Die optische Kohärenztomographie-Angiographie und Erkrankungen des kardiovaskulären Spektrums. Ein Überblick über die aktuelle Studienlage

Leclaire, Martin Dominik; Eter, Nicole; Alnawaiseh, Maged

doi:10.1007/s00347-021-01336-1

Cited by 4 publications

(3 citation statements)

References 74 publications

(83 reference statements)

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“…OCT-A is increasingly being used. The unique possibility of rapid and non-invasive imaging of blood vessels and the implication of common diseases like cardiovascular disease, diabetes mellitus and autoimmune diseases on the VD makes OCT-A a promising new technology in diagnosing and monitoring these disorders [36,[41][42][43]. It is therefore important that potential confounding factors influencing OCT-A measurement results are known and thus can be considered in the interpretation of measurement results in both scientific applications and in daily clinical practice.…”

Section: Discussionmentioning

confidence: 99%

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Reduced Retinal Blood Vessel Densities Measured by Optical Coherence Tomography Angiography in Keratoconus Patients Are Negatively Correlated with Keratoconus Severity

Leclaire,

Storp,

Lahme

et al. 2024

Diagnostics

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Keratoconus (KC) is the most common corneal ectasia. Optical coherence tomography angiography (OCT-A) is a relatively new non-invasive imaging technique that allows the visualization and quantification of retinal and choriocapillary blood vessels. The aim of this study is to assess retinal and choriocapillary vessel density (VD) differences between KC patients and healthy controls and to investigate correlations between VD and KC severity. Fifty-two eyes were included in this exploratory study: twenty-six eyes from 26 KC patients and twenty-six eyes from 26 age- and gender-matched healthy controls. All patients underwent Scheimpflug corneal topography with Pentacam, axis lengths measurement and optical coherence tomography angiography (OCT-A). The thinnest spot in corneal pachymetry, maximum K (Kmax) and KC severity indices from the Belin/Ambrósio enhanced ectasia display (BAD) were also assessed. There was a distinct reduction particularly in the retinal VD of the superficial capillary plexus (SCP). Correlation analyses showed strong and moderate negative correlations between the VD in the macular SCP and BAD KC scores and between the SCP VD and Kmax. There was no difference in retinal thickness between the KC and healthy controls. With this study, further evidence for altered VD measurements by OCT-A in KC patients is given. For the first time, we demonstrated negative correlations between BAD KC scores and retinal blood vessel alterations. A major limitation of the study is the relatively small sample size. Since an artefactual reduction of the quantitative OCT-A measurements due to irregular corneal topography in KC must be assumed, it remains to be investigated whether there are also actual changes in the retinal microcirculation in KC.

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Section: Discussionmentioning

confidence: 99%

“…Numerous factors that influence the quantitative measurement parameters of OCT-A, such as axial length, the presence of cardiovascular disease and diabetes mellitus and the presence of cilioretinal vessels and age, have been described [30,[34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Reduced Retinal Blood Vessel Densities Measured by Optical Coherence Tomography Angiography in Keratoconus Patients Are Negatively Correlated with Keratoconus Severity

Leclaire,

Storp,

Lahme

et al. 2024

Diagnostics

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“…CADASIL is a rare autosomal dominant disease. It is the most common cause of hereditary ischemic strokes [ 2 , 78 ]. Due to a mutation of the Notch-3 gene, the vessel wall of the brain vasculature thickens and lumen stenosis occurs [ 2 ].…”

Section: Oct-a Findings In Neurological Diseasesmentioning

confidence: 99%

The Value of Optical Coherence Tomography Angiography (OCT-A) in Neurological Diseases

Augustin

Atorf

2022

Diagnostics

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Optical coherence tomography angiography (OCT-A) was commercially introduced in 2014. OCT-A allows a fast, non-invasive, three-dimensional analysis of the retinal vasculature from the vitreoretinal interface to the choriocapillaris. The results can be evaluated separately in automated or custom-defined retinal layers. Since its introduction, OCT-A has also been used in patients with neurological diseases in order to find and characterize retinal biomarkers. Many neurological diseases have retinal manifestations, often preceding the key symptoms of the neurological disease. Anatomically and developmentally, the retina is a part of the brain. In contrast to the brain, the retina is easily accessible for imaging methods; moreover, retinal imaging is more cost-effective than brain imaging. In this review, the current knowledge about OCT-A findings and possible OCT-A biomarkers in neurological diseases is summarized and discussed regarding the value of OCT-A as a diagnostic tool in neurological diseases.

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The ganglion cell complex damage in coronary artery disease

Ural Fatihoglu,

Fatihoglu

2023

Photodiagnosis and Photodynamic Therapy

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Die optische Kohärenztomographie-Angiographie und Erkrankungen des kardiovaskulären Spektrums. Ein Überblick über die aktuelle Studienlage

Cited by 4 publications

References 74 publications

Reduced Retinal Blood Vessel Densities Measured by Optical Coherence Tomography Angiography in Keratoconus Patients Are Negatively Correlated with Keratoconus Severity

Reduced Retinal Blood Vessel Densities Measured by Optical Coherence Tomography Angiography in Keratoconus Patients Are Negatively Correlated with Keratoconus Severity

The Value of Optical Coherence Tomography Angiography (OCT-A) in Neurological Diseases

The ganglion cell complex damage in coronary artery disease

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