Intra-Abdominal Use of Taurolidine or Heparin as Alternative Products to an Antiadhesive Barrier (Seprafilm®) in Adhesion Prevention: An Experimental Study on Mice

Bahadir, Isamettin; Öncel, Mustafa; Kement, Metin; Sahip, Yusuf

doi:10.1007/s10350-007-9074-6

Cited by 29 publications

(20 citation statements)

References 24 publications

(25 reference statements)

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“…In literature, there is a study in which in 2 ml (0.04 g) of taurolidine 2% solution has been used as an adhesion preventative. [30] Results of that study were similar to our findings. They were not able to discover any dose-dependent effects.…”

Section: Discussionsupporting

confidence: 91%

Separately and synergistic effects of taurolidine and icodextrin in preventing intraabdominal adhesions

Kurt¹,

Sıkar

Kaptanoğlu³

et al. 2017

Ulus Travma Acil Cerrahi Derg

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Section: Discussionsupporting

confidence: 91%

Separately and synergistic effects of taurolidine and icodextrin in preventing intraabdominal adhesions

Kurt¹,

Sıkar

Kaptanoğlu³

et al. 2017

Ulus Travma Acil Cerrahi Derg

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“…Peritoneal adhesion preventing property of TRD is contradictory to the requirement of ideal pleurodesis agent. 16,22) We hypothesized that a chemical irritation effect might be responsible for air leak cessation in TRD instillation, because the procedure induced regional irritation symptoms (chest pain) in most patients and some degree of systemic symptoms (mild fever). In animal experiments, visceral pleural thickening was more prominent in the TRD group than in the control group.…”

Section: Discussionmentioning

confidence: 99%

Taurolidine: A New Alternative Agent for the Management of the Postoperative Air Leak

Byun

Park

Shim

et al. 2013

ATCS

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Purpose: To evaluate the efficacy of taurolidine instillation on postoperative air leak by clinical study and to investigate the mechanism of action by animal experiments. Methods: Outcomes of taurolidine instillation in patients with postoperative air leak were retrospectively reviewed. 100 ml of 1% taurolidine solution was instilled through a chest tube in patients with postoperative air leak lasting 4days or more. Success was defined as cessation of air leak within 24 hours with full expansion of lung on chest radiograph and subsequent removal of chest tube within another 24 hours. The effect of taurolidine instillation was estimated by development of adhesion and thickening of the visceral pleura in rabbits. The study group was compared with a control group and a talc poudrage group. Results: Out of 75 patients, the success rate was 66.7%. Out of 96 total attempts, taurolidine instillation was successful in 55%. In animal experiments, pleural adhesion was minimal in the taurolidine and control groups, whereas the talc group showed more adhesions. The taurolidine group showed a moderate visceral pleural thickening. The talc group showed severe visceral pleural thickening, whereas the control group showed mild thickening. Conclusion: Taurolidine is an effective alternative agent for the management of air leak. A chemical sclerosing effect is suggested as the mechanism of air leak cessation Keywords: taurolidine, instillation, air leak thus increases pain, risk of infection, and cost of care.

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“…(131,248) In the same vein, dipyramidole, a phosphodiestarase inhibitor, has also been found to be of value. Non-viral transfection of Smad7 significantly decreased the incidence and severity of peritoneal adhesions in rats, but the use of gene therapy as a preventive agent against adhesions requires much more work prior to any clinical trial.…”

Section: Coagulation/fibrinolysis/matrix Depositionmentioning

confidence: 94%

Intra-abdominal adhesions: Anatomy, physiology, pathophysiology, and treatment

Beyene¹,

Kavalukas²,

Barbul³

2015

Current Problems in Surgery

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Intra-Abdominal Use of Taurolidine or Heparin as Alternative Products to an Antiadhesive Barrier (Seprafilm®) in Adhesion Prevention: An Experimental Study on Mice

Abstract: All products are effective in adhesion prevention. Heparin use provides the best results but may be associated with a higher mortality rate related to intra-abdominal bleeding. Taurolidine may be an alternative product to Seprafilm , but further studies are required.

Cited by 29 publications

References 24 publications

Separately and synergistic effects of taurolidine and icodextrin in preventing intraabdominal adhesions

Separately and synergistic effects of taurolidine and icodextrin in preventing intraabdominal adhesions

Taurolidine: A New Alternative Agent for the Management of the Postoperative Air Leak

Intra-abdominal adhesions: Anatomy, physiology, pathophysiology, and treatment

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