Intracardiac Thrombus in a Young Man: Don't Forget Behçet's Disease!

Hammami, R.; Abid, Leïla; Frikha, F.; Marzouk, S.; Tounsi, A.; Frikha, Zied; Hentati, Mourad; Bahloul, Z.; Kammoun, S.

doi:10.2169/internalmedicine.51.7640

Cited by 15 publications

(19 citation statements)

References 13 publications

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“…Most of the patients are young males and are from the Mediterranean and the Middle East. Though ICT is usually located in the right side of the heart, mainly the right ventricle, thromboses involving both ventricles or limited only to the left ventricle have been also described [10–14]. In two of our patients, ICT was located in the right side of the heart, and one had thrombus in his left ventricle.…”

Section: Discussionmentioning

confidence: 64%

“…Most cases of BD complicating ICT showed complete resolution or decreased in size with systemic corticosteroid and intravenous cyclophosphamide along with anticoagulants [5, 13, 14, 20, 26, 37, 38]. Ahn et al showed that there were no significant differences in the recurrence rate of thrombosis between immunosuppressive therapy and those combined with anticoagulants therapy [39].…”

Section: Discussionmentioning

confidence: 99%

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Behçet’s Disease and Intracardiac Thrombosis: A Report of Three Cases

Düzgün

Küçükşahin

Atasoy

et al. 2013

Case Reports in Rheumatology

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We present three patients with Behçet's disease associated with intracardiac thrombus and pulmonary vascular involvement. One of these patients had also Budd-Chiari syndrome. All patients were treated with corticosteroid plus monthly intravenous cyclophosphamide as first line treatment and with no recurrences. Immunosuppressive therapy was successful in the treatment of intracardiac thrombus and also in the regression of pulmonary vascular thromboses in these patients. Intracardiac thrombus in Behçet's disease is rarely seen. Behçet's disease should be remembered in the differential diagnosis of the patients with intracardiac mass, especially in patients from the Mediterranean and Middle East populations.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Behçet’s Disease and Intracardiac Thrombosis: A Report of Three Cases

Düzgün

Küçükşahin

Atasoy

et al. 2013

Case Reports in Rheumatology

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show abstract

“…6 Finally, intracardiac thrombosis with pulmonary embolism is described in Bechet's disease and in heparin-induced thrombocytopenia. 7,8 The differential diagnosis of right atrial mass includes vegetation, tumor and thrombus. 9,10 The most common primary tumor is the myxoma and fifteen percent of them arise in the right atrium and clinically both myxoma and thrombi can present with a pulmonary embolism.…”

Section: Discussionmentioning

confidence: 99%

Right Atrial Thrombus Mimicking Myxoma with Subclinical Pulmonary Embolism

2013

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Introduction:Non-valvular atrial fibrillation is a common problem in the elderly, occurring in 2% to 4% of the population > 60 years of age and it is one of the most common causes of embolic systemic events.We report a case of intracardiac thrombosis mimicking myxoma as a complication of atrial fibrillation associated with a prothrombotic state. Case Report:A 60 year old patient was presented with a right atrial mass and a 3 vessel coronary artery disease. The patient had been sufferring from persistent atrial fibrillation. In the past he had a transitory ischemic attack and a lower leg embolism and also he did not receive any anticoagulation therapy.He underwent coronary angiography which showed 3 vessels coronary artery disease. Transthoracic echocardiogram showed a freefloating right atrial mass of size 7.0 x1.1 cm with a highly embolic potential suggesting myxoma or thrombus and is shown in figure 1.Patient underwent an emergency surgery. After institution of the cardiopulmonary bypass he underwent surgical exploration of the right heart chambers and pulmonary arteries with pulmonary embolectomy. No thrombi were found in the right atrium and ventricle but were found in the main, right and left pulmonary artery. He underwent a left internal thoracic artery by-pass graft to left anterior descending artery and a great saphenous vein by-pass graft to the marginal branch. The postoperative course was uneventful. The pulmonary embolism was subclinical. Gross examination of the operative specimen showed pieces of fresh thrombi which were confirmed later also by a histologic examination, and are shown in figure 2. Right Atrial Thrombus Mimicking Myxoma with Subclinical Pulmonary EmbolismA search for a hypercoagulable state revealed normal thrombin, prothrombin and partial thromboplastin times, normal antitrhombin III, protein C and S and homocystein levels. Screening for anticardiolipin antibodies and lupus anticoagulant were negative. Genetic analysis showed heterozygous mutations of FXII

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“…Behçet's disease is a chronic, inflammatory disorder of unknown etiology which is described by Turkish dermatologist Hulusi Behçet [1, 2]. Recurrent oral aphthae, which are essential sign, genital ulcers, and ocular inflammation are the cornerstones of Behçet's manifestation [1, 3].…”

Section: Introductionmentioning

confidence: 99%

“…Recurrent oral aphthae, which are essential sign, genital ulcers, and ocular inflammation are the cornerstones of Behçet's manifestation [1, 3]. It affects mainly young adults, M/F = 2–5/1, with a geographical distribution from the Mediterranean countries to far east [2, 3].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Nodules as an Initial Manifestation of Behçet’s Disease

Malekmohammad

Emamifar

2014

Case Reports in Rheumatology

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Behçet's disease (BD) is a systemic vasculopathy, characterized by recurrent oral aphthae, genital ulcers, uveitis, and skin lesions. Although vascular involvement, including venous and arteries of any size, is a usual manifestation, cases with pulmonary thrombosis as the initial symptom are not common in the absence of pulmonary artery aneurysm (PAA). This report describes a 36-year-old man with recurrent fever, nonmassive hemoptysis, and persistent cough with lung nodules in CT scan who had undergone open lung biopsy. On the basis of morphological findings, BD was suggested and more precise evaluation confirmed the diagnosis.

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Intracardiac Thrombus in a Young Man: Don't Forget Behçet's Disease!

Cited by 15 publications

References 13 publications

Behçet’s Disease and Intracardiac Thrombosis: A Report of Three Cases

Behçet’s Disease and Intracardiac Thrombosis: A Report of Three Cases

Right Atrial Thrombus Mimicking Myxoma with Subclinical Pulmonary Embolism

Pulmonary Nodules as an Initial Manifestation of Behçet’s Disease

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