Intra- and Interdevice Deviation of Optical Coherence Tomography Angiography

Trachsler, Stefan; Baston, Arthur; Menke, Marcel N.

doi:10.1055/a-0747-5333

Cited by 10 publications

(9 citation statements)

References 23 publications

(15 reference statements)

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“…Here, vessel measures may vary greatly and cannot be transferred interchangeably between OCT-A devices. 21 In the present study, we did not see any clear longitudinal alteration of the DVC in eyes with or without past ON, suggesting that deep retinal vessels might be rather not affected during and after ON.…”

Section: Discussioncontrasting

confidence: 60%

Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis

Aly

Noll

Wicklein

et al. 2022

Neurol Neuroimmunol Neuroinflamm

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Background and ObjectivesRarefication of the retinal vasculature as measured by optical coherence tomography angiography (OCT-A) is a novel finding in patients with multiple sclerosis (MS). This study aimed to analyze longitudinal dynamics of the retinal vasculature following an acute inflammatory relapse including acute optic neuritis (ON) and to search for associations with alterations of the retinal architecture and visual function.MethodsThis prospective longitudinal cohort study included patients with relapsing-remitting MS or clinically isolated syndrome having an acute ON (n = 20) or a non-ON relapse (n = 33). Patients underwent examinations at baseline and after 7, 14, 28, 90, and 180 days with OCT, OCT-A, and assessment of the high- (HCVA) and low-contrast visual acuity (LCVA).ResultsRetinal vessel loss of the superficial vascular complex (SVC) evolves early after ON and reaches a plateau between 90 and 180 days (relative vessel loss 15% ± 8% [mean ± SD]). In addition, an 18% ± 18% intraindividual increase of the foveal avascular zone (FAZ) is evident within 180 days after acute ON. Both SVC thinning and FAZ enlargement were associated with worse HCVA and LCVA. Rarefication of the SVC evolved simultaneously to thinning of the common ganglion cell and inner plexiform layer (GCIP) after ON. No alterations of the deep vascular complex were seen in eyes with ON, and no alterations of the retinal vasculature were recognized in patients having acute non-ON relapses.DiscussionRarefication of the SVC and growing of the FAZ evolve rapidly after ON and are linked to persistent visual disability. ON-related SVC thinning might be closely linked to GCIP atrophy and might occur due to an altered local metabolic activity within inner retinal layers.

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Section: Discussioncontrasting

confidence: 60%

Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis

Aly

Noll

Wicklein

et al. 2022

Neurol Neuroimmunol Neuroinflamm

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“…This small and opposing effect of scaling is due to the average axial length of our cohort being slightly greater than the assumed axial length of the AngioVue device but slightly less than the assumed axial length of the AngioPlex device. Taken together, our findings suggest that previously reported differences in FAZ area between different OCT-A devices 15,16,18,19,22,23,52 are most likely due to different postprocessing methods inherent to the devices as opposed to fundamental differences in the images themselves. Additionally, it is possible that the axial length characteristics of the subjects in earlier studies differed relative to the device(s) used, which would affect the reported relative differences in FAZ area between devices.…”

Section: Discussionsupporting

confidence: 59%

“…Previous studies have shown that errors in image scale 27 , 51 and differing segmentation methods 19 , 38 can affect measurements of FAZ area. 15 , 16 , 18 , 19 , 22 , 23 , 52 Strengths of our study are that: (1) we used manual segmentation of the FAZ contour and (2) we used the subject's axial length and knowledge of the assumed axial for each device to derive the image scale for each OCT-A image. This approach allowed us to isolate the impact of the OCT-A device on FAZ metrics.…”

Section: Discussionmentioning

confidence: 99%

“…Following the model of studies examining structural OCT measurements, such as retinal thickness, 12,13 there have been dozens of studies looking at the impact of device model/manufacturer on a number of OCT-A vasculature metrics. These studies have examined clinical performance, 14,15 FAZ area, [16][17][18][19][20][21][22][23] and vessel density. [18][19][20][24][25][26] With only a couple of exceptions, the general consensus of these studies is that agreement of quantitative metrics between devices is poor.…”

Section: Introductionmentioning

confidence: 99%

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Assessing the Influence of OCT-A Device and Scan Size on Retinal Vascular Metrics

Kraker

Omoba

Cava

et al. 2020

Trans. Vis. Sci. Tech.

