Intra-accumbens baclofen, but not muscimol, mimics the effects of food withdrawal on feeding behaviour

Pulman, Kim G.T.; Somerville, Elizabeth M.; Clifton, Peter G.

doi:10.1016/j.pbb.2010.05.028

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…Baldo et al [33] reported elevated c- fos expression in the arcuate after bilateral infusion of a substantially higher dose of muscimol than was used here. The ipsilateral activation of LH, PVN and arcuate by baclofen is consistent with an interpretation of the induced feeding behavior being similar to normal, homeostatic, feeding [17].There was an increase in c- fos activation ipsilaterally in CeA after baclofen infusion (Figure 8, Table 3). There is a projection of LH to CeA [38]–[40] and there is also evidence for a direct projection from the accumbens shell to CeA [30].…”

Section: Discussionsupporting

confidence: 85%

“…The response rate of animals infused with vehicle decreases after 15 minutes which might indicate the development of satiety. However the actual amount of of food ingested by this point is relatively small, and is unlikely to exceed 0.7 g, which is less than half the amount of increase in free intake at this dose in an earlier study [17].…”

Section: Discussionmentioning

confidence: 65%

“…However we have shown that the effects of intra-accumbens infusions of either the GABA A receptor agonist muscimol or the GABA B receptor agonist baclofen on feeding-related behaviours can be distinguished [17]. The data suggested that the action of baclofen mimics more ‘natural’ motivational manipulations such as a short period of food withdrawal.…”

Section: Introductionmentioning

confidence: 87%

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Intra-Accumbens Baclofen, But Not Muscimol, Increases Second Order Instrumental Responding for Food Reward in Rats

2012

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Stimulation of either GABAA or GABAB receptors within the nucleus accumbens shell strongly enhances food intake in rats. However the effects of subtype-selective stimulation of GABA receptors on instrumental responses for food reward are less well characterized. Here we contrast the effects of the GABAA receptor agonist muscimol and GABAB receptor agonist baclofen on instrumental responding for food using a second order reinforcement schedule. Bilateral intra-accumbens administration of baclofen (220–440 pmol) stimulated responding but a higher dose (660 pmol) induced stereotyped oral behaviour that interfered with responding. Baclofen (220–660 pmol) also stimulated intake of freely available chow. Muscimol (220–660 pmol) was without effect on responding for food on this schedule but did stimulate intake of freely available chow. Unilateral administration of either baclofen or muscimol (220 pmol) induced similar patterns of c-fos immunoreactivity in several hypothalamic sites but differed in its induction in the central nucleus of the amygdala. We conclude that stimulation of GABAA or GABAB receptors in the nucleus accumbens shell of rats produces clearly distinguishable effects on operant responding for food.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 87%

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Intra-Accumbens Baclofen, But Not Muscimol, Increases Second Order Instrumental Responding for Food Reward in Rats

2012

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“…In the case of sugar intake, local microinjections of GABA into the ventral tegmental area block the reward response to sucrose in rats [69]. Infusion of baclofen, a GABA-B receptor agonist, in the nucleus accumbens shell results in an increase in non-palatable food intake, suggesting enhanced motivation, while infusion of muscimol, a GABA-A receptor agonist, in the same region also increases feeding, but seems to have more of an effect on the motoric aspects of feeding [70].…”

Section: Gamma-aminobutyric Acid Gaba and Binge Eating: Laboratory Anmentioning

confidence: 99%

Pharmacological Interventions for Binge Eating: Lessons from Animal Models, Current Treatments, and Future Directions

Berner

Bocarsly²,

Hoebel³

et al. 2011

CPD

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Binge eating behavior has been noted in some eating disorders as well as in obesity. The goal of this paper is to review current, non-serotonergic pharmaceutical approaches to treat binge eating. Further, using information derived from preclinical models, we discuss candidate neurotransmitter systems for study as targets for the treatment of binge eating. Dopaminergic circuits have been implicated in both laboratory animal models and human studies of binge eating, though existing medications specifically targeting the dopaminergic system have been found to have adverse side effects. Opioidergic and gamma-aminobutyric acid (GABA) systems also appear to be highly involved in aspects of binge eating; further, opioid antagonists, such as naloxone and naltrexone, and GABA agonists, such as baclofen, have all been shown to be effective in treating alcohol dependence and may be equally efficacious in attenuating binge eating. Preclinical evidence, and some clinical evidence, suggests that cannabinoid antagonism may also be useful in the treatment of binge eating, although the specific effect of antagonists, on binge consumption remains unclear. Overall, each of these neurotransmitter systems provides a promising avenue for new pharmacotherapy development for binge eating, and preclinical and human studies provide a strong rationale for the development of highly-selective drugs that target this neurocircuitry.

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Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABAB and cannabinoid CB1 receptors

et al. 2017

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Intra-accumbens baclofen, but not muscimol, mimics the effects of food withdrawal on feeding behaviour

Cited by 6 publications

References 21 publications

Intra-Accumbens Baclofen, But Not Muscimol, Increases Second Order Instrumental Responding for Food Reward in Rats

Intra-Accumbens Baclofen, But Not Muscimol, Increases Second Order Instrumental Responding for Food Reward in Rats

Pharmacological Interventions for Binge Eating: Lessons from Animal Models, Current Treatments, and Future Directions

Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABAB and cannabinoid CB1 receptors

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