Vignoli, Rafael

doi:10.1093/cid/ciu634

Cited by 93 publications

(88 citation statements)

References 30 publications

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“…After their maturation, bacteria disperse from the IBC to invade other cells, where the IBC cycle is repeated 38–40 . IBC formation is a common mechanism for clinical UPEC isolates and has been observed in multiple mouse backgrounds and also in exfoliated uroepithelial cells in the urine of patients with acute UTIs but not in the cells in urine from healthy controls 41,42 . The process of invasion and IBC formation provides UPEC with the ability to survive stringent bottlenecks in the urinary tract, including TLR4-mediated expulsion, umbrella cell exfoliation, ascension to the kidneys, urination and inflammation 7,43 .…”

Section: Adherence and Colonizationmentioning

confidence: 99%

Urinary tract infections: epidemiology, mechanisms of infection and treatment options

et al. 2015

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Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. High recurrence rates and increasing antimicrobial resistance among uropathogens threaten to greatly increase the economic burden of these infections. In this Review, we discuss how basic science studies are elucidating the molecular details of the crosstalk that occurs at the host–pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs. We also describe current efforts to translate this knowledge into new clinical treatments for UTIs.

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Section: Adherence and Colonizationmentioning

confidence: 99%

Urinary tract infections: epidemiology, mechanisms of infection and treatment options

et al. 2015

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“…One study that evaluated children with E coli cystitis found intracellular bacterial in 36.8% of the patients. 38 In renal transplant recipients screened for UTIs, IBCs were visualized in 23 of 53 patients (44%), with only 1 patient deemed to have a UTI by standard bacterial culture. 39 Another study looked at women with LUTS compared with asymptomatic controls and found 75% of the LUTS patients had evidence of IBCs compared with 17% of the controls.…”

Section: Evidence For Urothelial Invasion In Humansmentioning

confidence: 98%

Intracellular Bacterial Communities: A Potential Etiology for Chronic Lower Urinary Tract Symptoms

Scott

Haake

Churchill

et al. 2015

Urology

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Patients with persistent lower urinary tract symptoms and negative urine cultures are often difficult to treat. Infection may go undetected in these patients because the concentrations of bacteria in their urine are beneath the threshold of standard urine culture techniques. Empiric treatment may result in temporary relief, followed by recurrent symptoms. Occult and recurrent urinary tract infection may be due to both invasion of the bladder wall by uropathogenic Escherichia coli and the formation of biofilm-like intracellular bacterial communities. This review examines emerging evidence for a role of intracellular bacterial communities in human infection.

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“…As part of the host response, the superficial facet cells are largely exfoliated [20], liberating IBCs into the urine and ridding the body of thousands of bacteria. Shed IBC-containing cells are observed in the urine of infected women and children, supporting their clinical relevance [21, 22]. After 16–24 h in murine UTI models, a subset of UPEC in remaining IBCs adopt a neutrophil-resistant, filamentous morphology and escape the IBCs, subsequently re-invading naïve bladder epithelial cells [23].…”

Section: Molecular Pathogenesis Of Utimentioning

confidence: 99%

Urinary Tract Infection: Pathogenesis and Outlook

McLellan

Hunstad

2016

Trends in Molecular Medicine

266

206

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The clinical syndromes comprising urinary tract infection (UTI) continue to exert significant impact on millions of patients worldwide, most of whom are otherwise healthy women. Antibiotic therapy for acute cystitis does not prevent recurrences, which plague up to one fourth of women after an initial UTI. Rising antimicrobial resistance among uropathogenic bacteria further complicates therapeutic decisions, necessitating new approaches based on fundamental biological investigation. In this review, we highlight contemporary advances in the field of UTI pathogenesis and how these might inform both our clinical perspective and future scientific priorities.

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Intracellular Bacteria in the Pathogenesis of Escherichia coli Urinary Tract Infection in Children

Abstract: IBCs/IIB could explain a high proportion of children with recurrent UTI.

Cited by 93 publications

References 30 publications

Urinary tract infections: epidemiology, mechanisms of infection and treatment options

Urinary tract infections: epidemiology, mechanisms of infection and treatment options

Intracellular Bacterial Communities: A Potential Etiology for Chronic Lower Urinary Tract Symptoms

Urinary Tract Infection: Pathogenesis and Outlook

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