Intra-articular injection of indomethacin–methotrexate <i>in situ</i> hydrogel for the synergistic treatment of rheumatoid arthritis

Yin, Na; Guo, Xueting; Sun, Rong; Liu, Hongbing; Tang, Lihua; Gou, Jingxin; Yin, Tian; He, Haibing; Tang, Xing

doi:10.1039/c9tb01795j

Cited by 51 publications

(33 citation statements)

References 27 publications

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“…In addition, the authors assessed the formulation toxicity, liver and kidney function of treated rats and found that the drug-loaded hydrogel did not appear to have side effects on liver or kidney function. Overall, this work demonstrated the synergistic effect of indomethacin and methotrexate loaded in D-NGel, effectively improving the rheumatoid arthritis conditions by releasing these drugs in a controlled manner into the joint tissue(98).Other researchers, Lu et al (2013) (97), evaluated the effect of the hydrogel containing hyaluronic acid and doxycycline (HA-DOX hydrogel) through intra-articular injections using osteoarthritis rabbit model. The authors hypothesised that combining HA and doxycycline in the hydrogel may provide a synergistic effect through the anti-inflammatory and analgesic effect of doxycycline, hyaluronic acid and the lubricant effect of the hydrogel.…”

mentioning

confidence: 72%

Polymer colloids as drug delivery systems for the treatment of arthritis

Saeedi

Alotaibi

Prokopovich

2020

Advances in Colloid and Interface Science

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The most common types of arthritis are osteoarthritis (OA) and rheumatoid arthritis (RA) which are themain causes of disability and pain among older people. Current treatment of arthritis mainly consists of oral and intra-articular medications. Despite the efficacy of the intraarticular injections over the oral treatment, it is still limited by the rapid clearance of the injected drug. Therefore, a rational design of drug delivery systems (DDSs) able to delivery drugs in controlled manner and for required period of time to the arthritis joint is a key in developing safe and effective formulations for OA and RA. In this paper various colloidal systems like nanoparticles, liposomes, cationic carriers, hydrogels, and emulsion-based carriers were presented and discussed in light of their use and efficacy as delivery systems to transport therapeutics for arthritis treatment. Factors influencing the delivery efficacy such as size, charge, structure, drug uptake, retention and its release profile alongside with cytocompatibility and safety were addressed. Moreover, the advantages and disadvantages of the different colloidal systems were emphasised.

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confidence: 72%

Polymer colloids as drug delivery systems for the treatment of arthritis

Saeedi

Alotaibi

Prokopovich

2020

Advances in Colloid and Interface Science

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“…Yin and colleagues developed thermo-responsive in situ-forming hydrogels via physical crosslinking with a rapid gelation time of 15 s initiated closer to body temperature. The drug-loaded hydrogels show the sustained release of NPs co-loaded with indomethacin (IND) and methotrexate (MTX) over 72 h for the treatment of rheumatoid arthritis [27]. In this instance, the gelation rate of physical crosslinking is influenced by polymer and drug compositions, as well as collective physiological responses.…”

Section: In Situ-forming Hydrogelsmentioning

confidence: 99%

Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update

Pushpamalar

Meganathan

Tan

et al. 2021

Gels

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Delivering a drug to the target site with minimal-to-no off-target cytotoxicity is the major determinant for the success of disease therapy. While the therapeutic efficacy and cytotoxicity of the drug play the main roles, the use of a suitable drug delivery system (DDS) is important to protect the drug along the administration route and release it at the desired target site. Polysaccharides have been extensively studied as a biomaterial for DDS development due to their high biocompatibility. More usefully, polysaccharides can be crosslinked with various molecules such as micro/nanoparticles and hydrogels to form a modified DDS. According to IUPAC, hydrogel is defined as the structure and processing of sols, gels, networks and inorganic–organic hybrids. This 3D network which often consists of a hydrophilic polymer can drastically improve the physical and chemical properties of DDS to increase the biodegradability and bioavailability of the carrier drugs. The advancement of nanotechnology also allows the construction of hydrogel DDS with enhanced functionalities such as stimuli-responsiveness, target specificity, sustained drug release, and therapeutic efficacy. This review provides a current update on the use of hydrogel DDS derived from polysaccharide-based materials in delivering various therapeutic molecules and drugs. We also highlighted the factors that affect the efficacy of these DDS and the current challenges of developing them for clinical use.

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“…Relieving swelling, reducing inflammation, and reversing the damage of articular cartilage can be achieved at the same time by injecting the hybrid hydrogel platform into the diseased joint [126]. Yin et al [127] designed a nanoparticle hybrid hydrogel platform for the synergistic treatment of RA. In this study, the hybrid system was made of temperature-sensitive hydrogel (D-NGel) and nanoparticles (D-NPs), which were loaded with indomethacin (IND) and MTX-specifically, the long-acting hydrogel formed after intra-articular injection.…”

Section: Micro-/nanoparticle Hybrid Hydrogel Platform In Symptomatic Treatmentmentioning

confidence: 99%

Effect of Micro-/Nanoparticle Hybrid Hydrogel Platform on the Treatment of Articular Cartilage-Related Diseases

Shan

et al. 2021

Gels

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Joint diseases that mainly lead to articular cartilage injury with prolonged severe pain as well as dysfunction have remained unexplained for many years. One of the main reasons is that damaged articular cartilage is unable to repair and regenerate by itself. Furthermore, current therapy, including drug therapy and operative treatment, cannot solve the problem. Fortunately, the micro-/nanoparticle hybrid hydrogel platform provides a new strategy for the treatment of articular cartilage-related diseases, owing to its outstanding biocompatibility, high loading capability, and controlled release effect. The hybrid platform is effective for controlling symptoms of pain, inflammation and dysfunction, and cartilage repair and regeneration. In this review, we attempt to summarize recent studies on the latest development of micro-/nanoparticle hybrid hydrogel for the treatment of articular cartilage-related diseases. Furthermore, some prospects are proposed, aiming to improve the properties of the micro-/nanoparticle hybrid hydrogel platform so as to offer useful new ideas for the effective and accurate treatment of articular cartilage-related diseases.

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Intra-articular injection of indomethacin–methotrexate in situ hydrogel for the synergistic treatment of rheumatoid arthritis

Abstract: Intra-articular injection of a temperature-sensitive hydrogel containing D-NPs formed by PEI-SS and IND and MTX.

Cited by 51 publications

References 27 publications

Polymer colloids as drug delivery systems for the treatment of arthritis

Polymer colloids as drug delivery systems for the treatment of arthritis

Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update

Effect of Micro-/Nanoparticle Hybrid Hydrogel Platform on the Treatment of Articular Cartilage-Related Diseases

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