Intra-Articular Injection of Y-90 Resin Colloid in the Treatment of Rheumatoid Knee Joint Effusions

Oka, Martti; Rekonen, A; Ruotsi, Ahti; Seppälä, Olavi

doi:10.3109/rhe1.1971.17.issue-1-4.20

Cited by 52 publications

(14 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S ynovectomy by radioisotopes has been practised in clinical rheumatology in several countries for almost 50 years, [1][2][3][4] although randomised clinical trials have never proved it to be effective. 5 The most common target is the chronically inflamed knee joint of a patient with rheumatoid arthritis (RA).…”

mentioning

confidence: 99%

Does yttrium radiosynovectomy increase the risk of cancer in patients with rheumatoid arthritis?

Vuorela

Sokka²,

Pukkala³

et al. 2003

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

mentioning

confidence: 99%

Does yttrium radiosynovectomy increase the risk of cancer in patients with rheumatoid arthritis?

Vuorela

Sokka²,

Pukkala³

et al. 2003

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

“…First, immobilisation of a joint for 3 or so days after in the knee were injection has been shown to markedly reduce extra-)xide and silicate articular spread (Oka, et al, 1971;Gumpel et al, oride were used 1973b;Williams et al, 1976). A second important lamed knee was factor has been thought to be the degree of inflamtmed knee.…”

Section: Discussionmentioning

confidence: 99%

Intra-articular yttrium 90 in rabbits. Comparison of behaviour of various radiocolloids in rabbits and in man.

Gumpel¹

1978

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

SUMMARY Comparative studies of the retention of various yttrium 90 radiocolloids and of noncolloidal yttrium 90 chloride were performed in rabbits with arthritis induced in one knee. Two colloids, the citrate and resin forms, showed a statistically significant difference in retention between inflamed and normal knees, isotope being retained better in the normal knee. Marked djlerences were found in the handling of the various yttrium preparations in rabbits compared with previously reported results in man. These al., 1973a;Bayly et al., 1973). These initial experiments were extended to see whether more could be learnt about the role of particle size and colloidal form in the handling of radiocolloids by the synovium.Marked differences in the handling of the various colloids were found between rabbits and man. An interesting difference between normal and inflamed knees in rabbits was noted in terms of retention of two of the four radiocolloids used. Materials and methodsCertain characteristics of the radiocolloids are shown in the Table. A part of routine batches of 90Y citrate, ferric hydroxide, and silicate ordered for human use was used in rabbits. 90Y resin colloid is no longer manufactured and a special consignment was supplied for this experiment. Additionally, 90Y chloride, the raw material from which some of these colloids are made, was also used.Accepted for publication July 21, 1977 A Dumonde-Glynn form of chronic synovitis was induced in the right knee of each rabbit by intraarticular injection of gammaglobulin after sensitisation with gammaglobulin. Rabbits were immunised in batches of 6 and then challenged so that animals of one batch could be used for more than one radiocolloid. 100 ,uCi 90Y was injected into each knee of 3 rabbits at one time; one rabbit would be sacrificed at intervals of 24 hours, 48 hours, and 16&6hours. Both knees, regional lymph nodes, and liver were separately removed and counted. Immediately after counting, some synovium was processed for autoradiography.The 90Y content (Ti = 64 hours; maximum beta energy = 2.27 MeV) of each sample was determined by measurement of the bremsstrahlung using two

show abstract

“…Only body compartments capable of retaining particulate material are suitable for such radiotherapy. Examples include the peritoneal cavity and the synovia of joints [1][2][3][4][5]. Radiotherapy of tumours in the liver has been performed by selective injection into a hepatic artery of radioactive particles [6][7][8][9][10][11] or radioactive oil [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Localized internal radiotherapy with 90Y particles embedded in a new thermosetting alginate gel: A feasibility study in pigs

Holte¹,

Skretting²,

Bach‐Gansmo³

et al. 2006

Nuclear Medicine Communications

View full text Add to dashboard Cite

show abstract

Intra-Articular Injection of Y-90 Resin Colloid in the Treatment of Rheumatoid Knee Joint Effusions

Cited by 52 publications

References 11 publications

Does yttrium radiosynovectomy increase the risk of cancer in patients with rheumatoid arthritis?

Does yttrium radiosynovectomy increase the risk of cancer in patients with rheumatoid arthritis?

Intra-articular yttrium 90 in rabbits. Comparison of behaviour of various radiocolloids in rabbits and in man.

Localized internal radiotherapy with 90Y particles embedded in a new thermosetting alginate gel: A feasibility study in pigs

Contact Info

Product

Resources

About