2013
DOI: 10.1007/s00167-013-2438-7
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Intra-articular hylastan versus steroid for knee osteoarthritis

Abstract: Both IA hylastan injection regimens were effective in relieving pain with an acceptable safety profile. IA hylastan did not show a difference versus IA corticosteroid; therefore, the hypothesis of superior pain relief was not met. Further research is needed to compare the efficacy and safety of hylastan with other viscosupplements.

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Cited by 38 publications
(30 citation statements)
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“…Sodium hyaluronate injection is widely used in orthopedic treatment, especially in the knee joint (21,22). The results of arthrocentesis with additional injections (such as corticosteroids, visco-supplementation, or platelet-rich plasma) have varied greatly in patients with TMJ disorders, and no consensus has been reached regarding the most effective treatment (4,(23)(24)(25).…”
Section: Discussionmentioning
confidence: 99%
“…Sodium hyaluronate injection is widely used in orthopedic treatment, especially in the knee joint (21,22). The results of arthrocentesis with additional injections (such as corticosteroids, visco-supplementation, or platelet-rich plasma) have varied greatly in patients with TMJ disorders, and no consensus has been reached regarding the most effective treatment (4,(23)(24)(25).…”
Section: Discussionmentioning
confidence: 99%
“…The most common side effect was arthralgia, swelling and stiffness that occurred in equivalent percentages in each treatment and control group. One study had a significant difference23 in arthralgia of 17% in HA and 3.2% in IAS with resolution symptoms within 2–3 weeks. The other studies did not demonstrate a difference between HA and control in treatment-related adverse events (table 4).…”
Section: Resultsmentioning
confidence: 98%
“…Prior to surgery, knee arthritis symptoms can be ameliorated via methods such as exercise, physical therapy, ambulatory assist devices, NSAIDs, and intra-articular injections [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Exercise therapy was found to improve pain levels by 34%, while the new AAOS guidelines for treatment of knee OA no longer supports intra-articular hyaluronic acid injections, as they believe the studies supporting hyaluronic acid to be publication-biased, and that the results were not clinically significant [6,22,25,26].…”
Section: Discussionmentioning
confidence: 99%
“…A currently widely used method of alleviating knee pain nonsurgically is through intra-articular injections, including corticosteroids and hyaluronic acid [19][20][21][22][23][24][25][26][27][28]. Corticosteroids have significant pain reducing effects on patients; however, there have not been any identified predictors of response to intra-articular corticosteroid injections [19,20]. In a study by Habib et al, a hiccup reflex occurring following an intra-articular corticosteroid injection was reported, and the authors recommended avoiding corticosteroid injections if this phenomenon is known to happen in a patient [21].…”
Section: Non-surgical Treatment For Knee Arthritismentioning
confidence: 99%