Intra-articular drug delivery systems: overcoming the shortcomings of joint disease therapy

Burt, Helen M.; Tsallas, Antonia; Gilchrist, Seth; Liang, Linda S.

doi:10.1517/17425240802647259

Cited by 60 publications

(34 citation statements)

References 55 publications

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“…Current OA treatments are usually targeted to provide a symptomatic relief of pain and may only have restricted effects on joint degeneration. 17 Platelet gel has been used over the past 10 years in an increasing number of fields, particularly in novel orthopedic treatments. 18,19 Platelet gel is formed through the combination of PRP, thrombin, and calcium chloride.…”

Section: Discussionmentioning

confidence: 99%

Analyzing the Effects of Platelet Gel on Knee Osteoarthritis in the Rat Model

Güner

Buyukbebeci

2012

Clin Appl Thromb Hemost

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Platelet gel (PG) includes concentrated dose of growth factors which plays role in physiological processes of healing. The goal of this study is to evaluate repairing effects of intra-articular injection of PG use in a rat model of knee osteoarthritis (OA). A total of 20 rats were randomly distributed into a PG group and a control group. Both the groups were induced OA in knee joints with intra-articular formaline injection. The rats in the PG group and the control group were injected in the knee joint with PG and 0.9% NaCl solution, respectively. Two weeks after last injections, all rats were sacrificed by ether asphyxiation. Tissue samples were obtained from the knee joints and were examined histopathologically. No statistically significant differences were found between the groups regarding cartilage healing (P > .05). We were unable to determine any beneficial or harmful effects of PG on joint cartilage healing in OA.

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Section: Discussionmentioning

confidence: 99%

Analyzing the Effects of Platelet Gel on Knee Osteoarthritis in the Rat Model

Güner

Buyukbebeci

2012

Clin Appl Thromb Hemost

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“…And the residence of encapsulated drugs within the knee joint was greatly prolonged. For example, liposomal iohexol declined biexponentially with a terminal elimination half-life of 134 hours compared with free iohexol which was undetectable 3 hours after injection [20,22]. Liposomes are good candidates although a liposomal corticosteroid formulation containing dexamethasone-21-palmitate (Lipotalon) available in Germany is the only intra-articular liposomal product used in human patients [20].…”

Section: Liposomesmentioning

confidence: 99%

Micro- and Nano-Carrier Mediated Intra-Articular Drug Delivery Systems for the Treatment of Osteoarthritis

Zhang

Huang

2012

Journal of Nanotechnology

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The objective of this paper is to provide readers with current developments of intra-articular drug delivery systems. In recent years, although the search for a clinically successful ideal carrier is ongoing, sustained-release systems, such as polymeric micro-and nanoparticles, liposomes, and hydrogels, are being extensively studied for intra-articular drug delivery purposes. The advantages associated with long-acting preparations include a longer effect of the drug in the action site and a reduced risk of infection due to numerous injections consequently. This paper discusses the recent developments in the field of intra-articular sustained-release delivery systems for the treatment of osteoarthritis.

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“…This highlights the need for IA drug delivery preparations providing sustained release of the drug from a depot over a period of several weeks or months. Therefore, the prolonged action preparations for IA were investigated in the past few years (Thakkar et al, 2004;Betre et al, 2006;Burt et al, 2009). IA of paclitaxel and the parathyroid hormone loaded in PLGA microspheres (MPs) as a controlled release system has been reported to be successful in *Zhipeng Chen and Dan Liu contributed equally to the project and are considered co-first authors.…”

Section: Introductionmentioning

confidence: 99%

Development of nanoparticles-in-microparticles system for improved local retention after intra-articular injection

et al. 2013

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To increase the intra-articular (IA) retention time of osteoarthritis drugs in the synovial cavity and slow down the burst release of microspheres (MPs), we prepared a novel drug delivery system named nanoparticles-in-microspheres (NiMs). The system was constructed by dispersing the brucine-loaded nanoparticle, which was prepared by an emulsification method in the MPs. The NiMs were characterized by scanning electron microscope, Fourier transform infrared spectra and differential scanning calorimetry. After investigating the biocompatibility with synovium of NiMs in rats, the pharmacokinetics was studied and FX-imaging was used to visualize the transmission of nanoparticles after IA administration in rats. From the results, we know that the NiMs were spherical, there was no chemical bond between the drug and the polymer, and the drug was dispersed in the polymer in an amorphous form. Compared with MPs (41%), the burst release of NiMs could be slowed down to 9%. After that, the drug was released from NiMs by diffusion. The results of FX imaging in rats showed that the NiMs could stay in the articular cavity for over 11 d. The studies of pharmacokinetics revealed that the NiMs could slow down the burst release and improve retention in vivo. This study demonstrates the feasibility of using NiMs to slow down the burst release and increase the retention of therapeutic agents in articular joints.

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Intra-articular drug delivery systems: overcoming the shortcomings of joint disease therapy

Cited by 60 publications

References 55 publications

Analyzing the Effects of Platelet Gel on Knee Osteoarthritis in the Rat Model

Analyzing the Effects of Platelet Gel on Knee Osteoarthritis in the Rat Model

Micro- and Nano-Carrier Mediated Intra-Articular Drug Delivery Systems for the Treatment of Osteoarthritis

Development of nanoparticles-in-microparticles system for improved local retention after intra-articular injection

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