Intra-abdominal primary monophasic synovial sarcoma with hemangiopericytoma-like areas

Rao, Lakshmi; Jaiprakash, Padmapriya; Palankar, Nagaraj; Gowda, Vinay N

doi:10.4103/0973-1482.110393

Cited by 3 publications

(3 citation statements)

References 4 publications

(9 reference statements)

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“…CD34, CD117, h-caldesmon, and SMA are negative markers. Focal and weak positivity of DOG1, such in our case can be misleading, particularly in intraabdominal SS [ 6 , 7 ]. TLE1 and SS18–SSX [ 14 ] are constant positive markers and are considered a good tool for SS diagnosis, and they can replace the use of FISH for identification of SYT gene break apart.…”

Section: Discussionmentioning

confidence: 99%

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A case of primary mesenteric synovial sarcoma: a challenging presentation

Abdessayed,

Barka,

Mabrouk

et al. 2023

surg case rep

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Background Synovial sarcoma is an uncommon soft tissue malignancy that mainly occurs near tendon sheath and bone joints. Primary intra-abdominal location is exceedingly rare and characterized by non-specific clinical signs. Case presentation We report the case of a young female without medical history who presented with acute abdominopelvic pain. Ultrasound echography revealed a right mass measuring 7 cm in greater diameter cystic with solid areas, likely of ovarian origin. A coelioscopy with peritoneal biopsies was performed. Histological examination with immunohistochemistry concluded the diagnosis of GIST. The patient was referred to the surgery department and after laboratory routine analysis and computed tomography, the patient was proposed to surgical management. Per-operative findings revealed a mesenteric mass locally invading the greater omentum and the appendicular wall. Pathological examination with immunochemistry confirmed the diagnosis of mesenteric monophasic synovial sarcoma invading the appendicular wall with positive surgical margins. Chemotherapy was proposed with a good response. Our patient is free from disease 9 months later. Conclusions We aimed through this case report to discuss mesenteric presentation monophasic SS, mimicking ovarian malignancy, emphasizing clinicopathological features and differential diagnoses.

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Section: Discussionmentioning

confidence: 99%

“…It occurs at any age, but it is more common in adolescents and young adults aged between 15 and 35 years [ 2 , 4 ]. SS has been reported in any part of the body [ 6 ]. Classically, it rises in the deep soft tissue near the tendon sheath or joints [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

A case of primary mesenteric synovial sarcoma: a challenging presentation

Abdessayed,

Barka,

Mabrouk

et al. 2023

surg case rep

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“…The biphasic SS harbors both spindle and epithelial cell components in varying proportions, and SS sometimes poses a diagnostic challenge especially if it arises in a rare location. Although its origin is still uncertain, it has been reported to occur in a variety of body sites including intra-abdomenal and pelvis (2)(3)(4)(5)(6). Because of the limited number of cases reported the prognosis of SS in the pelvis is still poorly understood.…”

mentioning

confidence: 99%

Two Cases of Biphasic Synovial Sarcoma With Expression of PAX8 and ER: A Diagnostic Pitfall

Wang

Chen

et al. 2022

International Journal of Gynecological Pathology

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Synovial sarcoma (SS) is a high-grade malignant neoplasm frequently arising in the deep soft tissue of the lower and upper extremities of young adults. Primary SS in the pelvis is extremely rare with scattered case reports. It often causes a diagnostic challenge in small biopsy and/or with aberrant expression of immunohistochemical markers. Here, we report 2 unusual cases of SS in the pelvis. Microscopically both cases present with biphasic morphology including spindle and epithelioid cells. In addition, the tumor cells in both cases expressed PAX8 and estrogen receptor. PAX8 is a transcription factor usually expressed in tumors of thyroid gland, kidney, and Müllerian system origin. The expression of PAX8 especially with co-expression of estrogen receptor can be misleading and result in a diagnosis of Müllerian tumors in female patients with pelvic masses. The diagnosis of SS for both cases was confirmed either with the fluorescence in situ hybridization or reverse transcription polymerase chain reaction showing a SS18 (SYT) (18q11) gene rearrangement. It is imperative to include SS in the differential diagnosis for malignant neoplasms exhibiting monotonous spindle cells (monophasic SS) and biphasic mixed monotonous spindle and epithelioid tumor cells in female patients with a pelvic mass. Molecular study for SS18 translocation is essential for the diagnosis in such cases.

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Synovial-Like Neoplasms (Synovial Sarcoma) of the Liver

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Intra-abdominal primary monophasic synovial sarcoma with hemangiopericytoma-like areas

Cited by 3 publications

References 4 publications

A case of primary mesenteric synovial sarcoma: a challenging presentation

A case of primary mesenteric synovial sarcoma: a challenging presentation

Two Cases of Biphasic Synovial Sarcoma With Expression of PAX8 and ER: A Diagnostic Pitfall

Synovial-Like Neoplasms (Synovial Sarcoma) of the Liver

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