“…Intraoperative FS, to its advantage, assesses all high-risk criteria (including tumor size, histological subtype, histological grade, and depth of MI) with reasonably high diagnostic performance. 20 Researchers from the Mayo Clinic, where systematic use of FS in the intraoperative setting was pioneered, reported in a prospective analysis discrepancy rates as low as 7% between the FS and permanent section results of 784 patients with EC. 21 This discordance rate in histological subtype, histological grade, and MI translated into a clinically significant change in only 1.3% of patients, illustrating that FS may be the most reliable technique for intraoperative decision-making in institutions with a robust intraoperative consultation system.…”