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The purpose of this study was to investigate the effect of device and scan size on quantitative optical coherence tomography angiography (OCT-A) metrics. Methods: The 3 × 3 mm scans from Optovue AngioVue and Zeiss AngioPlex systems were included for 18 eyes of 18 subjects without ocular pathology. The foveal avascular zone (FAZ) was segmented manually by two observers, from which estimates of FAZ area (using both the nominal image scale and the axial length corrected image scale) and acircularity were derived. Three scan sizes (3 mm, 6 mm HD, and 8 mm) from the AngioVue system were included for 15 eyes of 15 subjects without ocular pathology. For each subject, larger image sizes were resized to the same resolution as 3 × 3 mm scans, aligned, then cropped to a common area. FAZ area, FAZ acircularity, average and total parafoveal intercapillary area, vessel density, and vessel end points were computed. Results: Between the devices used here, there were no significant differences in FAZ acircularity (P = 0.88) or FAZ area using scaled (P = 0.11) or unscaled images (P = 0.069). Although there was no significant difference in FAZ area across scan sizes (P = 0.30), vessel morphometry metrics were all significantly influenced by scan size. Conclusions: The scan devices and sizes used here do not affect FAZ area measures derived from manual segmentations. In contrast, vessel morphometry metrics are affected by scan size. As individual differences in axial length induce differences in absolute scan size, extreme care should be taken when interpreting metrics of vessel morphometry, both between and within OCT-A devices. Translational Relevance: A better characterization of the confounds surrounding OCT-A retinal vasculature metrics can lead to improved application of these metrics as biomarkers for retinal and systemic diseases.

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“…Besides, the appearance of OCTA image data strongly depends on details of the OCT device, scan protocols, signal processing, and algorithms used to generate OCTA information from structural OCT data. [36] Therefore, the results presented must not be directly transferred to other OCTA devices.…”

Section: Discussionmentioning

confidence: 99%

Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults

Nelis¹,

Schmitz²,

Klose³

et al. 2019

PLoS ONE

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Optical coherence tomography angiography (OCT-A) represents the most recent modality in retinal imaging for non-invasive and depth-selective visualization of blood flow in retinal vessels. With regard to quantitative OCTA measurements for early detection of subclinical alterations, it is of great interest, which intra- and extra-ocular factors affect the results of OCTA measurements. Here, we performed OCTA imaging of the central retina in 65 eyes of 65 young healthy female and male participants and evaluated individual physical fitness levels by standard lactate diagnostic using an incremental maximal performance running test. The main finding was that OCTA measurements of the foveal avascular zone (FAZ) area were associated with physical fitness. Using multivariate regression analysis, we found that running speed at the individual lactate threshold, a marker strongly associated with aerobic performance capacity, significantly contributed to differences in FAZ area (β = 0.111, p = 0.032). The data indicates that smaller FAZ areas are likely observed in individuals with higher aerobic exercise capacity. Our findings are also of interest with respect to the potential use of retinal OCTA imaging to detect exercise-induced microvascular adaptations in future studies.

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Intra- and Interdevice Deviation of Optical Coherence Tomography Angiography

Cited by 10 publications

References 23 publications

Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis

Dynamics of Retinal Vessel Loss After Acute Optic Neuritis in Patients With Relapsing Multiple Sclerosis

Assessing the Influence of OCT-A Device and Scan Size on Retinal Vascular Metrics

Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults

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