Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults

Nelis, Pieter; Schmitz, Boris; Klose, Andreas; Rolfes, Florian; Alnawaiseh, Maged; Krüger, Michael; Eter, Nicole; Brand, Stefan-Martin; Alten, Florian

doi:10.1371/journal.pone.0225769

Cited by 8 publications

(3 citation statements)

References 34 publications

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“…Accordingly, physical exercise in young adults has been shown to lead to a decrease in macular vessel density as seen on OCT-angiography (Hua et al, 2021;Mauget-Faysse et al, 2021;Vo Kim et al, 2019). Individuals exhibiting higher aerobic exercise capacity were shown to have smaller foveal avascular zones suggestive of exercise-driven adaptation in the retina (Nelis et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

The Assessment of Acute Chorioretinal Changes Due to Intensive Physical Exercise in Senior Elite Athletes

Szalai

Csorba

Tian

et al. 2023

Journal of Aging and Physical Activity

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Regular physical exercise is known to lower the incidence of age-related eye diseases. We aimed to assess the acute chorioretinal alterations in older adults following intense physical strain. Seventeen senior elite athletes were recruited who underwent an aerobic exercise on a cycle ergometer and macular scanning by optical coherence tomography. A significant thinning of the entire retina was observed 1 min after exercise, followed by a thickening at 5 min, after which the thickness returned to baseline. This trend was similar in almost every single retinal layer, although a significant change was observed only in the inner retina. Choroidal thickness changes were neither significant nor did they correlate with the thickness changes of intraretinal layers. The mechanism of how these immediate retinal changes chronically impact age-related sight-threatening pathologies that, in turn, result in a substantially reduced quality of life warrants further investigation on nontrained older adults as well.

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Section: Discussionmentioning

confidence: 99%

The Assessment of Acute Chorioretinal Changes Due to Intensive Physical Exercise in Senior Elite Athletes

Szalai

Csorba

Tian

et al. 2023

Journal of Aging and Physical Activity

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“…Not all factors known to influence OCTA measurements were recorded and considered. Blood pressure, heart rate, eye pressure and refraction were measured and found to be in acceptable ranges, other parameters as physical fitness and hematocrit were not assessed 53 , 54 .…”

Section: Discussionmentioning

confidence: 99%

Light conditions influence optic nerve OCT angiography parameter in healthy subjects with neutral pupils

Nelis,

Nieweler,

Brücher

et al. 2023

Sci Rep

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Optical coherence tomography angiography measurements are influenced by a range of environmental factors as blood pressure and physical fitness. The present study aimed to evaluate the effects of light and dark exposure in eyes with neutral and mydriatic pupils on vessel density in the macular and optic nerve head regions, as measured using optical coherence tomography angiography (OCTA). 55 eyes of 55 healthy volunteers (28 patients with neutral pupils; 27.18 ± 4.33 years) were examined using a high-speed and high-resolution spectral-domain OCT XR Avanti system with a split-spectrum amplitude de-correlation angiography algorithm. OCTA imaging was performed after dark adaptation and after exposure to light. The vessel density data of the superficial and deep retinal macular and optic nerve head region OCT-angiogram were analyzed for these two light conditions. Through Bonferroni correction for multiple testing, the p- value was adapted from 0.05 to 0.017. In eyes with neutral pupils, a significant increase was found in the capillary region of the optic nerve head region (p = 0.002), comparing dark- and light-adaptation. In the macular region of eyes with neutral (p = 0.718) and mydriatic pupils (p = 0.043), no significant differences were observed, as were any in the optic nerve head region of the mydriatic eyes (p = 0.797). This observation suggests that light conditions could be a possible factor influencing OCTA measurements. After dark exposure, vessel density data were significantly different between eyes with neutral and mydriatic pupils (nerve head region: p < 0.0001, superficial macula: p < 0.0001, deep macula: p = 0.0025). These data warn for the effect of mydriatic drops on vessel density measurements.

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“…Eine negative Korrelation zwischen körperlicher Fitness und FAZ-Größe wurde auch von Nelis et al. herausgestellt [ 55 ].…”

Section: Einfluss Von Risikofaktoren Für Kardiovaskuläre Erkrankungen Auf Die Oct-a-parameterunclassified

Die optische Kohärenztomographie-Angiographie und Erkrankungen des kardiovaskulären Spektrums. Ein Überblick über die aktuelle Studienlage

2021

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Zusammenfassung Hintergrund Kardiovaskuläre Erkrankungen (KVE) sind die Haupttodesursache weltweit. Die Beobachtbarkeit von Veränderungen der retinalen Gefäße im Zusammenhang mit KVE mittels Fundoskopie ist schon seit Langem bekannt. Ein neuartiges Verfahren zur nichtinvasiven und detaillierten Darstellung und Quantifizierung der retinalen und papillären Gefäße stellt die optische Kohärenztomographie-Angiographie (OCT-A) dar. Durch die OCT‑A ist es möglich, Gefäßveränderungen einfach und gut reproduzierbar zu visualisieren, weswegen ihr Einsatz nicht nur auf augenärztliche Fragestellungen beschränkt ist. In den vergangenen Jahren sind einige experimentelle und klinische Studien zur Darstellbarkeit und Quantifizierung von Gefäßveränderungen durch die OCT‑A bei Erkrankungen des kardiovaskulären Spektrums publiziert worden. In der vorliegenden Übersicht werden die wichtigsten Erkenntnisse aus diesen Studien zusammengefasst. Methoden Grundlage dieser Arbeit bilden eine umfassende selektive Literaturrecherche und die Darstellung eigener Daten. Ergebnisse Mittlerweile liegen zu vielen Erkrankungen des kardiovaskulären Spektrums OCT-A-Studien vor, die verdeutlichen, dass systemische Gefäßerkrankungen mit Veränderungen der retinalen Mikrozirkulation verbunden sind. Mit der OCT‑A können diese Veränderungen visualisiert und reproduzierbar quantifiziert werden. Oftmals ist es möglich, subklinische Veränderungen aufzuzeigen, bevor die zugrunde liegende Erkrankung anderweitig messbare Veränderungen oder für den Patienten merkbare Symptome verursacht. Schlussfolgerung Die OCT‑A ist eine vielversprechende Bildgebungsmethode auf dem Gebiet der KVE in Wissenschaft und klinischer Anwendung. Sie kann zur Diagnostik und Quantifizierung retinaler Gefäßveränderungen eingesetzt werden. Weitere Studien werden zeigen, ob die OCT‑A bei der Einschätzung des individuellen kardiovaskulären Risikoprofils helfen kann.

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Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults

Cited by 8 publications

References 34 publications

The Assessment of Acute Chorioretinal Changes Due to Intensive Physical Exercise in Senior Elite Athletes

The Assessment of Acute Chorioretinal Changes Due to Intensive Physical Exercise in Senior Elite Athletes

Light conditions influence optic nerve OCT angiography parameter in healthy subjects with neutral pupils

Die optische Kohärenztomographie-Angiographie und Erkrankungen des kardiovaskulären Spektrums. Ein Überblick über die aktuelle Studienlage

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