Does yttrium radiosynovectomy increase the risk of cancer in patients with rheumatoid arthritis?

Radionuclide Therapy of Inflammatory Joint Diseases (Radiation Synovectomy, Radiosynoviorthesis)

“…In a 7-year study of 1,228 hospital patients (143 received 90 Y-RSO, 1,085 did not), it was found that those having received RSO had a lower rate of malignancies than those who got no RSO (Vuorela et al 2003). In the author's own experience with RSO since 1972-in the last decade with about 6,000 RSO per year-no one case of potentially RSOinduced malignancy was brought to his attention.…”

“…For the patient: Very late radiation induced stochastic hazards have not been observed (Vuorela et al 2003). In 186 Re RSO, the effective dose to the whole body is Fig.…”

Radiosynoviorthesis in Therapy for Inflammatory Joint Disorders

“…Анализ крови после проведения РСО не выявил наличия статистически значимого повы-шения хромосомных аберраций в лимфоцитах, являю-щихся признаком значительной лучевой нагрузки на сис-тему крови [11]. При проведении РСО с применением 90 Y у больных РА не было выявлено повышения риска разви-тия злокачественных новообразований в сравнении с па-циентами, получившими только медикаментозное лече-ние [12]. В рамках большого канадского исследования изучался риск развития рака более чем у 2400 пациентов, подвергнутых РСО.…”

Synovectomy with 153Samarium Hydroxyapatite in Haemophilic Arthropathy

“…It is important to note that this irradiation is smaller than in diagnosis by conventional bone scintigraphy or whole-body scanning with 67Ga. Considering the local efect at joint level, several studies with long follow-up times have shown no occurrence of tumours [14,26,27], indicating that this possibility has not yet been characterised.…”